University of Kentucky Alzheimer's Disease Research Center

肯塔基大学阿尔茨海默病研究中心

• 批准号: 10662314
• 负责人: LINDA J VAN ELDIK
• 金额: $ 288.09万
• 依托单位: UNIVERSITY OF KENTUCKY
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-08-01 至 2026-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10662314
• 关键词: Address; African American; Aging; Alzheimer' s Disease; Area; Autopsy; Awareness; Basic Science; Biological; Biological Markers; Biometry; Brain; Caring; Cessation of life; Clinical; Clinical Research; Clinical Trials; Cognitive; Cognitive aging; Collaborations; Collection; Communities; Community Health Education; Community Outreach; Dedications; Dementia; Development; Disease; Early identification; Education; Elderly; Ensure; Environment; Etiology; Family; Goals; Health Personnel; Heterogeneity; Impaired cognition; Impairment; Individual; Infrastructure; Institution; Kentucky; Knowledge; Longitudinal cohort; Mission; Neurodegenerative Disorders; Outcome; Pathogenicity; Pathology; Recommendation; Research; Research Personnel; Research Project Grants; Resources; Risk; Scholars Program; Training; Translating; Translational Research; United States; United States National Institutes of Health; Universities; aging brain; beneficiary; central database; clinical practice; cohort; collaborative environment; community partnership; comorbidity; data management; driving force; education research; experience; innovation; neuropathology; next generation; normal aging; novel therapeutics; outreach; pre-clinical; programs; recruit; research study; statistics; success; volunteer

Project Summary/Abstract: Overall The University of Kentucky Alzheimer’s Disease Research Center (UK-ADRC) is an experienced and collaborative center that has facilitated pioneering research in AD and related dementias (ADRD) since its inception in 1985. Our principal mission is to serve as the focal point for all AD-related activities at UK and this region of the United States, by providing an environment and core resources that catalyze innovative research, outreach, education, and clinical programs. Our signature resources include: 1) a cognitively normal group of ~500 subjects followed longitudinally, together with ~300 additional subjects who transitioned to MCI or dementia, and all committed to brain autopsy upon death; 2) a strong autopsy program with clinical- neuropathological correlations and short postmortem interval research material; 3) a maturing program studying the early preclinical biological emergence of mixed pathologies and how they contribute to late life dementia states, with an increasing focus on antemortem biomarker collection; 4) an integrated centralized database and innovative biostatistical expertise to characterize clinical and biological transitions; 5) a successful and close partnership with the African-American community and increased participation of underrepresented individuals in our longitudinal cohort and ADRC-affiliated research studies and clinical trials; and 6) a rich, interdisciplinary training environment that provides multi-faceted educational opportunities for researchers, healthcare providers, and our community partners. The overarching theme of the UK-ADRC is: Transitions from Normal to Late-Life Multi-Etiology Dementia. Our well-characterized, longitudinal cohort and historically strong neuropathology program focused on normal aging, preclinical disease states and early cognitive transitions have been central to our success in defining early pathogenic mechanisms underlying the transitions from normal cognitive aging to impairment. In addition, these efforts have been a driving force in our recognition of the heterogeneity and multiple pathologies that characterize late-life dementia. The UK-ADRC will continue to leverage our strengths to enhance our impact and “Centerness” by our focus on this overarching theme, and the pursuit of four overall specific aims. Aim 1. Facilitate and enhance basic, translational and clinical research in AD and related dementias. Aim 2. Provide the necessary resources and interactive environment to support and create new opportunities for innovative research. Aim 3. Maintain and grow educational opportunities and community partnerships to promote awareness, increase participation in research, and provide an innovative and interdisciplinary training environment. Aim 4. Contribute to the national efforts and collaborative activities with other centers, programs and groups to advance AD/ADRD research, education, and care.

