Core NIBS

核心NIBS

• 批准号: 10456007
• 负责人: VITALY NAPADOW
• 金额: $ 8.96万
• 依托单位: MASSACHUSETTS GENERAL HOSPITAL
• 依托单位国家: 美国
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-08-01 至 2024-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10456007
• 关键词: Address; Anatomy; Autonomic Dysfunction; Biometry; Biostatistics Core; Brain; Brain region; Centers of Research Excellence; Collection; Communities; Complementary Health; Consultations; Data; Data Analyses; Data Set; Databases; Distributed Databases; Ensure; Etiology; Functional Magnetic Resonance Imaging; Functional disorder; Funding; Glean; Heart; Human Resources; Image; Infrastructure; Institution; Integrative Medicine; Intervention; Investigation; Magnetic Resonance Spectroscopy; Meditation; Methods; Migraine; Mind-Body Intervention; Modeling; National Center for Complementary and Integrative Health; Neuroanatomy; Neurobiology; Outcome; Patients; Peripheral; Physiologic pulse; Positron-Emission Tomography; Protons; Resources; Rest; Signal Transduction; Standardization; Statistical Data Interpretation; Statistical Methods; Testing; Trigeminal System; base; body-mind; central sensitization; chronic pain; chronic painful condition; computerized data processing; data acquisition; data infrastructure; data sharing; data structure; database structure; functional MRI scan; heart rate variability; neuroimaging; neuroinflammation; neuroinformatics; neurophysiology; response; sensory input; sharing platform; synergism; tool; web portal

The Neuroimaging and Biostatistics (NIBS) Core will provide technical support to synthesize and integrate neuroimaging and statistical methods and analyses across the Center of Excellence for Research on Complementary and Integrative Health (CERCIH) Projects. The three Projects we propose aim to evaluate how combined top-down and bottom-up mind-body therapies boost neurophysiological response in migraine patients. By providing a common image acquisition and analysis framework, the NIBS Core will facilitate the ability to perform intra- and inter-project analyses as well as larger-scale analyses that integrate not only the CERCIH but other related NCCIH-funded studies at the institution, thus allowing us to address on a still broader scale questions about the neurobiology of mind-body therapies in chronic pain conditions, and thereby increase the value of such data to the broader community when shared according to our Data Sharing Plan. The Aims of the NIBS Core will be to optimize and integrate neuroimaging methods across the CERCIH Projects, which will cover ultrahigh field (7T) structural and functional MRI, positron emission tomography (PET), proton magnetic resonance spectroscopy (H-MRS), and combined heart rate variability (HRV) / fMRI scanning for assessment of the Central Autonomic Network (CAN). Aims will also provide unified, comprehensive data analysis and biostatistical / neuroanatomical support, organize a unified database and data-sharing infrastructure, and support exploratory analyses on combined datasets collected by all three Projects.

神经影像和生物统计学（NIBS）核心将为合成和整合提供技术支持 卓越研究中心的神经影像和统计方法及分析 补充和综合健康 (CERCIH) 项目。我们提出的三个项目旨在评估 自上而下和自下而上的身心疗法相结合如何增强偏头痛的神经生理反应 患者。通过提供通用的图像采集和分析框架，NIBS Core 将促进 能够执行项目内和项目间分析以及更大规模的分析，这些分析不仅集成了 CERCIH 以及该机构其他由 NCCIH 资助的相关研究，从而使我们能够继续讨论 关于慢性疼痛的身心疗法的神经生物学的更广泛的问题，从而 根据我们的数据共享计划共享此类数据，可以增加此类数据对更广泛社区的价值。 NIBS 核心的目标是优化和整合整个 CERCIH 的神经影像方法 项目将涵盖超高场 (7T) 结构和功能 MRI、正电子发射断层扫描 (PET)、质子磁共振波谱 (H-MRS) 和组合心率变异性 (HRV)/fMRI 扫描中央自主网络（CAN）的评估。目标还将提供统一、 全面的数据分析和生物统计/神经解剖学支持，组织统一的数据库和 数据共享基础设施，并支持对所有三个收集的组合数据集进行探索性分析 项目。