Center of Biomedical Research Excellence, Epigenomics of Development and Disease

生物医学卓越研究中心，发育与疾病表观基因组学

• 批准号: 10448459
• 负责人: ROXANNE A VAUGHAN
• 金额: $ 200.37万
• 依托单位: UNIVERSITY OF NORTH DAKOTA
• 依托单位国家: 美国
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-09-10 至 2024-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10448459
• 关键词: Accountability; Area; Award; Bioinformatics; Centers of Research Excellence; Clinical; Communities; Competence; DNA Sequence; Data; Development; Disease; Epigenetic Process; Extramural Activities; Faculty; Faculty Recruitment; Fee-for-Service Plans; Financial Support; Foundations; Funding; Funding Opportunities; Gene Expression; Genome; Genomics; Goals; Grant; Growth; Health; Heritability; Human; Individual; Infrastructure; Institution; International; Journals; Mentors; Molecular; Nature; North Dakota; Oral; Paper; Pathologic; Phase; Postdoctoral Fellow; Program Development; Public Health; Publishing; Research; Research Personnel; Research Project Grants; Resolution; Role; Scientist; Students; Sum; Talents; Teacher Professional Development; Technology; Training; Training and Education; Universities; Vision; Writing; epigenomics; faculty support; human disease; interest; meetings; member; next generation; next generation sequencing; posters; pre-clinical; programs; recruit; success; symposium; working group

UNIVERSITY OF NORTH DAKOTA EPIGENOMICS OF DEVELOPMENT AND DISEASE OVERALL PROJECT SUMMARY The goal of this COBRE II application is to expand and enhance research into epigenetic mechanisms underlying development and disease at the University of North Dakota by providing ongoing support to the Epigenetics Working Group (EWG). In COBRE I the EWG made significant progress towards development of an epigenetics/epigenomics program through support of individual projects; recruitment of epigenetics experts to our group and supporting faculty development through mentoring programs. We established a comprehensive Genomics Core to meet the needs of the epigenetics community and provided technical and financial support that increased the number of researchers in our community utilizing epigenetic approaches. In Phase I our COBRE Investigators made important discoveries that resulted in 253 papers published in high impact journals, 66 poster and oral presentations by Project Leaders at invited seminars or scientific meetings, and the awarding of more than $10.8 million in external funding primarily from R01, R21, and NSF grants. Here we seek to maintain this momentum through continuation and expansion of these programs via the following strategies: We will recruit faculty with interests and expertise that increase the size of our group and extend our competencies into mechanistic and translational areas; We will enhance the offerings of the Genomics Core to further increase the ability of our group to perform high-quality research; We will enhance the ability of our investigators to transition to independent funding through support of individual projects and scientific and faculty development mentoring programs. Our long-term goal is to transition the EWG into a sustainable scientific center dedicated to understanding molecular mechanisms of developmental and pathological disorders that will attract top talent, train the next generation of scientists, and become a regional hub for cutting edge epigenetics research. ! ! !

北达科他大学 发育和疾病的表观基因组学 全面的 项目摘要 该毛线II应用的目的是扩展和增强研究对表观遗传学 北达科他大学的发展和疾病的机制 为表观遗传学工作组（EWG）提供持续的支持。在Cobre I中 在发展表观遗传学/表观基因组学计划方面取得了重大进展 通过支持各个项目；向我们小组招募表观遗传学专家 通过指导计划支持教师发展。我们建立了一个全面的 基因组学核心满足表观遗传学界​​的需求，并提供技术和 利用表观遗传学的研究人员数量增加了我们社区中的研究人员的数量 方法。在第一阶段，我们的毛茸茸的调查人员做出了重要发现 253篇论文发表在《高影响期刊》上 受邀研讨会或科学会议的领导者，授予超过1,080万美元 外部资金主要来自R01，R21和NSF赠款。 在这里，我们试图通过继续和扩展这些来维持这种势头 通过以下策略的计划：我们将以利益和专业知识招募教​​师 增加我们小组的规模，并将能力扩展到机械和翻译 区域；我们将增强基因组学核心的产品，以进一步提高我们的能力 小组进行高质量的研究；我们将增强调查人员的能力 通过支持单个项目以及科学和教师的过渡到独立资金 开发指导计划。我们的长期目标是将EWG转变为 可持续科学中心致力于理解分子机制 发育和病理障碍将吸引顶尖人才，训练下一代 科学家，成为尖端表观遗传学研究的区域枢纽。 呢 呢 呢