Training

训练

• 批准号: 7681638
• 负责人: LYNN M MATRISIAN
• 金额: $ 20.93万
• 依托单位: VANDERBILT UNIVERSITY
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/7681638
• 关键词: Academy; Advertising; Advocate; Appointment; Area; Arts; Award; Awareness; Basic Science; Biochemistry; Biological; Biological Sciences; Biology; Biomedical Engineering; Biomedical Research; Cancer Biology; Cancer Model; Cellular biology; Chemistry; Clinical; Communication; Communication Research; Communication Tools; Computer Simulation; Computer software; Development; Documentation; Education; Educational Curriculum; Educational process of instructing; Educational workshop; Engineering; Equation; Exposure to; Faculty; Fellowship Program; Fire - disasters; Funding; Future; General Population; Goals; Individual; Institution; Interdisciplinary Study; International; Journals; Laboratories; Learning; Libraries; Malignant Neoplasms; Mathematics; Mentors; Methodology; Minority; Modeling; Multimedia; Participant; Pharmacologic Substance; Physics; Postdoctoral Fellow; Proceedings and Conferences; Proceedings, Conference; Process; Production; Publications; Publishing; Purpose; Rain; Recruitment Activity; Research; Research Infrastructure; Research Personnel; Research Project Grants; Schools; Science; Series; Standards of Weights and Measures; Students; System; Television; Tennessee; Terminology; Title; Training; Training and Education; United States National Institutes of Health; Universities; Update; Validation; Visual; Washington; Week; Welts; Work; abstracting; animation; anticancer research; biomathematics; cancer cell; career; college; digital; experience; field study; high school; interest; lectures; mathematical model; medical schools; member; movie; open source; post-doctoral training; programs; prototype; symposium; tumor; tumor growth

5.4 Aim 4. Train a group of mathematicians, engineers and cancer biologists in the development and use of mathematical modeling of cancer invasion, as welt as develop courseware and open-source software products for use by such individuals at other institutions. The biomathematics training component at Vanderbilt will serve: Undergraduates, Graduate Students, Postdoctoral fellows and Faculty. Training will take place mainly in the Biomathematics Study Group and the Department of Cancer Biology. 5.4.t Goals Our goals are to: a. train mathematicians to interact with biologists by learning about their research problems and to become familiar with some basic principles and the terminology of biology and bo teach biologist to understand the mathematical modeling process so that they can help mathematicians formulate the models and provide the validation of these models. 5¿4.2 Undergraduate training Undergraduate training: a. incorporate simple mathematical models used in tumor research into the standard mathematical courses that are taken by undergraduate science and engineering majors (ordinary and partial differential equations, numerical computing); b. use cancer models in our biomathematics courses. A seminar type course will be added to the BSG curriculum that will focus on the mathematical modeling of tumors; e¿ have the undergraduates participate in Dr. Lou DeFeliee's undergraduate research experience. This program enhances the existing Biomathematics Study Group (BSG) curriculum and will assist in the development of the proposed Vanderbilt Interdisciplinary Educational Program (VIEP), a new framework for teaching and mentoring at Vanderbilt. The program is an entirely new undergraduate course, which will be taught by researchers from mathematics and the biological sciences. It places undergraduates into interdisciplinary research teams and pairs them with graduate students working in an interdisciplinary research groups. The program brings together biomedical researchers located primarily in the School of Medicine with biomathematics, biophysicists, and biomedical engineers. The program recruits freshman in the College of Arts and Science and continues throughout the student's undergraduate training. The purpose of the program is to direct talented undergraduates to careers in biomedical research; these students will enter graduate training with strong backgrounds in quantitative approaches to biomedical problems. A proposal to NIH has been submitted to fired this venture; do entice undergraduates to work in cancer laboratories in the existing summer research programs at Vaderbilt; eo share our undergraduate initiatives with Fisk University and Tennessee State University, two minority institutions in Nashville with which we have ties to both mathematical and biological departments at Vanderbilt. 5.4¿3 Graduate training Both Mathematics Graduate Students and Students from the VUMC Interdisciplinary Graduate Program (IGP) will be recruited into the Program. For the mathematics students, a curriculum is already in place whereby they take the standard mathematical courses (analysis, topology, algebra, etc) required of every graduate student in the Mathematics Department. In addition, they take courses in cell biology and biochemistry. To further enhance their exposure to the biological sciences, they rotate through laboratories and are jointly mentored by a faculty member from both the Department of Mathematics and a department in the biological sciences, including Cancer Biology. Similarly, IGP students in the School of Mediicine will take their standard courses and, in addition, they will be introduced to a five-step process for creating a mathematical model: (QAFSA) 1. ask the Question; 2. study the Approach: 3. Formulate the mathematical model; 4. Solve the model and 5. Answer the question. Ultimately, each student will be given a simple biological problem and will be asked to formulate a mathematical model for it. Where possible, we will team IGP and biomathematics graduate students to work on such problems thereby allowing each to learn from each other. Some of present IGP students are interested in learning more mathematics and we currently have two students from the IGP program that are taking traditional mathematics courses. We will also establish an Exchange Program for graduate students between Vanderbilt and the University of Dtmdee. This program will be between the Biomathematics Study Group at Vanderbilt and the SIMBIOS Center at the University of Dundee. 