CCR7 Chemotaxis Regulates Memory T Cell Localization

CCR7 趋化性调节记忆 T 细胞定位

基本信息

批准号：
10341145
负责人：
CHARLOTTE M VINES
金额：
$ 37.75万
依托单位：
UNIVERSITY OF TEXAS EL PASO
依托单位国家：
美国
项目类别：
财政年份：
2015
资助国家：
美国
起止时间：
2015-07-01 至 2024-01-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10341145
关键词：
Adoptive Transfer Antibodies Antibody Formation Antibody titer measurement Antibody-Producing Cells Antigens Autoimmune Diseases B-Cell Activation B-Lymphocytes Biological Assay Bone Marrow CC chemokine receptor 7 CD4 Positive T Lymphocytes CXC Chemokines CXCL12 gene Cell Compartmentation Cell Surface Proteins Cell physiology Cells Chemotaxis Data Dendritic Cells Event Exposure to Goals Homing Human Immune Immune response Immune system Immunity Immunoglobulin Class Switching Immunologic Memory Immunosuppression In Vitro Individual Knockout Mice Knowledge Life Ligands Link Major Histocompatibility Complex Measures Memory Memory B-Lymphocyte Migration Assay Molecular Mus Pathogenicity Pathway interactions Pattern Pattern recognition receptor Peptides Plasma Play Population Proteomics Regulation Regulatory T-Lymphocyte Role Signal Transduction Site Spleen T memory cell T-Cell Proliferation T-Lymphocyte Tissues Up-Regulation Vaccines Work adaptive immune response antagonist beta-Chemokines chemokine chemokine receptor conditional knockout effector T cell exposed human population falls gamma-Chemokines improved in vitro Assay in vivo lymph nodes migration novel pathogen prevent receptor response targeted treatment therapeutic target trafficking vaccine efficacy

项目摘要

ABSTRACT When humans are exposed to a substance that causes an immune response, to protect the itself, the body generates antibodies. There is very little understood about the role of chemokines in regulating the extent of the immune response, as measured by antibody titers and types of antibodies that are made. We have found that C-C chemokine receptor 7 regulates the antibody titers by controlling the localization of different populations of immune cells to the bone marrow. In this proposal our goal is to better understand the molecular mechanisms that are employed by immune T cells to respond to C-C chemokine receptor 7 activation that regulate the targeting of T cells to the bone marrow where they regulate the isotype switching and antibody production by immune cells. Our study is important since these antibodies protect the host when he or she is exposed to the same substance during a secondary immune response. We hypothesize that CCR7 regulates the migration of memory T, and regulatory T cells to the bone marrow to limit the activation of B cells during an adaptive immune response. With the knowledge we gain we will determine if redirection of the T cells can be applied to inhibit excessive immune responses observed during autoimmune diseases.

摘要当人类接触到引起免疫反应的物质时，为了保护自身，身体产生抗体。人们对趋化因子在调节趋化因子中的作用知之甚少。免疫反应的程度，通过抗体滴度和产生的抗体类型来衡量。我们发现 C-C 趋化因子受体 7 通过控制抗体的定位来调节抗体滴度不同群体的免疫细胞进入骨髓。在本提案中，我们的目标是更好地理解免疫 T 细胞响应 C-C 趋化因子受体 7 的分子机制调节 T 细胞靶向骨髓的激活，在骨髓中调节同种型转换以及免疫细胞产生抗体。我们的研究很重要，因为这些抗体可以保护宿主他或她在二次免疫反应期间接触到相同的物质。我们假设 CCR7 调节记忆 T 细胞和调节性 T 细胞向骨髓的迁移，以限制适应性免疫反应期间的 B 细胞。根据我们获得的知识，我们将确定是否重定向 T细胞可用于抑制自身免疫性疾病期间观察到的过度免疫反应。