FLYBASE: A DROSOPHILA GENOMIC & GENETIC DATABASE

Flybase：果蝇基因组

• 批准号: 7371143
• 负责人: WILLIAM MARTIN GELBART
• 金额: $ 367.81万
• 依托单位: HARVARD UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1992
• 资助国家: 美国
• 起止时间: 1992-08-01 至 2008-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7371143
• 关键词: Alleles; Animal Model; Architecture; Biological; Biological Process; Biology; Cell Line; Cells; Chromosomes, Human, Pair 2; Class; Collection; Communities; Complex; Computer software; DNA; DNA Sequence; Data; Data Collection; Data Set; Databases; Deltastab; Depth; Disease; Distant; Drosophila genome; Drosophila genus; Drosophila melanogaster; Drosophilidae; Electronic Mail; Embryo; Engineering; Event; Evolution; Family; Feedback; Frequencies; Funding; Gene Expression Regulation; Genes; Genetic; Genetic Databases; Genome; Genomics; Goals; Grant; Human; Human Biology; Immune Sera; Insecta; International; Internet; Investigation; Literature; Location; Manuals; Maps; Mediating; Minority; Mission; Modeling; Molecular; Mutation; Nervous system structure; Organism; Pathway interactions; Phenotype; Population; Process; Production; Proteins; Reagent; Recording of previous events; Research; Research Infrastructure; Research Personnel; Resource Informatics; Resources; Role; Site; Software Tools; Structure; Surveys; Tissues; Transcript; Transgenic Organisms; Update; Variant; Whole Organism; Work; base; comparative; fly; functional genomics; fundamental research; gene function; genome sequencing; innovation; model organisms databases; mutant; open source; research study; size; tool

DESCRIPTION (provided by applicant): FlyBase is a database of the core genetic and genomic information on the major genetic model organism, the fruit fly, Drosophila melanogaster, and related organisms of the family Drosophilidae. D. melanogaster has been, and continues to be the pioneering organism in understanding the intricate interplay of genes and their encoded products to drive complex biological processes such as the formation of the body plan of an embryo or the wiring of the nervous system. The evidence that such complex biological events has an ancient origin, predating the split of the insect and vertebrate lineages, means that the fundamental studies on complex biological processes that are carried out in D. melanogaster directly impact on our understanding of comparable processes in human biology and disease. Indeed, the majority of human genes associated with disease have closely related genes in Drosophila. The very vibrant Drosophila research community continues to carry out a great deal of fundamental research, and it is imperative to the progress of the scientific community as a whole that there is a central resource that captures, organizes and presents this information in a way that is readily accessible not only to experts in the fly, but to the broader research community. FlyBase serves that role, and captures the primary information on the DNA sequence of the D. melanogaster genome and related genomes, as well as its encoded transcripts and proteins, classical and transgenic mutations, phenotypes, strain collections, etc. These data can be accessed as a public resource, without restriction, by means of the Internet or as bulk downloads, and are organized so that complex queries of the Drosophila literature and genome projects can be carried out. Specific goals for the next 5 years of the FlyBase project, based on information garnered from the scientific literature and from large-scale data producers, will include capture, organization and presentation of: (1) a comprehensive set of annotations attached to the Drosophila genomic sequence, both in terms of the encoded products as well as the sites on the DNA that mediate regulation of gene expression and the architecture of chromosomes, (2) information on the basic genetics of genes and their mutant alleles, and (3) the relationship of the fundamental genetic/genomic objects described in items 1 and 2 to each other, e.g., their location on chromosomal and sequence maps, their interactions to produce the regulatory circuitry of cells, tissues and whole organisms, their anatomical distribution, both spatially and temporally, and their variation in populations and phenotypic classes.

描述（由申请人提供）：Flybase是有关主要遗传模型生物，果蝇，果蝇Melanogaster以及果蝇科的相关生物的核心遗传和基因组信息的数据库。 D. melanogaster一直是并且继续是理解基因及其编码产品的复杂相互作用以驱动复杂生物学过程的先驱生物，例如形成胚胎的身体计划或神经系统的接线。 这种复杂的生物学事件具有古老的起源的证据，早于昆虫和脊椎动物谱系的分裂，这意味着，对Melanogaster中进行的复杂生物学过程的基本研究直接影响我们对人类生物学和疾病中可比过程的理解。 实际上，与疾病相关的大多数人基因在果蝇中具有密切相关的基因。 非常活跃的果蝇研究界继续进行大量的基础研究，而对于整个科学界的进步至关重要的是，有一个中心资源可以捕获，组织和介绍此信息，并以一种不仅可以易于访问的方式访问了苍蝇的专家，而且对苍蝇的专家也可以访问。 FlyBase serves that role, and captures the primary information on the DNA sequence of the D. melanogaster genome and related genomes, as well as its encoded transcripts and proteins, classical and transgenic mutations, phenotypes, strain collections, etc. These data can be accessed as a public resource, without restriction, by means of the Internet or as bulk downloads, and are organized so that complex queries of the Drosophila literature and genome可以进行项目。 基于从科学文献和大型数据生产者中获得的信息的未来5年的特定目标，包括捕获，组织和演示：（1）以下内容：（1）一组全面的注释果蝇基因组序列附加的一组注释，均应用编码的dna和dna的位置，以及在基本上构成了基本范围的基本范围（conse）。基因及其突变等位基因的遗传学，以及（3）项目1和2中所述的基本遗传/基因组对象的关系，例如，它们在染色体和序列图上的位置，它们的相互作用，它们的相互作用以产生细胞，组织和整个生物体的调节性回路，整个生物体的分布，以及它们的分布，以及它们的分布，以及它们的分布，以及它们的变异，以及它们的变异，并具有变化。