INTERACTIVE 4D VISUALIZATION OF CONGENITAL HEART DISEASE

先天性心脏病的交互式 4D 可视化

• 批准号: 2897390
• 负责人: MARIJN EDUARD BRUMMER
• 金额: $ 10.9万
• 依托单位: EMORY UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1997
• 资助国家: 美国
• 起止时间: 1997-05-01 至 2002-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2897390
• 关键词: bioimaging /biomedical imaging; cardiovascular imaging /visualization; child (0-11); clinical research; computer assisted diagnosis; computer program /software; computer system design /evaluation; congenital cardiovascular disorder; congenital heart disorder; diagnosis design /evaluation; functional magnetic resonance imaging; heart imaging /visualization /scanning; human subject; image enhancement; infant human (0-1 year); interactive multimedia

DESCRIPTION (Taken from application abstract): Development and clinical testing of a new family of software display techniques for cardiovascular magnetic resonance imaging (MRI) data are proposed. These efforts are anticipated to enhance the diagnostic process and facilitate currently challenging decisions on therapy and patient management of children with severe congenital heart disease. In particular, assessment of hypoplastic left and right heart syndromes and univentricular heart require improved visualization and function quantification tools for evaluation and monitoring of severity and functional status. The initial design of the system is largely completed. Design features of the software system are footed on recent improvements in widely available 3-D rendering hardware and on observations made during 11 years of clinical experience with cardiac MRI at the investigation site During the first year of the project a clinically usable prototype can be delivered for testing and user feedback, including a highly streamlined image data pipeline, sophisticated contemporary user interface, and other features essential for extensive clinical evaluation. The proposed dynamic 3-D display technique combines a maximum of anatomical information available in a multi-slice ECG-triggered cine-MRI scan of the heart, by displaying all slice images simultaneously in correct 3-D geometric perspective in dynamic fashion (a cyclic movie of the beating heart). A user can manipulate in real-time the displayed slice objects to improve visualization of regional anatomy, generate reformatted views along cutting planes on-the-fly, and annotate the display for other observers by highlighting 3-D regions of interest. The proposed effort includes (1) development of first prototype using extensive preexisting in-house developed software libraries, (2) clinical evaluation of the technique from the second year of the project onwards, (3) implementation of enhancements including quantitation and display of essential cardiac function parameters including hemodynamic data and follow-up on user feedback, and adding limited DICOM I/O functionality.

描述（摘自申请摘要）：开发和临床 测试心血管软件显示技术的新系列 提出了磁共振成像（MRI）数据。 这些努力是 预计将加强诊断过程并促进目前 对患有该病的儿童的治疗和患者管理做出具有挑战性的决定 严重的先天性心脏病。 特别是发育不良的评估 左右心综合症和单心室心脏需要改善 用于评估和评估的可视化和功能量化工具 监测严重程度和功能状态。 系统的初步设计已基本完成。 设计特点 该软件系统基于广泛可用的最新改进 3-D 渲染硬件和 11 年临床观察结果 第一年在调查现场进行心脏 MRI 的经验 该项目可以交付临床可用的原型进行测试 和用户反馈，包括高度简化的图像数据管道， 复杂的现代用户界面，以及其他必不可少的功能 广泛的临床评估。 所提出的动态 3D 显示技术结合了最大程度的解剖学特征 多切片心电图触发的电影 MRI 扫描中提供的信息 心脏，通过以正确的 3D 同时显示所有切片图像 动态时尚中的几何透视（殴打的循环电影 心）。 用户可以实时操作显示的切片对象 改善区域解剖的可视化，生成重新格式化的视图 即时切割平面，并通过以下方式为其他观察者注释显示 突出显示 3D 感兴趣区域。 拟议的工作包括 (1) 使用以下方法开发第一个原型 广泛的现有内部开发软件库，(2) 临床 从项目第二年开始对技术进行评估，(3) 实施增强功能，包括定量和显示 重要的心脏功能参数，包括血流动力学数据和 跟进用户反馈，并添加有限的 DICOM I/O 功能。