INFORMATION THEORY OF THE ANTERIOR CINGULATE CORTEX

前扣带皮层的信息论

• 批准号: 7953735
• 负责人: JIN FAN
• 金额: $ 0.24万
• 依托单位: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-03-01 至 2009-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7953735
• 关键词: Accounting; Anterior; Behavioral; Brain Mapping; Clinical Research; Cognitive; Computer Retrieval of Information on Scientific Projects Database; Conflict (Psychology); Employee Strikes; Funding; Grant; Human; Individual Differences; Information Theory; Institution; Lesion; Modeling; Pathway interactions; Patients; Performance; Play; Process; Reaction Time; Relative (related person); Research; Research Personnel; Resolution; Resources; Role; Source; Speed; Structure; United States National Institutes of Health; cingulate cortex; cognitive control; indexing; information processing; neuroimaging; neuromechanism; relating to nervous system; response; theories

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. 9/17/2008 Our ability to rapidly process information and generate responses depends greatly on cognitive control, whose neural mechanisms have been extensively studied with recent advances in human brain mapping. Current theories of cognitive control have focused on the role of the anterior cingulate cortex (ACC) in conflict detection/resolution and response selection. However, these theories cannot account for the striking finding that patients with ACC lesions do not show deficits in conflict detection/resolution but rather overall slowness of response. Meanwhile, from behavioral and functional neuroimaging studies we have observed that (i) there is a robust correlation between overall reaction time (RT), the conflict effect, and ACC activation, and that (ii) the ACC is commonly activated in all cognitive task states compared to baseline state. The emerging evidence suggest that the ACC is a major determinant of information processing rate and response speed, as indexed by overall RT. Building on our and others' previous theoretical perspectives and these observations, we propose an information theory model of the ACC in which the ACC serves as a fast relay and integrative interface with dynamic interconnections between cortical and subcortical structures and plays a pivotal role in central cognitive control of rapid information processing and response, beyond traditional theories of conflict detection/resolution. In this project, we will assess functional activation and integration of the ACC and model its neural dynamics during rapid information processing and response in order to establish network-function relationships. Specifically, we hypothesize that: (1) the activity of the ACC and the dynamic functional/effective connectivity among the ACC and associated pathways are critically involved in these processes and determine the relative efficiency of these processes; and (2) the functional activity and dynamic connectivity of the ACC predict a significant proportion of individual differences in behavioral performance related to these processes.

该副本是利用众多研究子项目之一 由NIH/NCRR资助的中心赠款提供的资源。子弹和 调查员（PI）可能已经从其他NIH来源获得了主要资金， 因此可以在其他清晰的条目中代表。列出的机构是 对于中心，这不一定是调查员的机构。 2008年9月17日 我们快速处理信息和产生反应的能力在很大程度上取决于认知控制，其神经机制已被广泛研究，并在人脑映射方面的最新进展。当前的认知控制理论集中在前扣带回皮层（ACC）在冲突检测/解决和响应选择中的作用。但是，这些理论无法解释出惊人的发现，即ACC病变患者没有在冲突检测/解决方案中显示出缺陷，而是总体上反应缓慢。 同时，从行为和功能性神经影像学研究中，我们观察到（i）（i）在总体反应时间（RT），冲突效应和ACC激活之间存在牢固的相关性，并且（ii）与基线状态相比，在所有认知任务状态下，ACC通常在所有认知任务状态中都被激活。新兴的证据表明，ACC是信息处理速度和响应速度的主要决定因素，如总RT所示。在我们和其他人以前的理论观点和这些观察的基础上，我们提出了ACC的信息理论模型，在该模型中，ACC充当了快速的继电器和综合接口，具有皮质和副皮层结构之间的动态互连，并在快速信息处理和反应中的中央认知控制中起着关键的作用，超出了传统的信息处理和响应的中心认知控制，而不是传统的依据。 在该项目中，我们将评估ACC的功能激活和集成，并在快速信息处理和响应过程中对其神经动态进行建模，以建立网络功能关系。 具体来说，我们假设： （1）ACC和ACC和相关途径之间的活性和动态功能/有效连通性与这些过程非常重要，并确定这些过程的相对效率；和 （2）ACC的功能活性和动态连通性预测了与这些过程相关的行为绩效中个体差异的很大比例。