Center for Biomedical Research Excellence, Epigenomics of Development and Disease

卓越生物医学研究中心，发育与疾病表观基因组学

• 批准号: 8432640
• 负责人: ROXANNE A VAUGHAN
• 金额: $ 236.83万
• 依托单位: UNIVERSITY OF NORTH DAKOTA
• 依托单位国家: 美国
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-09-10 至 2018-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8432640
• 关键词: Address; Aging; Antineoplastic Agents; Biochemical; Bioinformatics; Cardiovascular Diseases; Centers of Research Excellence; ChIP-seq; Collaborations; Commit; Communities; Complex; Computational Biology; Core Facility; Development; Disease; Disease model; Drug Addiction; Educational workshop; Ensure; Epigenetic Process; Equipment; Etiology; Extramural Activities; Faculty; Focus Groups; Fostering; Funding; Goals; Grant; Growth; Incidence; Individual; Inheritance Patterns; Lead; Libraries; Link; Mentors; Methylation; Mission; Modeling; Molecular; North Dakota; Phase; Play; Postdoctoral Fellow; RNA Sequences; Recruitment Activity; Regulation; Research; Research Infrastructure; Research Personnel; Research Project Grants; Research Support; Risk Factors; Role; Rural Population; Series; Systems Biology; Universities; Visit; Work; age related; biomedical informatics; environmental stressor; epigenome; epigenomics; graduate student; human disease; next generation; programs; public health relevance; symposium

DESCRIPTION (provided by applicant): Our objective is to establish a highly interactive and dynamic group of investigators whose research focuses on understanding the functional role of epigenetic changes in human disease etiology and progression. We have proposed five new research projects all led by junior investigators, that will use molecular, biochemical, and computational biology approaches to study epigenetic regulation in different disease models. We will help define the role that environmental stressors play in disruption of the epigenome, and propose cutting edge, critical research in trans-generational models to understand how changes in the epigenomic may be linked to complex inheritance patterns and familial risk factors for high incidence diseases. These goals will be accomplished utilizing an integrative, systems biology approach to link epigenomic platforms such as global methylation arrays with next-generation RNA-sequencing and Chip-sequencing. To enhance the program further, we have included a translational component as a key facet of this COBRE, which is consistent with our global, strategic mission to address the needs of North Dakota's aging, largely rural population. Because epigenetic changes are potentially reversible, we believe that this research could lead to new treatment paradigms for devastating diseases such as cancer, drug addiction, and cardiovascular disease. The rationale for this center is that each individual brings unique expertise and key directions that together can help elucidate the role of epigenetic changes in various disease models. This center will nurture a focused group of investigators, and successful completion of our specific aims will result in the establishment of a collaborative and sustainable Center of Excellence in the Epigenomics of Development and Disease capable of attracting the brightest and most talented faculty, graduate students and postdoctoral fellows to conduct world class research in the burgeoning field of epigenetics. UND is fully committed to ensuring the growth and sustainability of this group even after the COBRE grant ends.

描述（由申请人提供）：我们的目标是建立一个高度互动和动态的研究人员，其研究重点是理解表观遗传变化在人类疾病病因学和进展中的功能作用。我们提出了五个由初级研究人员领导的新研究项目，这些项目将使用分子，生化和计算生物学方法来研究不同疾病模型的表观遗传调节。我们将有助于定义环境压力源在破坏表观基因组中起作用的作用，并提出了跨代模型中的尖端研究，以了解表观基因组学的变化如何与复杂的遗传模式和高发病率疾病的家族风险因素有关。这些目标将利用一种集成的系统生物学方法来实现，以将表观基因组平台（例如全球甲基化阵列）与下一代RNA序列和芯片序列联系起来。为了进一步增强该计划，我们将翻译成分作为该鞋底的关键方面，这与我们全球战略使命是一致的，该使命是满足北达科他州老龄化（大部分农村人口）需求的全球战略使命。由于表观遗传变化可能是可逆的，因此我们认为这项研究可能会导致癌症，吸毒和心血管疾病等毁灭性疾病的新治疗范例。该中心的理由是，每个人都带来了独特的专业知识和关键方向，共同有助于阐明表观遗传变化在各种疾病模型中的作用。该中心将培养一群重点的研究人员，并成功完成我们的具体目标将导致建立一个协作且可持续的卓越中心，以发展能够吸引最聪明，最有才华的教师，研究生和博士后学生的发展和疾病的表观基因组学和疾病。 UND也完全致力于确保该集团的增长和可持续性，即使在鞋垫赠款结束之后。