IMPROVED CINE MRI BY DIRECT-INVERSION RECONSTRUCTION

通过直接反转重建改进电影 MRI

• 批准号: 7190484
• 负责人: MARIJN EDUARD BRUMMER
• 金额: $ 36.61万
• 依托单位: EMORY UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-03-01 至 2010-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7190484
• 关键词: Acceleration; Affect; Anatomy; Arts; Binding; Biological Preservation; Blood Flow Velocity; Breathing; Cardiac; Cardiovascular Diseases; Characteristics; Cine Magnetic Resonance Imaging; Class; Clinical; Compatible; Coronary artery; Data; Development; Diagnostic; Equipment; Evaluation; Goals; Guidelines; Heart; Heart Diseases; Image; Imaging Phantoms; Individual; Investigation; Knowledge; Light; Magnetic Resonance Imaging; Maps; Measurement; Methods; Metric; Modeling; Monitor; Morphologic artifacts; Motion; Noise; Numbers; Pathology; Patients; Phase; Physicians; Process; Pulsatile Flow; Quantitative Evaluations; Range; Reproducibility; Research; Research Personnel; Resolution; Respiration; Sampling; Scanning; Signal Transduction; Simulate; Speed; Standards of Weights and Measures; Structure; Symptoms; System; Taxes; Techniques; Technology; Technology Transfer; Testing; Time; Vendor; base; data acquisition; design; desire; expiration; healthy volunteer; heart visualization; image reconstruction; improved; innovation; movie; novel; programs; prospective; prototype; radiofrequency; reconstruction; research study; respiratory; statistics; success; tool; volunteer

DESCRIPTION (provided by applicant): Acquisition speed remains a critical issue in cine magnetic resonance imaging (MRI). Structural and functional cardiac imaging, and increasingly also coronary artery and flow imaging, are becoming ever-more important tools in evaluation of a wide range of cardiovascular diseases. All of these scans often involve anatomy that is subject to both cardiac and respiratory motion. Multi-phase ECG-gated imaging is nowadays routinely performed in breath-hold mode, but both the duration and number of breath-hold acquisitions that can be tolerated by the patient are dominant limiting factors for image quality and resolution. These limitations are aggravated by the particular symptoms of many cardiac diseases. Faster MRI data acquisition is being pursued in multiple ways: improved gradient hardware allows faster spatial encoding; phased-array radiofrequency coils offer increased signal-to-noise ratio (SNR); new steady- state free precession acquisition techniques contribute improvements on both these fronts; other innovations, like partial-Fourier imaging, parallel imaging, or reduced field of view (rFOV) methods explore further improvements in imaging speed, often by trading some SNR, by exploiting various types of prior knowledge in the imaging model. Combined use of technologies that improve SNR or speed keeps pushing the limits of clinically feasible applications of cine imaging. However, not all techniques are always compatible, and the gains from all individual techniques are bounded, so the development of additional technologies in this realm is still desired and highly relevant. This proposal will investigate development and evaluation of a novel rFOV technique that promises to offer important advantages over comparable methods in terms of spatial and temporal resolution. The project builds on encouraging preliminary results from a retrospective implementation, using reduced subsets from conventionally acquired MRI data to obtain full-resolution cine reconstructions. Development is proposed of a full prospective implementation of the acquisition method on clinical equipment. Optimization will be investigated with respect to SNR, artifacts, and numerical efficiency. Qualitative and quantitative evaluations will be performed of image quality and flow calculations using the method. Finally, feasibility will be investigated of combining this method and parallel imaging methods.

描述（由申请人提供）：采集速度仍然是Cine磁共振成像（MRI）的关键问题。结构和功能性心脏成像，以及越来越多的冠状动脉和流动成像，在评估广泛的心血管疾病方面已成为越来越重要的工具。所有这些扫描通常涉及心脏和呼吸运动的解剖结构。如今，多相ECG门控成像是在呼吸持续模式下常规执行的，但是患者可以耐受的呼吸持续收购的持续时间和数量都是图像质量和分辨率的主要限制因素。许多心脏病的特殊症状加剧了这些局限性。更快的MRI数据获取正在通过多种方式进行：改进的梯度硬件可以更快地进行空间编码；分阶段阵列射频线圈提供了增加信号噪声比（SNR）；新的稳定稳定预动力采集技术在这两个方面都有贡献。其他创新，例如部分倍数成像，并行成像或降低的视野（RFOV）方法，通常通过在成像模型中利用各种类型的先验知识来探索成像速度的进一步改进。改善SNR或速度的技术的结合使用不断推动Cine成像的临床可行应用的限制。但是，并非所有技术总是兼容，并且所有单个技术的收益都是有限的，因此在该领域中的其他技术的开发仍然是期望且高度相关的。该建议将研究一种新型RFOV技术的开发和评估，该技术有望在空间和时间分辨率方面具有重要的优势。该项目以回顾性实施为鼓励的初步结果建立，使用常规获取的MRI数据减少的子集以获得完整的CINE重建。提出的开发是针对临床设备的收购方法的全面实施。将对SNR，工件和数值效率进行优化。将使用该方法对图像质量和流量计算进行定性和定量评估。最后，将研究可行性，以结合此方法和并行成像方法。