Sensory Processing in the Mouse Accessory Olfactory Bulb

小鼠附件嗅球的感觉处理

• 批准号: 7533985
• 负责人: REBECCA CAPPEL HENDRICKSON
• 金额: $ 2.7万
• 依托单位: WASHINGTON UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-12-09 至 2009-12-08
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7533985
• 关键词: Accessory Olfactory Bulbs; Address; Area; Award; Axon; Behavior; Behavioral; Biology; Birds; Brain; Businesses; Cell Nucleus; Cells; Certification; Cities; Clinical Trials; Code; Contracts; Cues; Detection; Discipline; Doctor of Philosophy; Electronic Mail; Face; Fellowship; Female; Grant; Human; Hypothalamic structure; Individual; Institution; Interneurons; Knowledge; Laboratories; Length; Mediating; Methods; Mus; Names; National Research Service Awards; Neurons; Neurosciences; Output; Pathway interactions; Phase; Pheromone; Process; Reading; Request for Applications; Research; Research Training; Residencies; Science; Sensory; Sensory Process; Services; Source; Stimulus; Street Address; Subcategory; Synapses; System; Telefacsimile; Telephone; Testing; Training; Universities; Washington; extracellular; male; medical schools; pre-doctoral; receptor; response; sex

DESCRIPTION (provided by applicant): Disruptions in sensory processing contribute significantly to the morbidity associated with diseases such as Alzheimer's Disease or following a neurological stroke, yet the neural basis of this processing is poorly understood. The division of the olfactory system used by mice to recognize pheromones provides examples of the basic tasks of sensory processing, but carried out in a set of neural structures that are anatomically simpler and more accessible than most mammalian sensory systems. The limited number of processing locations separating stimulus transduction and behavioral output make this system particularly useful for exploring the mechanisms by which sensory systems extract information about the salient characteristics of natural stimuli, and represent them in a form that can be used to guide behavior. Measuring the activity of the second order neurons of this system during the presentation of natural stimuli has the potential to test a number of hypotheses about how such mechanisms are implemented in the olfactory system. The activity of this cell population will be measured through extracellular recordings.

描述（由申请人提供）：感官处理中的破坏对与阿尔茨海默氏病或​​神经中风等疾病相关的发病率显着促进，但这种处理的神经基础知之甚少。小鼠用来识别信息素的嗅觉系统的划分提供了感觉处理的基本任务的示例，但在一组神经结构中进行的，这些神经结构比大多数哺乳动物的感觉系统更简单，更容易访问。分隔刺激转导和行为输出的加工位置数量有限，使该系统对于探索感觉系统提取有关自然刺激显着特征的信息的机制特别有用，并以可用于指导行为的形式表示它们。在呈现自然刺激期间，测量该系统的二阶神经元的活性具有测试有关嗅觉系统中如何实现此类机制的许多假设。该细胞种群的活性将通过细胞外记录来测量。