Core A: University of Kentucky Alzheimer's Disease Core Center

核心 A：肯塔基大学阿尔茨海默病核心中心

• 批准号: 10459466
• 负责人: LINDA J VAN ELDIK
• 金额: $ 27.88万
• 依托单位: UNIVERSITY OF KENTUCKY
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-08-01 至 2026-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10459466
• 关键词: Administrator; Alzheimer' s Disease; Alzheimer' s Disease Core Center; Alzheimer' s disease related dementia; Autopsy; Biological; Brain; Brain Pathology; Capital; Caregivers; Cessation of life; Clinical; Cognitive; Cognitive aging; Collaborations; Communication; Communities; Dementia; Development; Doctor of Philosophy; Elderly; Ensure; Environment; Etiology; Fostering; Foundations; Goals; Heterogeneity; Human Resources; Human Volunteers; Impaired cognition; Individual; Infrastructure; Kentucky; Knowledge; Leadership; Modality; Monitor; Neurosciences; Occupational activity of managing finances; Pathogenicity; Pathology; Patients; Prevention; Research; Research Activity; Research Personnel; Resources; Risk; Risk Factors; Science; Strategic Planning; Structure; System; Tissues; Training and Education; Translational Research; United States; Universities; accurate diagnostics; beneficiary; cognitive development; cohort; comorbidity; diagnostic strategy; disease heterogeneity; effective therapy; innovation; meetings; multidisciplinary; novel therapeutics; pre-clinical; prevent; programs; success; training opportunity; treatment strategy; volunteer

Project Summary/Abstract: Administrative Core The ultimate goal of the UK-ADRC is to catalyze innovative and outstanding AD research while ensuring a more rapid rate of progress toward new therapies to delay or prevent AD, so that our human volunteers, patients and caregivers become the beneficiaries of our advances in knowledge. The Administrative Core provides the foundation, infrastructure, leadership, overall direction, strategic planning, and integration of all ADRC components to more rapidly achieve this goal and advance our overall theme: “Transitions from Normal to Late-Life Multi-Etiology Dementia”. This theme builds on our traditional strengths in defining mechanisms underlying the early changes that occur in individuals as they transition through the cognitive continuum, risk factors associated with these cognitive states, and how mixed pathology and co-morbidities influence risk and progression. Two historically outstanding resources of the UK-ADRC that enable research relevant to this theme are: 1) a strong autopsy program providing clinical-neuropathological correlation and very short (2-4 hrs) postmortem interval (PMI) research material, and 2) a unique, continuously replenished group of ~500 cognitively intact subjects followed longitudinally, together with another ~300 initially normal individuals who transition to pre-MCI, MCI or dementia, and all committed to brain autopsy upon death. These signature resources have contributed to our becoming one of the premier centers defining pathogenic mechanisms underlying the transitions from normal cognitive aging to the earliest stages of cognitive impairment. The UK- ADRC functions in a multidisciplinary, integrated, collaborative and supportive team science environment that catalyzes high-quality AD research within the UK community, region, nation, and beyond. We will continue to provide the infrastructure, resources and intellectual capital to enhance transdisciplinary research and scientific interactions, develop new collaborations and partnerships, contribute to national initiatives, and offer innovative education and training opportunities in the basic and clinical neurosciences. An effective Administrative Core is essential for transforming our goals into accomplishments. Therefore, the Core will continue to support the ability of our UK-ADRC to accomplish its goals, and to promote the NAPA research implementation milestones and goals, through the following specific aims. Aim 1: Provide leadership, administrative structure, coordination, and financial management to ensure optimal resource utilization to meet the overall goals of the UK-ADRC. Aim 2: Promote and catalyze clinical/translational research activities, maximize interactions with other departments and centers, and foster new avenues of innovative research. Aim 3: Solicit, review, select, and monitor the Developmental Projects. Aim 4: Contribute to and interact with other ADRCs and other national collaborative activities and increase visibility in the local and national community.

项目摘要/摘要：行政核心 UK-ADRC 的最终目标是促进创新和杰出的 AD 研究，同时确保 更快地开发出延缓或预防 AD 的新疗法，以便我们的人类志愿者， 患者和护理人员成为我们知识进步的受益者。 提供基础、基础设施、领导力、总体方向、战略规划和整合 ADRC 组件可以更快地实现这一目标并推进我们的总体主题：“从正常状态的转变 到晚年多病因痴呆症”这一主题建立在我们定义机制的传统优势之上。 个体在认知连续体转变过程中发生的早期变化是潜在的，风险 与这些认知状态相关的因素，以及混合病理学和共病如何影响风险和 UK-ADRC 的两个历史上杰出的资源可实现与此相关的研究 主题是：1）强大的尸检程序，提供临床神经病理学相关性，并且时间很短（2-4小时） 死后间隔 (PMI) 研究材料，以及 2) 一个独特的、持续补充的约 500 人小组 认知完整的受试者与另外约 300 名最初正常的个体一起纵向跟踪 转变为 MCI 前期、MCI 或痴呆症，并且所有患者在死亡时都进行脑部尸检。 资源有助于我们成为定义致病机制的首要中心之一 从正常认知衰老到认知障碍最早阶段的转变的基础。 ADRC 在多学科、综合、协作和支持性团队科学环境中运作， 我们将继续促进英国社区、地区、国家及其他地区的高质量 AD 研究。 提供基础设施、资源和智力资本，以加强跨学科研究和科学 互动，发展新的合作和伙伴关系，为国家举措做出贡献，并提供创新 基础和临床神经科学的教育和培训机会 有效的管理核心是。 对于将我们的目标转化为成就至关重要，因此，核心将继续支持 我们的 UK-ADRC 实现其目标并促进 NAPA 研究实施里程碑的能力 和目标，通过以下具体目标。 目标 1：提供领导、行政结构、协调和财务管理，以确保最佳 资源利用以满足 UK-ADRC 的总体目标。 目标 2：促进和催化临床/转化研究活动，最大限度地与其他人互动 部门和中心，并培育创新研究的新途径。 目标 3：征求、审查、选择和监督开发项目。 目标 4：为其他 ADRC 和其他国家合作活动做出贡献并与之互动，并增加 在当地和国家社区的知名度。