Cholinergic and noradrenergic inputs to early olfactory processing

早期嗅觉处理的胆碱能和去甲肾上腺素能输入

• 批准号: 7770914
• 负责人: CHRISTIANE LINSTER
• 金额: $ 15.9万
• 依托单位: CORNELL UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-08-01 至 2011-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7770914
• 关键词: Acetylcholine; Affect; Afferent Neurons; Animals; Area; Asses; Attention; Behavioral; Behavioral Assay; Brain Stem; Cholinergic Receptors; Collaborations; DDX26 gene; Data; Detection; Diagonal Band of Broca; Diffusion; Discrimination; Discrimination Learning; Dopamine; Drug usage; Electrodes; Emotional; Fire - disasters; Grant; Half-Life; Impairment; Infusion procedures; Institution; Investigation; Lead; Learning; Lesion; Light; Limb structure; Maintenance; Measurable; Mediating; Memory; Modeling; Mus; Muscarinics; Neuromodulator; Neurons; Neurosciences; Nicotinic Receptors; Noise; Norepinephrine; Odors; Pattern; Perception; Pharmaceutical Preparations; Phase; Process; Rattus; Regulation; Rewards; Rodent; Role; Rosa; Sensory; Sensory Process; Serotonin; Shapes; Short-Term Memory; Signal Transduction; Stimulus; Structure; System; Techniques; Testing; Time; Training; Work; basal forebrain; base; behavioral pharmacology; cholinergic; cholinergic neuron; experience; follow-up; improved; locus ceruleus structure; neuroregulation; noradrenergic; novel; olfactory bulb; olfactory stimulus; piriform cortex; public health relevance; receptor; relating to nervous system; research study; response; sensory cortex

Description (provided by applicant): Neuromodulatory inputs to early sensory processing areas, such as acetylcholine, noradrenaline, serotonin and dopamine, are thought to support a number of functions relating attention, alert, reward and emotional states. Neuromodulatory inputs regulate the states of sensory and cortical networks, change local computations and affect the dynamics of these networks. Among early sensory processing areas, because of the strong correlations between sensory inputs, neural activity and perception, the transformation of sensory perception by neuromodulatory inputs is directly measurable in the olfactory bulb (OB) of rodents. A crucial function of the OB is to integrate afferent information from the sensory neurons in concert with descending cortical and neuromodulatory inputs from central structures such as the piriform cortex, basal forebrain and brain stem. Accumulating evidence indicates that olfactory discrimination is at least partially mediated by processes in the OB and that cholinergic as well as noradrenergic centrifugal inputs to the OB modulate perceptual discrimination. The present proposal uses multi-electrode recordings in behaving rats to further elucidate the contribution of cholinergic and noradrenergic inputs to the OB for olfactory perception and learning. Neural activity in the locus coeruleus and horizontal limb of the diagonal band of Boca will be recorded in rats performing one of three different olfactory tasks. We hypothesize that cholinergic inputs will be involved in shaping olfactory representations and comparisons of stimuli to those previously encoded whereas noradrenergic inputs will be involved in the formation and maintenance of short memoires as well as in the regulation of signal-to noise ratio. PUBLIC HEALTH RELEVANCE: Neuromodulatory inputs to primary sensory cortex modulate sensory perception and learning. Disruption of these processes leads to impairments in the detection, discrimination and learning of sensory inputs. The proposed work will have significance for our understanding of how neuromodulatory inputs are involved in sensory processing and memory formation.

描述（由申请人提供）：乙酰胆碱，去甲肾上腺素，5-羟色胺和多巴胺等早期感觉处理区域的神经调节输入被认为支持许多功能，这些功能与注意力，警觉，奖励，奖励和情绪状态有关。神经调节输入调节感觉和皮质网络状态，更改局部计算并影响这些网络的动态。在早期的感觉处理区域中，由于感觉输入，神经活动和感知之间存在很强的相关性，因此在啮齿动物的嗅球（OB）中可以直接测量神经调节输入的感觉感知的转化。 OB的关键功能是将来自感觉神经元的传入信息与中心结构（例如梨状皮层，基础前脑和脑茎）的降层皮质和神经调节输入共同整合。积累的证据表明，嗅觉歧视至少是由OB中的过程和胆碱能以及去甲肾上腺素能离心的输入的部分介导的，以调节OB调节感知歧视。本提案在行为大鼠中使用多电极记录来进一步阐明胆碱能和去甲肾上腺素能量对OB的贡献，以实现嗅觉感知和学习。 BOCA的对角线带的基因座和水平肢体中的神经活动将记录在执行三种不同嗅觉任务之一的大鼠中。我们假设胆碱能输入将参与将嗅觉表示和刺激的比较与先前编码的刺激的比较，而甲肾上腺素能输入将参与简短回忆录的形成和维持，以及信号噪声比的调节。公共卫生相关性：主要感觉皮层的神经调节输入调节感觉知觉和学习。这些过程的破坏会导致在检测，歧视和学习感觉输入方面的损害。拟议的工作将对我们了解神经调节输入如何参与感觉处理和记忆形成的意义。