Nanoparticle Synthesis and Characterization

纳米粒子的合成和表征

• 批准号: 9149663
• 负责人: Teresa J Porri
• 金额: $ 6.72万
• 依托单位: SLOAN-KETTERING INST CAN RESEARCH
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/9149663
• 关键词: Address; Boxing; Brain Neoplasms; Cancer Patient; Characteristics; Chemistry; Clinical; Coupled; Detection; Development; Diagnosis; Diagnostic; Drug Kinetics; Dyes; Educational workshop; Encapsulated; Equipment; Fluorescent Dyes; Funding; Gel Chromatography; Generations; Geometry; Goals; Heterogeneity; High Pressure Liquid Chromatography; Human; Hybrids; Image; Label; Lasers; Ligands; Lymph Node Mapping; Malignant Neoplasms; Medicine; Memorial Sloan-Kettering Cancer Center; Metastatic Melanoma; Methodology; Modality; Operative Surgical Procedures; Optics; Participant; Particle Size; Peptides; Polyethylene Glycols; Positron-Emission Tomography; Property; Protocols documentation; Radiation therapy; Radioisotopes; Research; Research Project Grants; Resource Sharing; Resources; Silicon Dioxide; Staging; Surface; System; Technology; Therapeutic; Therapeutic Index; Training; Translating; Translations; Vision; Water; Work; absorption; abstracting; advanced system; aluminosilicate; base; clinical investigation; feeding; improved; instrumentation; light scattering; member; nanomaterials; nanomedicine; nanoparticle; novel; oncology; particle; research study; theranostics; tool

SHARED RESOURCE CORE - NANOPARTICLE SYNTHESIS & CHARACTERIZATION CORE (CORE A) Project Abstract/Summary The vision of MC2TCN is to advance, translate, and disseminate a suite of ultrasmall (<10 nm) silica-organic hybrid nanoparticles for theranostics applications in oncology. In order to support the proposed research to achieve this overarching goal, the Shared Resources Core (SRC) on Nanoparticle Synthesis and Characterization (Core-A) will provide for particle synthesis and characterization investigations of clinical-grade C' dots and C rings with particle sizes below 10 nm. Particular focus of this Core will be to provide instrumentation and expertise in the analysis of heterogeneities in particle size and particle surface chemistry enabling studies in the Center on how these heterogeneities modulate pharmacokinetics (PK), clearance profiles, and target-to-background ratios, a key issue of nanomaterials in medicine but usually challenging to address. This will be accomplished by (1) addition of a high performance liquid chromatography (HPLC) system with particle specific detection equipment for particle separations based on surface chemistry, (2) addition of a gel permeation chromatography (GPC) system for particle separation based on particle size, (3) acquisition of lasers for optical experiments tuned to the absorption characteristics of dyes encapsulated into the various optical nanoparticles. Other equipment needed to synthesize and characterize Center-wide used nanoparticles already exist in the space at Cornell, where the Core will be located, and includes hood space, a glove box, a zeta-sizer, and dynamic light scattering. This core will serve all research projects (RP1-4) of the Center.

共享资源核心 - 纳米颗粒合成和表征核心（核心A） 项目摘要/摘要 MC2TCN的视野是推进，翻译和传播一套超湿（<10 nm）硅胶的套件 用于肿瘤学中治疗剂应用的混合纳米颗粒。为了支持拟议的研究 实现这一总体目标，纳米颗粒合成的共享资源核心（SRC） 表征（核心A）将提供临床级的颗粒合成和表征研究 C'点和c环，粒径低于10 nm。该核心的特别重点是提供 仪器和颗粒表面化学异质性分析方面的仪器和专业知识 在中心启用有关这些异质性如何调节药代动力学（PK）的研究 概况和目标与背景比，这是医学中纳米材料的关键问题，但通常具有挑战性 地址。这将通过（1）添加高性能液相色谱（HPLC）来实现 带有颗粒特异性检测设备的系统，用于基于表面化学的颗粒分离，（2） 基于粒径的颗粒分离凝胶渗透色谱（GPC）系统，（3） 收集激光器的光学实验，并调节染料的吸收特征 各种光学纳米颗粒。综合和表征中心范围所需的其他设备 纳米颗粒已经存在于核心将要位于的康奈尔的空间中，包括引擎盖空间，一个 手套箱，Zeta-Sizer和动态光散射。该核心将为所有研究项目（RP1-4）服务 中心。