Proteolytic Beacons in the Non-invasive Assessment of Response to Cancer Therapy
蛋白水解信标在癌症治疗反应无创评估中的应用
基本信息
- 批准号:7490272
- 负责人:
- 金额:$ 10.45万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2008
- 资助国家:美国
- 起止时间:2008-09-22 至 2013-08-31
- 项目状态:已结题
- 来源:
- 关键词:AEE 788Angiogenic FactorAnimalsAntibodiesBenignBiological AvailabilityBiometryBiostatistics CoreCell physiologyCellsCetuximabChemicalsChemistryChemotherapy-Oncologic ProcedureCleaved cellClinicalCollaborationsColorectal CancerComplementContrast MediaDataDepthDetectionDevelopmentDoseDyesEndopeptidasesEnergy TransferEnzymesEpidermal Growth Factor ReceptorEpidermal Growth Factor Receptor Tyrosine Kinase InhibitorEvaluationExperimental DesignsFamilyFamily memberFluorescenceGadoliniumGelatinase BGenerationsGoalsGrowth FactorHuman ResourcesImageIn VitroInfiltrationInflammatoryIntestinal NeoplasmsIntestinesInvasiveKnowledgeLaboratoriesLiteratureLiverMMP9 geneMagnetic Resonance ImagingMalignant - descriptorMalignant NeoplasmsMatrix MetalloproteinasesMediatingMetabolismMetalloendopeptidasesMetalloproteasesMicroscopyModelingMolecularMonitorMusNeoplasm MetastasisObject AttachmentOpticsPTK787Peptide HydrolasesPeptidesPhysiologyPlayProbabilityProteinsReadingReagentRegulationReporterResearchResearch PersonnelResolutionResourcesRoleSU11248SeriesSignal PathwaySolubilityStandards of Weights and MeasuresStatistical Data InterpretationSurrogate MarkersSystemTestingTherapeutic StudiesTimeTissuesToxic effectTrainingTumor Cell InvasionTumor VolumeTyrosine Kinase InhibitorVascular Endothelial Growth Factor ReceptorVertebral columnXenograft Modeladenomaaqueousbasecancer carecancer therapycellular imagingchemotherapeutic agentchemotherapycomplement C2adesignexperienceimaging probein vivoin vivo Cellular and Molecular Imaging Centersinhibitor/antagonistinterestmembermetastatic colorectalmouse modelnoveloptical imagingoptical switchresearch studyresidenceresponsesizetumortwo-photon
项目摘要
Project 4, led by Drs. Lynn Matrisian and Wellington Pham, focuses on developing optical beacons and MRI
contrast agents for the in vivo detection of tumor-associated metalloproteinase activity as a novel mechanism
to monitor response to tumor therapy. Members of the matrix metalloproteinase (MMP) family are implicated in
the matrix degradation associated with cancer invasion. There is substantial literature indicating the
involvement of specific MMP family members in specific cellular processes related to cancer, including the
activation of growth factors, angiogenesis, infiltration of inflammatory cells, and invasion. These investigators
propose to take advantage of this knowledge to devise a series of non-invasive in vivo imaging reagents that
will probe the proteolytic status of a tumor to aid in treatment decisions, and rapidly assess the response to
standard and targeted cancer chemotherapies. Dr. Pham, a chemist by training, brings extensive experience
with the design and synthesis of optical probes for proteolytic activity, and Dr. Matrisian, a cancer biologist, has
extensive experience exploring the role of metalloproteinases in mouse models of cancer. Murine models of
benign, malignant, and metastatic colorectal cancer will be used in this project, and the response to cancer
therapies directed at the epidermal growth factor (EGF) receptor axis will be tested in collaboration with
projects 1 and 3 of this ICMIC proposal.
