Resource Support Core

资源支持核心

• 批准号: 10540793
• 负责人: VITALY NAPADOW
• 金额: $ 9.8万
• 依托单位: MASSACHUSETTS GENERAL HOSPITAL
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-02-01 至 2024-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10540793
• 关键词: 3-Dimensional; Address; Anatomy; Animal Experiments; Animal Model; Animals; Area; Behavioral; Biometry; Blood Vessels; Brain; Brain region; Clinical; Collection; Communities; Consultations; Data; Data Analyses; Data Pooling; Data Set; Databases; Development; Distributed Databases; Ensure; Etiology; Evaluation; Faculty; Fetal Development; Functional Imaging; Functional Magnetic Resonance Imaging; Funding; Glean; Heart; Human; Human Resources; Image; Image Analysis; Immune; Individual; Infrastructure; Institution; Intervention; Investigation; Magnetic Resonance Imaging; Major Depressive Disorder; Measurement; Methods; Mission; Modeling; Moods; Nature; Neuroanatomy; Neurobiology; Neurosciences; Noise; Outcome; Pathway interactions; Peripheral; Physiologic pulse; Physiological; Physiology; Rattus; Reproducibility; Research; Research Personnel; Resolution; Resource Sharing; Resources; Rest; Sex Differences; Signal Transduction; Source; Standardization; Stimulus; Stress; System; Techniques; Testing; Therapeutic Intervention; Time; Transdermal substance administration; Translating; United States National Institutes of Health; Vagus nerve structure; Work; analytical tool; attenuation; biological adaptation to stress; biomedical imaging; computerized data processing; data acquisition; data sharing; data structure; database structure; design; experimental study; heart rate variability; human model; interest; mathematical model; middle age; neural; neuroimaging; neuroinformatics; neuroregulation; novel; prenatal stress; respiratory; response; sex; sharing platform; signal processing; synergism; tool; vagus nerve stimulation; web portal

PROJECT SUMMARY The Resource Support Core (RSC) will provide infrastructure and tools to enable a cohesive approach to the collection, analysis, storage and sharing of data across the SCORE projects. The RSC will also provide expert support in areas such as biostatistics, transcutaneous vagus nerve stimulation, and advance autonomic and neuroimaging analyses. Establishing a unified approach enhances the quality of all studies, allowing each project to inform the others in potentially significant ways, and enabling valuable exploratory analyses through the pooling of data collected by multiple projects. The noninvasive nature of MRI allows for multiple experiments on an individual subject, either during the course of one examination period or on multiple occasions, as proposed in the current proposal to accomplish the aims of projects 1 and 2. The imaging data must be registered accurately, in both space and time, and interpreted to isolate physiological phenomena of interest from extraneous noise sources. Three-dimensional, high-resolution, anatomical MRI images will provide the basis for interrelating neuroimaging information. A broad range of functional imaging analytic tools will then be applied to interrogate both resting brain state and task- and/or stimulus-induced regional activation. The image analysis tools we propose have been extensively tested and validated by investigators at the Athinoula A. Martinos Center for Biomedical Imaging, over many years. The RSC will provide access to this broad neuroimaging expertise of the Martinos Center and will deliver a reproducible and efficient means to obtain, analyze, test and correlate structural and functional neuroimaging with physiological data. The RSC will also provide support on biomedical signal processing by developing and executing plans for advanced mathematical modeling and processing of physiological measurements taken in both the animal and human experiments. This will facilitate translational analyses of the mechanisms of autonomic dysregulation explored in projects 1 and 3. Experts on the implementation of non-invasive vagus nerve stimulation techniques in human and animal models have been included in the RSC and will assist in the experimental set up and interpretation of vagal neuromodulation effects on behavioral, imaging and physiological outcomes in projects 2 and 3. Beyond acquisition and analytic support, the RSC is designed to support critical cross-project data analyses. Cross-project synergy is essential to the overall SCORE research plan and built into the design of the projects. This will allow for interesting and potentially valuable pooled analyses of the data and will permit us to address larger-scale questions about sex differences in the neuroscience of the neural pathophysiological mechanisms responsible for autonomic dysregulation in major depression and sex differences in the effects of a novel transcutaneous vagal stimulation technique on the attenuation of these alterations.

项目概要 资源支持核心（RSC）将提供基础设施和工具，以实现统一的方法 SCORE 项目中数据的收集、分析、存储和共享。 RSC还将提供专家 在生物统计学、经皮迷走神经刺激等领域提供支持，并促进自主神经和神经系统的发展 神经影像分析。建立统一的方法可以提高所有研究的质量，使每个研究 项目以潜在重要的方式向其他人提供信息，并通过以下方式进行有价值的探索性分析 汇集多个项目收集的数据。 MRI 的非侵入性性质允许进行多种检查 对单个受试者进行的实验，无论是在一个考试期间还是在多个考试期间 场合，如当前提案中所提议的，以实现项目 1 和 2 的目标。成像数据 必须在空间和时间上准确记录，并解释以隔离生理现象 来自外部噪音源的兴趣。三维、高分辨率、解剖 MRI 图像将 为相互关联神经影像信息提供基础。广泛的功能成像分析工具 然后将用于询问静息大脑状态以及任务和/或刺激引起的区域激活。 我们提出的图像分析工具已经过研究人员的广泛测试和验证 Athinoula A. Martinos 生物医学成像中心，多年来。 RSC 将提供对此的访问 马蒂诺斯中心广泛的神经影像专业知识，并将提供一种可重复且有效的方法 获取、分析、测试结构和功能神经影像并将其与生理数据关联起来。 RSC 将 还通过制定和执行高级计划来提供生物医学信号处理支持 对动物和人类的生理测量进行数学建模和处理 实验。这将有助于对所探索的自主神经失调机制进行转化分析 项目 1 和 3。 专家在中实施非侵入性迷走神经刺激技术 人类和动物模型已纳入 RSC，并将协助实验设置和 解释迷走神经调节对项目中行为、成像和生理结果的影响 2 和 3. 除了采集和分析支持之外，RSC 还旨在支持关键的跨项目数据 分析。跨项目协同对于整个 SCORE 研究计划至关重要，并融入到 SCORE 的设计中 项目。这将允许对数据进行有趣且具有潜在价值的汇总分析，并允许 我们解决神经科学中有关性别差异的更大规模问题 导致重性抑郁和性自主神经失调的病理生理机制 新型经皮迷走神经刺激技术对这些衰减效果的差异 变更。