项目摘要/摘要：总体 肯塔基大学阿尔茨海默病研究中心 (UK-ADRC) 是一家经验丰富、 该合作中心自成立以来一直促进 AD 和相关痴呆症 (ADRD) 的开创性研究 成立于 1985 年。我们的主要使命是成为英国所有与 AD 相关的活动的焦点 美国地区，通过提供促进创新研究的环境和核心资源， 我们的标志性资源包括：1) 认知正常的群体。 约 500 名受试者进行纵向随访，另外还有约 300 名受试者过渡到 MCI 或 痴呆症，以及所有在死亡后进行脑部尸检的人；2）具有临床意义的强有力的尸检计划； 神经病理学相关性和短死后间隔研究材料；3）成熟的计划； 研究混合病理的早期临床前生物学出现以及它们如何影响晚年 痴呆症状态，越来越关注生前生物标志物收集 4) 综合集中化； 用于表征临床和生物学转变的数据库和创新的生物统计专业知识；5) a 与非裔美国人社区建立成功和密切的伙伴关系，并增加非裔美国人的参与 在我们的纵向队列和 ADRC 附属研究和临床试验中代表性不足的个体； 6) 丰富的跨学科培训环境，为学生提供多方面的教育机会 英国 ADRC 的首要主题是： 从正常到晚年多病因痴呆的转变我们的特征明确的纵向队列。 历史上强大的神经病理学项目专注于正常衰老、临床前疾病状态和早期 认知转变对于我们成功定义早期致病机制至关重要 此外，这些努力一直是我们从正常认知衰老向损伤转变的驱动力。 认识到晚年痴呆症的异质性和多种病理学特征。 我们将继续利用我们的优势，通过专注于此来增强我们的影响力和“中心性” 总体主题，并追求四个总体具体目标。 目标 1. 促进和加强 AD 及相关痴呆症的基础、转化和临床研究。 目标 2. 提供必要的资源和互动环境来支持和创造新的机会 用于创新研究。 目标 3. 维持和增加教育机会和社区伙伴关系，以提高认识、 增加对研究的参与，并提供创新和跨学科的培训环境。 目标 4. 为国家努力以及与其他中心、计划和团体的合作活动做出贡献， AD/ADRD 研究、高级教育和护理。

项目成果

Glucose Metabolism is a Better Marker for Predicting Clinical Alzheimer's Disease than Amyloid or Tau.

与淀粉样蛋白或 Tau 蛋白相比，葡萄糖代谢是预测临床阿尔茨海默病的更好标志物。

• 发表时间: 2022
• 作者: Hammond, Tyler C;Lin, Ai
• 通讯作者: Lin, Ai

The space-time profiles of sleep spindles and their coordination with slow oscillations on the electrode manifold.

睡眠纺锤体的时空分布及其与电极歧管上缓慢振荡的协调。

• 发表时间: 2022-08-11
• 影响因子: 5.6
• 作者: Malerba, Paola;Whitehurst, Lauren;Mednick, Sara C
• 通讯作者: Mednick, Sara C

Multi-compartment diffusion magnetic resonance imaging models link tract-related characteristics with working memory performance in healthy older adults.

多室扩散磁共振成像模型将健康老年人的束相关特征与工作记忆表现联系起来。

• 发表时间: 2022
• 作者: Bauer, Christopher E;Zachariou, Valentinos;Maillard, Pauline;Caprihan, Arvind;Gold, Brian T
• 通讯作者: Gold, Brian T

The Role of Working Memory in Age-Related Emotional Memory Bias.

工作记忆在与年龄相关的情绪记忆偏差中的作用。

• 发表时间: 2022-09
• 作者: Sattari, Negin;Whitehurst, Lauren N;Mednick, Sara C
• 通讯作者: Mednick, Sara C

Soluble TNF mediates amyloid-independent, diet-induced alterations to immune and neuronal functions in an Alzheimer's disease mouse model.

在阿尔茨海默病小鼠模型中，可溶性 TNF 介导不依赖淀粉样蛋白、饮食诱导的免疫和神经元功能改变。

• 发表时间: 2023
• 作者: MacPherson, Kathryn P;Eidson, Lori N;Houser, Madelyn C;Weiss, Blaine E;Gollihue, Jenna L;Herrick, Mary K;de Sousa Rodrigues, Maria Elizabeth;Sniffen, Lindsey;Weekman, Erica M;Hamilton, Adam M;Kelly, Sean D;Oliver, Danielle L;Yang, Yuan;Chang
• 通讯作者: Chang