Special Mouse Strains Resource

特殊小鼠品系资源

基本信息

批准号：
10645429
负责人：
Cathleen M Lutz
金额：
$ 41.01万
依托单位：
JACKSON LABORATORY
依托单位国家：
美国
项目类别：
财政年份：
2022
资助国家：
美国
起止时间：
2022-07-01 至 2026-01-31
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10645429
关键词：
Address Animals Archives Biological Biomedical Research Breeding Caring Cells Collaborations Collection Communities Complex Consomic Strain DNA sequencing Data Derivation procedure Development Disease Dissection Ensure Environmental Risk Factor Epigenetic Process Epistatic Gene Faculty Foundations Funding Future Genes Genetic Genetic Drift Genetic Engineering Genetic Epistasis Genetic Heterogeneity Genetic Research Genetic Variation Genetic study Genome Genotype Geography Goals Health Health Status Heritability Human Human Biology Human Genetics Inbred Strain Inbreeding Infrastructure Institution Investments Laboratory mice Leadership Legal Medical Records Modeling Mouse Strains Mus Phenotype Physiological Play Population Production Quantitative Trait Loci Quarantine Recombinants Reproducibility Request for Proposals Research Research Personnel Resources Role Sample Size Ships Source Standardization System Technology The Jackson Laboratory Tissues United States National Institutes of Health Variant Vendor Work biobank cost design embryo cryopreservation gene environment interaction gene network genetic manipulation genetic resource human disease member model design outreach personalized medicine preservation repository sperm cell tool trait

项目摘要

PROJECT SUMMARY/ABSTRACT – Overall Component Many aspects of human health and disease are genetically complex; that is, they arise from multiple interactions between genetic, developmental, and environmental factors. Understanding this complexity is the basis of personalized medicine. Unfortunately, human genetic studies are still limited in a number of ways including inadequate, retrospective medical records, formidable sample size requirements, insufficient statistical power to study genetic interactions, and insufficient mechanistic information about many genes. These obstacles are easily addressed using non-human, mammalian models, such as mice, that are designed for fine scale dissection of genetic complexity, i.e. systems genetics. The biomedical research community has made a significant investment in the genetically diverse inbred strains and genetic reference populations of mice as tools for systems genetics research. This proposal requests ongoing support for The Special Mouse Strain Resource (SMSR) at The Jackson Laboratory. The SMSR serves as the biorepository for these unique sets of strains, ensuring permanent and open access from high health status, quality-controlled, state-of-the-art facilities. The resource currently consists of more than 300 strains, including the widely used BXD and Collaborative Cross strain panels, but importantly, the strains available in the SMSR are changed and developed as dictated by the needs of research community. The major activities of the SMSR are to: i) archive, maintain, and distribute these strains to qualified biomedical researchers, ii) provide complete, accurate and accessible information related to the mouse resources, iii) confer with an external advisory board of thought leaders from the complex trait community to define current and future resources, iv) provide leadership in best practices for research and reproducibility using SMSR resources. The SMSR also provides infrastructure, outreach and collaborative opportunities for the development of new tools for complex trait analysis, as well as access to existing strains and populations for large-scale multicenter projects; and conducts research to expand tools for genetic engineering of specialized mapping strains.

项目概要/摘要——整体组成人类健康和疾病的许多方面在遗传上都是复杂的；也就是说，它们是由多种因素引起的。理解遗传、发育和环境因素之间的相互作用是关键。不幸的是，人类遗传学研究在许多方面仍然受到限制。包括不充分、回顾性医疗记录、巨大的样本量要求、不足研究遗传相互作用的统计能力，以及许多基因的机制信息不足。使用非人类哺乳动物模型（例如小鼠）可以轻松解决这些障碍用于遗传复杂性的精细剖析，即生物医学研究界。对遗传多样性近交系和遗传参考群体进行了大量投资小鼠作为系统遗传学研究的工具。该提案要求对杰克逊的特殊小鼠品系资源 (SMSR) 提供持续支持 SMSR 实验室充当这些独特菌株组的生物储存库，确保永久且有效。从高健康状况、质量控制、最先进的设施中开放获取当前资源。由 300 多个菌株组成，包括广泛使用的 BXD 和协作交叉菌株面板，但是重要的是，SMSR 中可用的菌株是根据需求而改变和开发的。研究社区。 SMSR 的主要活动是： i) 归档、维护这些菌株并将其分发给合格的生物医学人员研究人员，ii) 提供与小鼠资源相关的完整、准确和可访问的信息，iii) 与来自复杂特质社区的思想领袖组成的外部咨询委员会进行协商，以定义当前的和未来的资源，iv) 使用 SMSR 为研究和可重复性的最佳实践提供领导力资源。 SMSR 还为新产品的开发提供基础设施、外展和合作机会。用于复杂性状分析的工具，以及获取现有菌株和种群以进行大规模多中心项目；并开展研究以扩展专门绘图菌株的基因工程工具。