5.4.4 Post-Graduate training Post-doctoral Fellows will also be brought into the program through our ongoing practice ofhMng post-does coming out of programs such as mathematics, physics, chemistry, cell biology, cancer biology, physics, e_c. These appointments are interdisciplinary and are shared by departments. The post-docs will also be involved in t-raining the undergraduates. 5.4.5 Faculty training Training of FaculW will be accomplished in three ways. We will hold international symposia and workshops on alternating years. Both the symposia and workshops will be advertised in leading Cancer, Cell Biology, Mathematics and Biomathematies journals. a. Workshops will be organized to provide mathematicians with training in cancer biology and cancer biologists with training in mathematical modeling. Each workshop will consist of lectures and demonstrations by invited experts in topics fundamental to the interdisciplinary development of mathematical modeling of rumors. The workshops will be open to participants from graduate m advanced career levels. A prototype organization of such a workshop is given below. The Workshop will be small (30 or less participants) gatherings that bring together mathematicians, physicists, engineers, and biologists and are intended to educate researchers that are new to field of cancer modeling. The workshops will be didactic and the faculty will come from Vanderbilt arid other institutions b. Symposia will be held using the infrastructure of the Vanderbilt University Summer Program. The symposia will be for mathematicians and cancer biologists to present current research to an interdisciplinary audience. The conferences will be modeled on the conference held at Vanderbilt May 2-5, 2002. The conference, entitled Mathematical Models in Cancer, was devoted to the development, analysis, and computer simulation of continuous and discrete models of tumor growth and treatment. Details of the program are available at: htt_p://math.vanderbilt.edu/~horn/biomath/cancerrnain.html. The participants included mathematicians, cancer biologists, clinicians, and pharmaceutical researchers. The proceedings of the conference were published as a special issue of the journal Discrete and Continuous Dynamical Systems, Vol.4, No. 1, 2004 (abstracts and titles appended). Similar organization and format will be used for conferences planned as part of this proposal. A primary goal will be to involve both mathematicians and biologists in the convergence of methodologies of tumor mode1 research. e. Fellowship Programs (1-2 years) to reu'am mathematicians in cancer research. 5,4.6 Dissemination of Program for All In order to attract candidates to the program, we will a. construct a website that contains: Statement of purpose Research groups Downloadable publications On-line animations of our models Meetings/workshops Education material b. develop multimedia presentation using the Office of Science & Research Communications at Vanderbilt. These products (e.g., movies) will use to publicize the work of the group to the general public and Co make available members of our group to make non-technical presentations to students (primarily high school and undergraduate) about the research projects that involve the coming together of mathematics and biology. do advertise the Program in Cancer. Ce!i Bioiogy and Mathematics arid Biomathematics journals 5M¿7 Multimedia presentations We will produce multimedia presentations that highlight the activities of this project for the general public, the classroom, and the professional (clinical and basic research). These presentations will be in different formats depending on the need of the target audience, including broadcast digital beta sp, vhs, DVD, Quicktime movies, etc. Presentations will be produced for video and DVD distribution, as well as appropriate material digitized and downloadable from the program website. In addition, feature stories will be submitted to local and national broadcast television outlets as well as relevant professional journals including Exploration, the online research journal of Vanderbilt University, (http://exploration.vanderbilt.edu/l. The board of advisors for this award-winning journal includes members of the National Academy and Nobel laureates, prominent science journalists from prestigious media outlets such as the Washington Post and Nova/WGBH. Utilizing the experience and connections of our visual communications director, Kathy Conkwright, as weI1 as the Exploration board of advisors, a broadcast feature documentary will be produced highlighting this project should be broadly distributed in many different areas and formats. All relevant activities of this project will be turned into visual communications tools to be used in a variety of capacities including training and recruiting students and post-does, as well as educating and informing faculty and the general public. Planned productions include: Visual documentation of relevant panels, presentations and conferences; Produced and edited DVD series of week-long yearly workshop; ¿ 3 produced and updated training and education videos that target, respectively, experimental biologists, mathematicians and laymen; * Broadcast quality documentary to be distributed to national public television, cable television, universities and public libraries, to increase awareness and support regarding issues of cancer research including its scope, pace, advances and potential funding. In addition, the program will strive to recruit advocates and future professionals, as well as popularize this field of study as a critical advance in the battle against cancer.

