Coordination Section

协调科

基本信息

批准号：
10251354
负责人：
Cathleen M Lutz
金额：
$ 20.08万
依托单位：
JACKSON LABORATORY
依托单位国家：
美国
项目类别：
财政年份：
2020
资助国家：
美国
起止时间：
2020-09-01 至 2025-08-31
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10251354
关键词：
Accounting Achievement Awareness Bioinformatics Clinical Clinical Research Clinical Trials Design Communication Communities Consultations Development Disease Disease model Drug usage Ensure Evaluation Foundations Generations Goals Grant Guidelines Human Genetics Human Resources Infrastructure Laboratories Laboratory mice Leadership Letters Marketing Mission Modeling Monitor Participant Play Procedures Process Production Productivity Program Reviews Progress Reports Publications Recommendation Records Reporting Research Resource Development Resources Review Committee Role Schedule Scientist Services Testing The Jackson Laboratory TimeLine United States National Institutes of Health Ursidae Family Variant base drug testing experience genetic resource genetic technology genetic variant innovation meetings member model development mouse model multidisciplinary operation outreach precision genetics preclinical study programs recruit synergism tool web portal web site working group

项目摘要

PROJECT SUMMARY COORDINATION CORE The Jackson Laboratory (JAX) Center for Precision Genetics (JCPG) brings together a multi-disciplinary team including geneticists, genetics technology experts, quantitative and computational biologists, clinical experts and experienced resource managers. The purpose of the Coordination Core (hereafter, Core) is to ensure productive interactions among all participants and to oversee and facilitate all administrative and scientific functions of the JCPG. This function is carried out under the direction of the JCPG Director and the Program Manager in consultation with a Steering Committee (SC) and an External Advisory Board (EAB). Effective coordination of the JCPG will be achieved by accomplishing four Specific Aims: AIM 1. Optimize integration and function of JCPG activities through strong administrative and technical oversight. This includes: i) facilitating the process of nominating disease modeling projects, ii) ensuring integrated operation of the Bioinformatics core, the Disease Modeling Unit and the Pre/Co Clinical core, iii) facilitation of all internal and external JCPG communications, iv) coordination of activities of the SC and EAB and, v) coordinating production and submission of all JCPG records to meet internal and external reporting requirements. AIM 2. Promote center productivity and scientific synergy through effective communication. In this role the Core is responsible for organizing all formal meetings between and among JCPG leadership, advisors and external stakeholders. The purpose of all meetings is to track progress toward aims and milestones and will follow a regular schedule that will be supplemented with ad hoc gatherings as needed. AIM 3. Implement and refine a decision framework for evaluating and prioritizing variant nominations. A central function of the JCPG is to provide a public-facing process for nomination of human genetic variants that either have no existing mammalian research model or for which existing models are inadequate. The JCPG will establish a process that allows nominees to submit variant candidates through a JCPG web portal located on the JAX website (www.jax.org). These nominations will undergo a review process to evaluate feasibility, scientific and community need, and then prioritize the nomination for entry into the pipeline for model production. The JCPG Program Manager will communicate directly with the nominee throughout the process. AIM 4. Outreach and External Communication. The impact of the JCPG is directly related to the number of projects that are nominated and complete development. To maximize awareness for all potential entities that might need new mouse models for research and testing we will: i) leverage an existing extensive network of disease foundations and clinical partners to promote contacts with similar entities that might need mouse models and, ii) employ the extensive marketing and outreach infrastructure of JAX Mice, Clinical and Research Services (JMCRS) to bring worldwide awareness to JCPG activities, models, tools and services.

项目概要协调核心杰克逊实验室 (JAX) 精准遗传学中心 (JCPG) 汇集了多学科团队包括遗传学家、遗传技术专家、定量和计算生物学家、临床专家以及经验丰富的资源经理。协调核心（以下简称“核心”）的目的是确保所有参与者之间富有成效的互动，并监督和促进所有行政和科学 JCPG 的职能。该职能在 JCPG 主任和计划的指导下执行经理与指导委员会 (SC) 和外部顾问委员会 (EAB) 协商。 JCPG 的有效协调将通过实现四个具体目标来实现：目标 1. 通过强有力的行政和管理，优化 JCPG 活动的整合和功能技术监督。这包括：i) 促进疾病建模项目的提名过程，ii) 确保生物信息学核心、疾病建模单元和预/联合临床的集成运行核心，iii) 促进所有内部和外部 JCPG 沟通，iv) 协调 SC 的活动和 EAB，以及，v) 协调所有 JCPG 记录的制作和提交，以满足内部和外部的要求报告要求。目标 2. 通过有效的沟通促进中心生产力和科学协同作用。在这个角色中核心负责组织 JCPG 领导层、顾问和外部利益相关者。所有会议的目的是跟踪目标和里程碑的进展情况以及意愿遵循定期时间表，并根据需要辅以临时聚会。目标 3. 实施和完善用于评估变体提名并确定其优先顺序的决策框架。 JCPG 的核心职能是提供面向公众的人类遗传变异提名流程要么没有现有的哺乳动物研究模型，要么现有模型不足。这 JCPG 将建立一个流程，允许被提名者通过 JCPG 门户网站提交变体候选者位于 JAX 网站 (www.jax.org) 上。这些提名将接受审查程序以评估可行性、科学性和社区需求，然后优先考虑进入模型管道的提名生产。 JCPG 项目经理将在整个过程中直接与被提名者沟通。目标 4. 外展和外部沟通。 JCPG 的影响与 JCPG 的数量直接相关。被提名并完成开发的项目。最大限度地提高所有潜在实体的认识可能需要新的小鼠模型进行研究和测试，我们将：i）利用现有的广泛网络疾病基金会和临床合作伙伴促进与可能需要小鼠的类似实体的接触模型，ii) 采用 JAX Mice、临床和研究的广泛营销和外展基础设施服务 (JMCRS) 让全世界认识到 JCPG 的活动、模型、工具和服务。