CORE-- BIOLOGICAL MEASURES

核心——生物措施

• 批准号: 7575134
• 负责人: ANDREW L ALEXANDER
• 金额: $ 18.76万
• 依托单位: UNIVERSITY OF WISCONSIN-MADISON
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-01-01 至 2008-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7575134
• 关键词: Address; Animals; Area; Biological; Biological Assay; Class; Data; Data Collection; Development; Diffusion; Functional Magnetic Resonance Imaging; Head; Hormonal; Image; Image Analysis; Laboratories; Literature; Localized; MRI Scans; Magnetic Resonance Imaging; Measures; Methods; Morphologic artifacts; Neurosecretory Systems; Operative Surgical Procedures; Positioning Attribute; Protocols documentation; Psychophysiology; Research Project Grants; Signal Transduction; Study Subject; Techniques; Testing; Training; base; data acquisition; human SLPI protein; improved; laboratory facility; method development; morphometry; neuroimaging; nonhuman primate; programs; psychologic; quality assurance

The biological measures core will provide support for the scientific projects in three main areas - (1) MRI and microPET imaging of study subjects, (2) data collection and analysis methods neuroendocrine (hormonal) measures obtained from study subjects, and (3) data collection and analysis methods for psychophysiological measures on study subjects. The core will be responsible for maintaining protocols, hardware and analysis methods that are necessary for the projects. The core will also provide training to project staff in data acquisition and analysis methods in each of the three domains (neuroimaging, neuroendocrine and psychophysiological measures). Regular quality assurance programs will be implemented. In addition, the imaging portion of the core will be responsible for developing new image acquisition and image analysis methods that will improve the imaging sensitivity, decrease image artifacts (distortion and localized signal loss in functional MRI scans), and improve animal imaging methods for both MRI and microPET.

生物学度量核心将为三个主要领域的科学项目提供支持 - （1）研究对象的MRI和MIRPET成像，（2）数据收集和分析方法神经内分泌（荷尔蒙）措施从研究对象获得，以及（3）研究受试者的心理生理测量方法的数据收集和分析方法。核心将负责维护项目所需的协议，硬件和分析方法。核心还将为项目人员提供三个领域中每个领域的数据获取和分析方法的培训（神经成像，神经内分泌和心理生理学 措施）。将实施定期的质量保证计划。此外，核心的成像部分将负责开发新的图像采集和图像分析方法，这些方法将提高成像敏感性，降低图像伪影（功能性MRI扫描中的失真和局部信号损失），并改善MRI和MIRI和MICROPET的动物成像方法。