International Mouse Strain Resource (IMSR)

国际小鼠品系资源 (IMSR)

• 批准号: 7343513
• 负责人: Janan T. EPPIG
• 金额: $ 13.48万
• 依托单位: JACKSON LABORATORY
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-04-15 至 2011-04-14
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7343513
• 关键词: Adopted; Alleles; American; Animal Model; Animals; Archives; Automation; Awareness; Back; Biological Models; Biomedical Research; Breeding; Budgets; Canada; Caring; Cataloging; Catalogs; Clinical; Clinical Investigator; Clinical Research; Commit; Communities; Complex; Computer software; Data; Data Set; Database Management Systems; Databases; Development; Disease model; ES Cell Line; Economics; Education; Embryo; Ensure; Ethylnitrosourea; European; Experimental Models; Face; Familiarity; Feedback; Fostering; Funding; Future; Gene Mutation; Genes; Genetic; Genetically Engineered Mouse; Genome; Germ Cells; Goals; Grant; Guidelines; Health; Human; Improve Access; Informatics; Information Resources; Information Technology; Institution; International; Internet; Knock-out; Laboratories; Laboratory mice; Learning; Letters; Life; Link; Maintenance; Mammalian Genetics; Medical Research; Medicine; Methods; Modeling; Mouse Strains; Mus; Mutagenesis; Mutant Strains Mice; Mutation; Nomenclature; Numbers; Phase; Phenotype; Pliability; Positioning Attribute; Public Health; Quality Control; Reporting; Research; Research Infrastructure; Research Personnel; Resolution; Resource Development; Resources; Role; Scientist; Site; Source; Standards of Weights and Measures; Structure; System; Techniques; Technology; Time; Translational Research; Transposase; United States National Institutes of Health; Update; Variant; Work; austin; biomedical informatics; design; digital; embryonic stem cell; feeding; human disease; improved; knock out mouse project; knockout gene; member; mouse genome; mouse model; mutant; mutant mouse model; new growth; new technology; outreach; programs; repository; software development; success; tool; usability; web interface

DESCRIPTION (provided by applicant): The goal of the International Mouse Strain Resource (IMSR) is to facilitate access to mouse resources and mouse models of human disease that are used for basic and translational research. The unique and pivotal role of IMSR is in unifying information about mouse resource holdings worldwide, including inbred, mutant, and genetically engineered mice maintained as breeding stock, cryopreserved embryos and gametes, and ES (embryonic stem) cell lines. At the IMSR website (www.imsr.org), users can search for mouse resources, locate strains for their research, learn details about a strain, contact a repository for ordering mice, and link to phenotype and disease model descriptions. Here, we propose to further develop the IMSR infrastructure and user interface: (1) to better represent gene trapped and targeted ES cell lines that will become a major resource type in the developing large-scale gene knockout projects; (2) to expand IMSR representation such that resources created using other new and developing technologies can be easily incorporated into IMSR; (3) to improve automation and reporting functions of the IMSR; (4) to enhance web content to provide user access to additional data; and (5) to improve web usability for translational and clinical researchers less familiar with mouse models. We will also support the critical IMSR curation activities to ensure that the data in IMSR continue to improve and are consistent with scientific community standards. This includes development of curation tools to enhance the ability of IMSR to utilize data from other online resources. It is imperative at this time, when many new unique mouse resources are rapidly expanding and new repositories are being established, that IMSR grow and change with the scientific community's progress and enhance its infrastructure to be positioned to fully support these new resource needs. Relevance to Public Health: Virtually all advances in human medicine rely on the use of animal models, and chief among these model systems is the laboratory mouse. The International Mouse Strain Resource (IMSR) is a publicly accessible online resource that assists the scientific community in finding information about worldwide mouse resources, locating the repositories from which they can be obtained, and ordering needed resources. Through IMSR users also can link to phenotype and disease model descriptions to evaluate and select the most appropriate experimental model for their research. The proposed enhancements to IMSR will improve access to thousands of new valuable mouse resources by enabling their inclusion as they are developed, by adding repository sites with unique mouse resource holdings, and by enhancing information content available to the user online.

描述（由申请人提供）： 国际小鼠应变资源（IMSR）的目的是促进用于基本和转化研究的人类疾病的小鼠资源和小鼠模型。 IMSR的独特而关键的作用在于统一有关全球小鼠资源持有的信息，包括将其保存为繁殖库存，冷冻保存的胚胎和配子以及ES（胚胎茎）细胞系的近交，突变和遗传工程小鼠。在IMSR网站（www.imsr.org）上，用户可以搜索鼠标资源，为其研究找到压力，学习有关应变的详细信息，与存储库联系以订购小鼠，并链接到表型和疾病模型描述。 在这里，我们建议进一步开发IMSR基础架构和用户界面：（1）更好地表示基因捕获和靶向的ES细胞系，这些基因将成为开发大型基因敲除项目的主要资源类型； （2）扩展IMSR表示形式，以便可以轻松地将使用其他新技术创建的资源纳入IMSR； （3）提高IMSR的自动化和报告功能； （4）增强Web内容以提供用户访问其他数据的访问； （5）为了提高转化和临床研究人员的Web可用性，对小鼠模型不熟悉。我们还将支持关键的IMSR策划活动，以确保IMSR中的数据继续改善，并且与科学社区标准一致。这包括开发策展工具，以增强IMSR利用其他在线资源的数据的能力。目前，当许多新的鼠标资源正在迅速扩展和建立新的存储库时，IMSR随着科学界的进步而发展并改变其基础架构以充分满足这些新资源需求的位置。与公共卫生有关：实际上，人类医学的所有进步都取决于动物模型的使用，在这些模型系统中，最主要的是实验室鼠标。国际鼠标应变资源（IMSR）是一种公开访问的在线资源，可帮助科学界找到有关全球鼠标资源的信息，找到可以从中获得的存储库，并订购所需的资源。通过IMSR用户还可以链接到表型和疾病模型描述，以评估和选择最合适的研究模型。提出的对IMSR的增强功能将通过添加具有唯一鼠标资源持有的存储库站点，并增强在线用户可用的信息内容，从而改善成千上万个新的有价值的鼠标资源的访问。