Uncertainty, Cognitive Control, and the Brain

不确定性、认知控制和大脑

基本信息

批准号：
8660085
负责人：
JIN FAN
金额：
$ 34.88万
依托单位：
QUEENS COLLEGE
依托单位国家：
美国
项目类别：
财政年份：
2012
资助国家：
美国
起止时间：
2012-06-01 至 2017-04-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8660085
关键词：
Accounting Address Adopted Adult Algorithms Anterior Area Auditory Autistic Disorder Behavioral Biological Models Brain Communication Conflict (Psychology)Conscious Data Detection Development Disease Entropy Event Functional Magnetic Resonance Imaging Goals Information Theory Investigation Knowledge Measures Mental disorders Methods Middle frontal gyrus structure Modality Modeling Monitor Neurobiology Neurons Outcome Parietal Lobe Performance Play Population Process Psyche structure Psychopathology Reaction Time Research Resolution Role Schizophrenia Series Signal Transduction Specificity Stimulus Structure System Techniques Testing Time Translational Research Uncertainty Variant Visual base cingulate cortex cognitive control cognitive neuroscience design frontal eye fields frontal lobe information processing intraparietal sulcus neural circuit neuroimaging neuromechanism novel operation relating to nervous system research study response theories therapy development volunteer

项目摘要

DESCRIPTION (provided by applicant): The neural correlates of cognitive control have been studied extensively using various neuroimaging techniques. Certain theoretical accounts posit a major role of the anterior cingulate cortex (ACC) in networks hypothesized to underlie conflict monitoring and resolution. However, the scope of these accounts has proven limited. We argue that conflict is only a special case of uncertainty that can be quantified as information entropy, based on an information theory framework. In conjunction with the existence of a robust relationship between functional activation of regions in a frontoparietocingulate system and reaction time performance across various behavioral tasks requiring cognitive control, as well as observation of a special class of neurons found in the ACC that are well suited for rapid and long distance integration of information among distributed regions involved in cognitive control, we propose a frontoparietocingulate system model of cognitive control in which the ACC plays a major role in signaling uncertainty. In order to test this model, we have designed a series of experiments with various information theoretic measures and propose to examine functional activity and connectivity of the frontoparietocingulate system as a function of information entropy using functional magnetic resonance imaging. This study not only challenges the current theories of cognitive control, but also has a wide ranging impact within the field of cognitive neuroscience as well as studies on the disruption of cognitive control in a variety of major psychiatric disorders.

描述（由申请人提供）：使用各种神经影像技术对认知控制的神经相关性进行了广泛的研究。某些理论上的说法在被认为是冲突监测和解决方案的基础的网络中提出了前扣带回皮层（ACC）的主要作用。但是，这些帐户的范围已被证明有限。我们认为，基于信息理论框架，冲突只是一个不确定性的特殊情况，可以被量化为信息熵。结合结合在额产系统中的区域功能激活之间存在牢固的关系信号不确定性中的作用。为了测试该模型，我们设计了一系列具有各种信息理论措施的实验，并提议检查额产系统的功能活动和连通性作为信息熵的函数使用功能磁共振成像。这项研究不仅挑战了当前的认知控制理论，而且在认知神经科学领域以及对多种主要精神疾病中认知控制的破坏的研究都具有广泛的影响。