项目 4,由博士领导。 Lynn Matrisian 和 Wellington Pham,专注于开发光学信标和 MRI
用于体内检测肿瘤相关金属蛋白酶活性的造影剂作为一种新机制
监测对肿瘤治疗的反应。基质金属蛋白酶 (MMP) 家族的成员参与
与癌症侵袭相关的基质降解。有大量文献表明
特定 MMP 家族成员参与与癌症相关的特定细胞过程,包括
生长因子的激活、血管生成、炎症细胞的浸润和侵袭。这些调查人员
建议利用这些知识来设计一系列非侵入性体内成像试剂
将探测肿瘤的蛋白水解状态以帮助做出治疗决策,并快速评估对肿瘤的反应
标准和靶向癌症化疗。 Pham 博士是一名化学家,拥有丰富的经验
癌症生物学家 Matrisian 博士设计并合成了用于蛋白水解活性的光学探针
探索金属蛋白酶在小鼠癌症模型中的作用的丰富经验。小鼠模型
该项目将使用良性、恶性和转移性结直肠癌,以及对癌症的反应
针对表皮生长因子(EGF)受体轴的疗法将与以下机构合作进行测试
ICMIC 提案的项目 1 和 3。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
数据更新时间:{{ journalArticles.updateTime }}
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
数据更新时间:{{ journalArticles.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ monograph.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ sciAawards.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ conferencePapers.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ patent.updateTime }}
LYNN M MATRISIAN其他文献
LYNN M MATRISIAN的其他文献
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
{{ truncateString('LYNN M MATRISIAN', 18)}}的其他基金
Molecular Mechanisms of SKP2 Targeting on Prostate Cancer Progression
SKP2靶向前列腺癌进展的分子机制
- 批准号:
8340131 - 财政年份:2011
- 资助金额:
$ 10.45万 - 项目类别:
A Multi-Center Epidemiologic Study of Breast Cancer in African-American Women
非裔美国女性乳腺癌多中心流行病学研究
- 批准号:
8340436 - 财政年份:2011
- 资助金额:
$ 10.45万 - 项目类别:
Paracrine TGF-Beta Signaling in Tumor Initiation and Progression
肿瘤发生和进展中的旁分泌 TGF-β 信号转导
- 批准号:
7289826 - 财政年份:2006
- 资助金额:
$ 10.45万 - 项目类别:
相似国自然基金
负载类血管生成因子3的可注射水凝胶局部控释体系构建及其对糖尿病下肢缺血病变的治疗作用
- 批准号:51973125
- 批准年份:2019
- 资助金额:58 万元
- 项目类别:面上项目
AGGF1-SIRT2轴通过调控自噬抑制肾癌发生的分子机制研究
- 批准号:81902860
- 批准年份:2019
- 资助金额:20.5 万元
- 项目类别:青年科学基金项目
LncRNA-NEAT1通过ceRNA作用促进卵巢癌血管新生的机制研究
- 批准号:81860515
- 批准年份:2018
- 资助金额:34.8 万元
- 项目类别:地区科学基金项目
血管生成因子AGGF1在机体抗DNA病毒天然免疫中的作用及调控机制
- 批准号:81801556
- 批准年份:2018
- 资助金额:22.0 万元
- 项目类别:青年科学基金项目
IL-21致KC分泌促血管生成因子调控银屑病微血管异常增生的机制研究
- 批准号:81703130
- 批准年份:2017
- 资助金额:20.0 万元
- 项目类别:青年科学基金项目
相似海外基金
Phthalate Exposure and Mechanisms of Action in the Neonatal Intensive Care Unit
新生儿重症监护病房中邻苯二甲酸盐的暴露及其作用机制
- 批准号:
10736301 - 财政年份:2023
- 资助金额:
$ 10.45万 - 项目类别:
Defining pro-metastatic and endothelial-regulatory roles for LIN28B in hepatocellular carcinoma
定义 LIN28B 在肝细胞癌中的促转移和内皮调节作用
- 批准号:
10865508 - 财政年份:2023
- 资助金额:
$ 10.45万 - 项目类别:
Metabolic Reprogramming of the Adult heart to a Regenerative State
成人心脏代谢重编程至再生状态
- 批准号:
10562415 - 财政年份:2023
- 资助金额:
$ 10.45万 - 项目类别:
A novel approach for prevention of Bronchopulmonary dysplasia in at-risk pre-term infants
预防高危早产儿支气管肺发育不良的新方法
- 批准号:
10765750 - 财政年份:2023
- 资助金额:
$ 10.45万 - 项目类别: