IMPROVED CINE MRI BY DIRECT-INVERSION RECONSTRUCTION

通过直接反转重建改进电影 MRI

• 批准号: 7190484
• 负责人: MARIJN EDUARD BRUMMER
• 金额: $ 36.61万
• 依托单位: EMORY UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-03-01 至 2010-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7190484
• 关键词: Acceleration; Affect; Anatomy; Arts; Binding; Biological Preservation; Blood Flow Velocity; Breathing; Cardiac; Cardiovascular Diseases; Characteristics; Cine Magnetic Resonance Imaging; Class; Clinical; Compatible; Coronary artery; Data; Development; Diagnostic; Equipment; Evaluation; Goals; Guidelines; Heart; Heart Diseases; Image; Imaging Phantoms; Individual; Investigation; Knowledge; Light; Magnetic Resonance Imaging; Maps; Measurement; Methods; Metric; Modeling; Monitor; Morphologic artifacts; Motion; Noise; Numbers; Pathology; Patients; Phase; Physicians; Process; Pulsatile Flow; Quantitative Evaluations; Range; Reproducibility; Research; Research Personnel; Resolution; Respiration; Sampling; Scanning; Signal Transduction; Simulate; Speed; Standards of Weights and Measures; Structure; Symptoms; System; Taxes; Techniques; Technology; Technology Transfer; Testing; Time; Vendor; base; data acquisition; design; desire; expiration; healthy volunteer; heart visualization; image reconstruction; improved; innovation; movie; novel; programs; prospective; prototype; radiofrequency; reconstruction; research study; respiratory; statistics; success; tool; volunteer

DESCRIPTION (provided by applicant): Acquisition speed remains a critical issue in cine magnetic resonance imaging (MRI). Structural and functional cardiac imaging, and increasingly also coronary artery and flow imaging, are becoming ever-more important tools in evaluation of a wide range of cardiovascular diseases. All of these scans often involve anatomy that is subject to both cardiac and respiratory motion. Multi-phase ECG-gated imaging is nowadays routinely performed in breath-hold mode, but both the duration and number of breath-hold acquisitions that can be tolerated by the patient are dominant limiting factors for image quality and resolution. These limitations are aggravated by the particular symptoms of many cardiac diseases. Faster MRI data acquisition is being pursued in multiple ways: improved gradient hardware allows faster spatial encoding; phased-array radiofrequency coils offer increased signal-to-noise ratio (SNR); new steady- state free precession acquisition techniques contribute improvements on both these fronts; other innovations, like partial-Fourier imaging, parallel imaging, or reduced field of view (rFOV) methods explore further improvements in imaging speed, often by trading some SNR, by exploiting various types of prior knowledge in the imaging model. Combined use of technologies that improve SNR or speed keeps pushing the limits of clinically feasible applications of cine imaging. However, not all techniques are always compatible, and the gains from all individual techniques are bounded, so the development of additional technologies in this realm is still desired and highly relevant. This proposal will investigate development and evaluation of a novel rFOV technique that promises to offer important advantages over comparable methods in terms of spatial and temporal resolution. The project builds on encouraging preliminary results from a retrospective implementation, using reduced subsets from conventionally acquired MRI data to obtain full-resolution cine reconstructions. Development is proposed of a full prospective implementation of the acquisition method on clinical equipment. Optimization will be investigated with respect to SNR, artifacts, and numerical efficiency. Qualitative and quantitative evaluations will be performed of image quality and flow calculations using the method. Finally, feasibility will be investigated of combining this method and parallel imaging methods.

描述（由申请人提供）：采集速度仍然是电影磁共振成像（MRI）中的一个关键问题。结构和功能心脏成像，以及越来越多的冠状动脉和血流成像，正在成为评估各种心血管疾病的越来越重要的工具。所有这些扫描通常涉及受心脏和呼吸运动影响的解剖结构。如今，多相心电图门控成像通常在屏气模式下进行，但患者可以忍受的屏气采集的持续时间和次数是图像质量和分辨率的主要限制因素。许多心脏病的特殊症状加剧了这些限制。人们正在通过多种方式追求更快的 MRI 数据采集：改进的梯度硬件允许更快的空间编码；相控阵射频线圈可提高信噪比 (SNR)；新的稳态自由进动采集技术在这两个方面都做出了贡献；其他创新，如部分傅里叶成像、并行成像或缩小视场 (rFOV) 方法，通常通过利用成像模型中的各种类型的先验知识，通过牺牲一些信噪比来探索成像速度的进一步提高。提高信噪比或速度的技术的组合使用不断突破电影成像临床可行应用的极限。然而，并非所有技术总是兼容的，并且所有单独技术的收益都是有限的，因此该领域的其他技术的开发仍然是可取的并且具有高度相关性。该提案将研究一种新型 rFOV 技术的开发和评估，该技术有望在空间和时间分辨率方面比同类方法提供重要优势。该项目建立在回顾性实施的令人鼓舞的初步结果的基础上，使用传统采集的 MRI 数据的减少子集来获得全分辨率电影重建。建议在临床设备上全面前瞻性地实施采集方法。我们将研究信噪比、伪影和数值效率方面的优化。将使用该方法对图像质量和流量计算进行定性和定量评估。最后，研究将该方法与并行成像方法相结合的可行性。