Non-invasive assessment and modulation of brain-gut interoception in humans

人类脑肠内感受的无创评估和调节

基本信息

批准号：
10591158
负责人：
VITALY NAPADOW
金额：
$ 27.27万
依托单位：
SPAULDING REHABILITATION HOSPITAL
依托单位国家：
美国
项目类别：
财政年份：
2023
资助国家：
美国
起止时间：
2023-04-01 至 2025-03-31
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10591158
关键词：
Adult Amygdaloid structure Animal Model Anterior Area Brain Brain Stem Brain imaging Brain region Breathing Calibration Cell Nucleus Cells Clinical Cross-Over Studies Esophagus Evaluation Feedback Food Four-dimensional Functional Gastrointestinal Disorders Functional Magnetic Resonance Imaging Gastrointestinal Diseases Gastrointestinal tract structure Goals Human Hypothalamic structure Image Individual Ingestion Insula of Reil Interoception Intervention Lead Link Magnetic Resonance Imaging Measures Mechanoreceptors Methods Molecular Muscle Tonus Nerve Nodose Ganglion Nucleus solitarius Organism Outcome Pathway interactions Peristalsis Physiology Pontine structure Process Proxy Randomized Rectum Relaxation Reporting Research Role Signal Transduction Single-Blind Study Source Spinal Stomach Techniques Thalamic structure Upper digestive tract structure Vagus nerve structure Vertebral column Visceral brain magnetic resonance imaging cingulate cortex cohort contrast enhanced dorsal motor nucleus experimental study gastrointestinal gut-brain axis improved insight kinematics mechanotransduction neural circuit neuroimaging neuroregulation novel parabrachial nucleus rectal response tool vagus nerve stimulation

项目摘要

PROJECT SUMMARY/ABSTRACT Interoception refers to the representation of the internal states of an organism, and includes the processes by which it senses, interprets, integrates, and regulates signals from within itself. Interoception is increasingly viewed as a bidirectional process between the brain and body, in which multiple feedback and feedforward loops lead to an internal representation of the body. The vagus nerve is intimately involved in autonomic control of the upper gastrointestinal (GI) tract, with afferent projections to medullary brainstem nuclei. In turn, interoceptive pathways can also be directly targeted for clinically beneficial neuromodulation and non-invasive neuromodulatory techniques that interact with brainstem vagal circuitry, including transcutaneous auricular vagal nerve stimulation (taVNS), have been reported to modulate efferent visceral vagal pathways via the engagement of nucleus tractus solitarii (NTS). However, broader understanding of taVNS effects on gastric function and brain response to gastric interoceptive signaling is needed, and requires tools to directly probe the gut-brain axis in humans. In our study, we will combine a fully non-invasive experimental framework including sequential gastric and brain Magnetic Resonance Imaging (MRI) with calibrated meal ingestion and MRI- compatible taVNS to evaluate the modulation of visceral interoception along the brain-gut axis. Aim 1 will evaluate gastric function and brain response to gastric interoceptive signaling following calibrated meal ingestion. In Aim 2, we will then investigate taVNS modulation of gastric function and brain response to gastric interoceptive signaling. The proposed study will contribute new insights into the bidirectional gut-brain interaction underlying gastric interoception, and its modulation via non-invasive neuromodulatory techniques that specifically target interoceptive pathways (i.e. taVNS).

项目概要/摘要内感受是指有机体内部状态的表征，包括以下过程：它感知、解释、整合和调节自身内部的信号。内感受越来越被视为大脑和身体之间的双向过程，其中多重反馈和前馈循环导致身体的内部表征。迷走神经与自主神经密切相关通过对髓质脑干核的传入投射来控制上胃肠道（GI）。反过来，内感受通路也可以直接针对临床有益的神经调节和非侵入性与脑干迷走神经回路相互作用的神经调节技术，包括经皮耳神经据报道，迷走神经刺激（taVNS）可通过调节内脏迷走神经传出通路孤立束核（NTS）的接合。然而，对 taVNS 对胃的影响的更广泛了解需要了解胃内感受信号的功能和大脑反应，并且需要工具来直接探测胃内感受信号人类的肠脑轴。在我们的研究中，我们将结合一个完全非侵入性的实验框架，包括连续胃部和脑部磁共振成像 (MRI)，校准膳食摄入和 MRI- 兼容的 taVNS 来评估沿脑肠轴内脏内感受的调节。目标1将评估校准膳食后胃功能和大脑对胃内感受信号的反应摄入。在目标 2 中，我们将研究 taVNS 对胃功能的调节以及大脑对胃的反应内感受信号传导。拟议的研究将为双向肠脑提供新的见解胃内感受的相互作用及其通过非侵入性神经调节技术的调节专门针对内感受通路（即 taVNS）。