5.4 AIM 4。培训一组数学家，工程师和癌症生物学家在开发中 使用癌症入侵的数学建模，如开发课程和开源 这些个人在其他机构使用的软件产品。 范德比尔特（Vanderbilt）的生物学培训组成部分将服务：本科生，研究生，博士后 研究员和教师。培训将主要发生在生物学研究小组和 癌症生物学系。 5.4.T目标 我们的目标是： 一个。培训数学家通过学习研究问题并成为生物学家互动 熟悉一些基本原则以及生物学的术语和 BO教师生物学家了解数学建模过程，以便他们可以帮助数学家 制定模型并提供这些模型的验证。 5�4.2本科培训 本科培训： 一个。在肿瘤研究中使用的简单数学模型纳入标准数学课程 由本科科学和工程专业（普通和部分微分方程， 数值计算）; b。在我们的生物学课程中使用癌症模型。 BSG将添加一个开创性的课程 课程将集中于肿瘤的数学建模； E»让本科生参与Lou DeFeliee博士的本科研究经验。这 计划增强了现有的生物制作研究小组（BSG）课程，并将协助 开发拟议的范德比尔特跨学科教育计划（VIEP），这是一个新框架 在范德比尔特进行教学和心理化。该计划是一门全新的本科课程，将 由数学和生物科学的研究人员教授。它将本科生放入 跨学科研究团队并将他们与在跨学科工作的研究生配对 研究小组。该计划汇集了主要位于学校的生物医学研究人员 具有生物学，生物物理学家和生物医学工程师的医学。该计划报告新生 艺术与科学学院在整个学生的本科培训中继续进行。目的 该计划的工作是将有才华的本科生指导生物医学研究的职业；这些学生将进入 具有强大背景的生物医学问题方法的研究生培训。提出的建议 NIH已提交给这项企业； 是否会吸引本科生在现有的夏季研究计划中从事癌症实验室的工作 瓦德比尔特； EO与菲斯克大学和田纳西州立大学分享我们的本科倡议 纳什维尔的机构与我们与数学和生物部门有联系 范德比尔特。 5.4¿3研究生培训 数学研究生和来自VUMC跨学科研究生的学生 计划（IGP）将招募到该计划中。对于数学专业的学生，​​课程已经在 他们参加了所需的标准数学课程（分析，拓扑，代数等）的地方 数学系的每个研究生。此外，他们参加了细胞生物学和 生物化学。为了进一步增强其对生物科学的接触，它们通过实验室旋转 并由数学系和一个部门的教职员工共同修复 生物科学，包括癌症生物学。同样，Mediicine学校的IGP学生将 参加他们的标准课程，此外，他们将被介绍到一个五步过程中，以创建一个 数学模型：（QAFSA）1。提出问题； 2。研究方法：3。制定数学 模型; 4。解决模型和5。回答问题。最终，每个学生都将得到一个简单的 生物学问题，并将被要求为其制定数学模型。在可能的情况下，我们会 IGP团队和生物学研究生解决此类问题，从而允许每个人学习 彼此。目前的一些IGP学生有兴趣了解更多数学，我们目前 来自IGP计划的两个学生正在参加传统的数学课程。 我们还将为范德比尔特和大学之间的研究生建立一个交流计划 DTMDEE。该计划将在范德比尔特的生物学研究小组和Simbios之间 邓迪大学中心。 5.4.4研究生培训 博士后研究员也将通过我们正在进行的练习后的练习来参加该计划 来自数学，物理，化学，细胞生物学，癌症生物学，物理学，E_C等计划。 这些任命是跨学科的，由部门共享。邮政邮政也将参与 在t缩小本科生中。 5.4.5教师培训 Faculw的培训将通过三种方式完成。我们将举行国际研讨会和研讨会 在替代年份。研讨会和研讨会都将在领先的癌症，细胞生物学， 数学和生物心理期刊。 一个。