IMPROVED CINE MRI BY DIRECT-INVERSION RECONSTRUCTION

通过直接反转重建改进电影 MRI

• 批准号: 7385983
• 负责人: MARIJN EDUARD BRUMMER
• 金额: $ 37.14万
• 依托单位: EMORY UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-03-01 至 2010-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7385983
• 关键词: Acceleration; Affect; Anatomy; Arts; Binding; Biological Preservation; Blood Flow Velocity; Breathing; Cardiac; Cardiovascular Diseases; Characteristics; Cine Magnetic Resonance Imaging; Class; Clinical; Compatible; Coronary artery; Data; Development; Diagnostic; Equipment; Evaluation; Goals; Guidelines; Heart; Heart Diseases; Image; Imaging Phantoms; Individual; Investigation; Knowledge; Light; Magnetic Resonance Imaging; Maps; Measurement; Methods; Metric; Modeling; Monitor; Morphologic artifacts; Motion; Noise; Numbers; Pathology; Patients; Phase; Physicians; Process; Pulsatile Flow; Quantitative Evaluations; Range; Reproducibility; Research; Research Personnel; Resolution; Respiration; Sampling; Scanning; Signal Transduction; Simulate; Speed; Standards of Weights and Measures; Structure; Symptoms; System; Taxes; Techniques; Technology; Technology Transfer; Testing; Time; Vendor; base; data acquisition; design; desire; expiration; healthy volunteer; heart visualization; image reconstruction; improved; innovation; movie; novel; programs; prospective; prototype; radiofrequency; reconstruction; research study; respiratory; statistics; success; tool; volunteer

Acquisition speed remains a critical issue in cine magnetic resonance imaging (MRI). Structural and functional cardiac imaging, and increasingly also coronary artery and flow imaging, are becoming ever-more important tools in evaluation of a wide range of cardiovascular diseases. All of these scans often involve anatomy that is subject to both cardiac and respiratory motion. Multi-phase ECG-gated imaging is nowadays routinely performedin breath-hold mode, but both the duration and number of breath-hold acquisitions that can be tolerated by the patient are dominant limiting factorsfor image quality and resolution. These limitations are aggravated by the particular symptoms of many cardiac diseases. Faster MRI data acquisition is being pursued in multiple ways: improved gradient hardware allows faster spatial encoding; phased-array radiofrequency coils offer increased signal-to-noise ratio (SNR); new steady- state free precession acquisition techniques contribute improvements on both these fronts; other innovations, like partial-Fourier imaging, parallel imaging, or reduced field of view (rFOV) methods explore further improvements in imaging speed, often by trading some SNR, by exploiting various types of prior knowledge in the imaging model. Combined use of technologies that improve SNR or speed keeps pushing the limits of clinically feasible applications of cine imaging. However, not all techniques are always compatible, and the gains from all individual techniques are bounded, so the development of additional technologies in this realm is still desired and highly relevant. This proposal will investigate development and evaluation of a novel rFOV technique that promises to offer important advantages over comparable methods in terms of spatial and temporal resolution. The project builds on encouraging preliminary results from a retrospective implementation, using reduced subsets from conventionally acquired MRI data to obtain full-resolution cine reconstructions. Development is proposed of a full prospective implementation of the acquisition method on clinical equipment. Optimization will be investigated with respect to SNR, artifacts, and numerical efficiency. Qualitative and quantitative evaluations will be performed of image quality and flow calculations using the method. Finally, feasibility will be investigated of combining this method and parallel imaging methods.

在Cine磁共振成像（MRI）中，采集速度仍然是一个关键问题。结构和 功能性心脏成像，越来越多的冠状动脉和流成像变得越来越多 评估多种心血管疾病的重要工具。所有这些扫描通常都涉及 解剖学受心脏和呼吸运动的影响。如今，多相ECG门控成像 经常执行呼吸模式，但持续时间和呼吸次数的收购数量 患者可以容忍的是图像质量和分辨率的主要限制因素。这些 许多心脏病的特殊症状加剧了局限性。 更快的MRI数据获取正在以多种方式进行：改进的梯度硬件允许更快 空间编码；分阶段阵列射频线圈提供了增加信号噪声比（SNR）；新的稳定 - 国家自由进步采集技术在这两个方面都有改进；其他 创新，例如局部倍数成像，并行成像或降低的视野（RFOV）方法探索 通常通过利用各种类型的先验来进一步改善成像速度，通常通过交易一些SNR 成像模型中的知识。改善SNR或速度的技术的结合使用不断推动 Cine成像的临床可行应用的极限。但是，并非所有技术总是 兼容，所有个人技术的收益都是有限的，因此开发了其他 该领域中的技术仍然是必需的，而且高度相关。 该建议将调查一种新型RFOV技术的开发和评估，该技术有望 就空间和时间分辨率而言，比可比方法具有重要的优势。项目 以回顾性实施为基于鼓励初步结果，使用减少的子集 常规获取MRI数据以获得完整的CINE重建。提出了一个发展 对临床设备的采集方法的全面实施。优化将是 研究了SNR，工件和数值效率。定性和定量评估 将使用该方法对图像质量和流量计算进行。最后，可行性将是 研究了这种方法和并行成像方法。