Special Mouse Strains Resource

特殊小鼠品系资源

基本信息

批准号：
10400461
负责人：
Cathleen M Lutz
金额：
$ 46.72万
依托单位：
JACKSON LABORATORY
依托单位国家：
美国
项目类别：
财政年份：
2021
资助国家：
美国
起止时间：
2021-07-01 至 2025-01-31
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10400461
关键词：
2019-nCoV ACE2 Address Affect Animal Model Animals Autoimmune Biomedical Research Body Weight COVID-19 Communities Complex DNA sequencing Data Disease Outbreaks Drug or chemical Tissue Distribution Embryo Transfer Exposure to Feces Fertilization in Vitro Gap Junctions Genetic Genetic Variation Genetic study Genome Goals Grant Health Histologic Horizontal Disease Transmission Human Human Genetics Inbred Mouse Inbred Strain Inbreeding Infection Intervention K-18 conjugate Kidney Kinetics Knowledge Laboratory mice Lead Leadership Liver Lung Modeling Monitor Mouse Strains Mus Mutation Pathogenesis Phenotype Policies Population Predisposition Reporting Reproducibility Research Research Infrastructure Resources Reverse Transcriptase Polymerase Chain Reaction SARS-CoV-2 B.1.351 SARS-CoV-2 variant Sampling Sentinel Sexual Reproduction Source South African Spleen Standardization Surveys System Technology Testing The Jackson Laboratory Therapeutic Tissues Transgenic Animals Variant Viral Viral Load result Virus Zoonoses cohort design genetic variant human disease improved infection management insight interest male medical specialties mouse model prevent reproductive organ respiratory response sperm cell transmission process variants of concern viral genomics

项目摘要

Abstract Understanding the effects of genetic diversity on human disease is the nexus of the Specialty Mouse Strains Resource (SMSR) grants. Recent findings that SARS-CoV-2 variants of concern (VOCs) can infect common laboratory mice creates both and opportunity and a concern. The concern is that SARS-CoV-2 has become a zoonotic agent that will impact research using mice. Little is known about how these VOCs will affect laboratory mice, whether mouse-to-mouse transmission is possible, or how to survey vivaria for infection. It is critical that we understand the course of infection, pathogenesis, and transmissibility including through germplasm so that strategies can be developed to protect research that depends on the use of mice. The data generated through this proposal will address these gaps in knowledge and will be of value to those developing policies and practices to prevent or manage outbreaks, protecting the research resources and infrastructure utilizing mice Paradoxically, the infection of VOCs in inbred mice also presents an opportunity. The differential infection among inbred strains for VOCs outlined in this proposal will increase our knowledge of host genetics of infection, providing a tremendous opportunity to improve our overall strategies in the design and use of mouse models for SARS-CoV-2, towards the ultimate goal of testing interventions and therapeutics.

抽象的了解遗传多样性对人类疾病的影响是该专业的核心小鼠品系资源 (SMSR) 拨款。最近的发现表明 SARS-CoV-2 变种值得关注（挥发性有机化合物）可以感染普通实验室小鼠，这既创造了机会，也带来了担忧。这令人担忧的是，SARS-CoV-2 已成为一种人畜共患病原体，将影响小鼠研究。人们对这些挥发性有机化合物将如何影响实验室小鼠（无论是小鼠对小鼠）还是知之甚少传播是可能的，或者如何调查动物的感染情况。至关重要的是我们要了解感染过程、发病机制和传播性，包括通过种质传播，以便可以制定策略来保护依赖于小鼠使用的研究。数据通过该提案产生的成果将解决这些知识差距，并对以下方面有价值：制定政策和实践来预防或管理疫情、保护研究的人员利用小鼠的资源和基础设施矛盾的是，近交小鼠感染挥发性有机化合物也提供了机会。差速器本提案中概述的 VOC 近交系感染将增加我们对以下方面的认识：感染的宿主遗传学，为改善我们的整体策略提供了巨大的机会 SARS-CoV-2小鼠模型的设计和使用，以实现测试的最终目标干预和治疗。