研讨会将组织为数学家提供癌症生物学和癌症的培训 生物学家在数学建模方面接受培训。每个研讨会将由讲座和 主题专家的示威活动是跨学科发展的基础 橡胶的数学建模。这些研讨会将向大学的参与者开放 职业水平。下面给出了这样一个研讨会的原型组织。研讨会很小（30 或更少的参与者）聚会，将数学家，物理学家，工程师和生物学家汇集在一起 旨在教育癌症建模领域的研究人员。讲习班将是教学的 教师将来自范德比尔特干旱其他机构 b。座谈会将使用范德比尔特大学夏季计划的基础设施举行。这 研讨会将使数学家和癌症生物学家向跨学科提出当前的研究 观众。这些会议将在2002年5月2日至5日在范德比尔特举行的会议上进行仿真。这些会议将在2002年5月2日至5日在范德比尔特举行的会议上进行仿真。 会议，标题为癌症的数学模型，已部署到开发，分析和 计算机模拟肿瘤生长和治疗的连续和离散模型。细节 程序可在以下网址获得：htt_p：//math.vanderbilt.edu/~horn/biomath/cancerrnaiin.html。参与者 包括数学家，癌症生物学家，临床医生和制药研究人员。会议记录 该会议是作为离散和连续动态系统期刊的特刊发表的， 第4卷，第1期，2004年（附加摘要和标题）。类似的组织和格式将用于 会议计划是本提案的一部分。主要目标是让两位数学家和 肿瘤模式研究方法收敛的生物学家。 e。奖学金计划（1 - 2年）曾在癌症研究中为REU'AM数学家提供奖学金。 5,4.6所有计划的计划 为了吸引候选人参加该计划，我们将 一个。构建一个包含的网站： 目的声明 研究小组 可下载的出版物 我们模型的在线动画 会议/讲习班 教育材料 b。使用范德比尔特科学与研究通信办公室开发多媒体演讲。 这些产品（例如，电影）将用来向公众公开该小组的工作，并 CO让我们小组的成员向学生（主要高）进行非技术演讲 学校和本科生）关于涉及数学和数学结合在一起的研究项目 生物学。 在癌症方面做广告。 CE！我生物学和数学干旱生物学期刊 5m€7多媒体演示 我们将制作多媒体演讲，以突出该项目的活动， 教室和专业人士（临床和基础研究）。这些演示文稿将不同 格式取决于目标受众的需求，包括广播数字Beta SP，VHS，DVD， QuickTime电影等。将制作用于视频和DVD发行的演示文稿，以及 适当的材料从程序网站进行数字化和下载。此外，功能故事还将 被提交给本地和国家广播电视媒体以及相关的专业期刊 包括探索，范德比尔特大学在线研究杂志， （http://exploration.vanderbilt.edu/l。屡获殊荣的期刊顾问委员会包括成员 美国国家学院和诺贝尔奖获得者，来自著名媒体的著名科学记者 例如《华盛顿邮报》和Nova/WGBH。利用我们视觉的经验和联系 传播总监凯西·康克赖特（Kathy Conkwright）作为wei1作为顾问委员会，广播 将制作功能纪录片，突出显示该项目应大致分布在许多 不同的区域和格式。 该项目的所有相关活动都将变成视觉通信工具，用于多种多样 包括培训和招募学生和术后的能力，以及教育和通知 教师和公众。计划作品包括： 相关面板，演示和会议的视觉文档； 为期一周的年度研讨会制作并编辑了DVD系列； „ 3分别针对实验的培训和教育视频，制作和更新 生物学家，数学家和外行； *广播质量纪录片将分发给国家公共电视，有线电视， 大学和公共图书馆，以提高人们对癌症问题的认识和支持 研究包括其范围，空间，进步和潜在资金。此外，该程序将 努力招募倡导者和未来的专业人士，以及流行的这一研究领域 在与癌症的斗争中的重要进步。