PS07-003, Minority HIV/AIDS Research Initiative (MARI)

PS07-003，少数群体艾滋病毒/艾滋病研究计划 (MARI)

• 批准号: 7497086
• 负责人: GUILLERMO PRADO
• 金额: $ 21.62万
• 依托单位: UNIVERSITY OF MIAMI SCHOOL OF MEDICINE
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-09-30 至 2011-09-29
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7497086
• 关键词: PS07; 003; Minority; HIV; AIDS

DESCRIPTION (provided by applicant): The proposed study's overarching goal is to reduce the ethnic disparities in HIV infection between Hispanic and non-Hispanic youth living in Miami-Dade County, an HIV epicenter. This goal will be accomplished by two aims: AIM 1 is to develop and manualize a one-and-a-half- month streamlined version of an efficacious HIV preventive intervention entitled Familias Unidas; and AIM II is to evaluate the efficacy of the streamlined version of Familias Unidas plus an HIV Prevention School CurriculumTreatment as Usual, relative to the HIV Prevention School Curriculum Treatment as Usual only, in preventing drug use and unprotected sexual behavior, two risk factors for HIV infection. Familias Unidas aims to prevent drug use and unprotected sexual behavior by (a) increasing family functioning, (b) increasing parental monitoring of peer activities, and (c) influencing adolescent social cognitive mechanisms regarding drug use and unsafe sexual behavior. A sample of 240 Hispanic 9th grade adolescents and their primary caregivers will be randomized to one of two conditions: Familias Unidas plus the HIV School Curriculum Treatment as Usual (hereafter refererred to as Familias Unidas) or the HIV Prevention School Curriculum Treatment as Usual only. Two studies have demonstrated the efficacy of an intensive, 9 to 12 month version of Familias Unidas. In the first study, Familias Unidas was shown to be efficacious relative to a no- intervention control condition in increasing family functioning. In the second study, Familias Unidas was found to be efficacious in preventing drug use and unsafe sexual behavior relative to two attention control conditions. Hierarchical Linear Modeling (HLM) will be used to test: (H1) Familias Unidas will be more efficacious than the HIV Prevention School Curriculum Treatment as Usual in preventing adolescent drug use over time and (H2) Familias Unidas will be more efficacious than the HIV Prevention School Curriculum Treatment as Usual in preventing adolescent unprotected sexual behavior over time. Additionally HLM will be used to determine whether (H1a) the effect of Familias Unidas on drug use will be partially mediated by (1) family functioning; (2) parental monitoring of peers; and (3) social cognitive mechanisms regarding drug use; and (H2a) the effect of Familias Unidas on unprotected sexual behavior will be partially mediated by (1) family functioning; (2) parental monitoring of peers; (3) social cognitive mechanisms regarding unprotected sex; and (4) drug use. The objective of the proposed study is to reduce HIV contraction health disparities in Hispanic populations. The knowledge expected to be gained from this study will aid in the development of interventions to reduce drug use, unprotected sexual behavior, and HIV in Hispanic adolescents.

描述（由申请人提供）： 拟议的研究的总体目的是减少居住在艾滋病毒震中迈阿密戴德县的西班牙裔和非西班牙裔青年之间艾滋病毒感染的种族差异。这个目标将通过两个目标来实现：目标1是开发和手动使一个半月的简化版本的有效的艾滋病毒预防性干预措施为“ Familias Unidas”；目标II是在像往常一样与艾滋病毒预防学校课程治疗相比，将简化版本的Familias Unidas和HIV预防学校课程的功效评估，仅在预防药物使用和未经保护的性行为方面，这是HIV感染的两个危险因素。 Familias Unidas旨在通过（a）增加家庭功能，（b）增加父母对同伴活动的监测以及（c）影响青少年社会认知机制和不安全性行为的青少年社会认知机制，以防止使用药物使用和无保护的性行为。 240个西班牙裔9年级青少年及其主要护理人员的样本将被随机分为两个条件之一：Familias unidas以及像往常一样（以下称为Familias unidas）或HIV预防学校课程的样本或HIV学校课程治疗或艾滋病毒预防学校课程治疗。两项研究证明了一个密集的9到12个月版的Familias Unidas的功效。在第一项研究中，与不干预控制条件相比，Familias Unidas在增加家庭功能方面是有效的。在第二项研究中，发现Familias Unidas在防止药物使用和相对于两个注意控制条件的不安全行为有效。层次线性建模（HLM）将用于测试：（H1）Familias Unidas将比HIV预防学校课程像往常一样有效，以防止随着时间的推移预防青春期药物的使用，而（H2）Familias unidas将比HIV预防预防的学校课程治疗更有效，因为它是预防性预防性的，以预防适应性的性能过高的行为，以预防性地过度地促进了这种行为。另外，HLM将用于确定（H1a）Familias Unidas对药物使用的影响是否将由（1）家庭功能部分介导； （2）父母对同龄人的监测； （3）有关药物使用的社会认知机制； （H2a）Familias Unidas对不受保护的性行为的影响将由（1）家庭功能部分介导； （2）父母对同龄人的监测； （3）关于不受保护的性别的社会认知机制； （4）吸毒。拟议的研究的目的是减少西班牙裔人群中的HIV收缩健康差异。预计将从这项研究中获得的知识将有助于开发干预措施，以减少西班牙裔青少年的药物使用，未受保护的性行为和HIV。