Developmental Projects

发展项目

• 批准号: 7490292
• 负责人: ROBERT F MATTREY
• 金额: $ 12万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN DIEGO
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-04-01 至 2013-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7490292
• 关键词: Antibodies; Award; B lymphoid malignancy; B-Cell Development; B-Lymphocytes; Binding; Biological; Blood; Blood specimen; Budgets; Cancer Center; Cell Line; Cell Wall; Cell membrane; Cells; Clinical; Commit; Complex; DNA; DNA Sequence; DNA delivery; Development; Doctor of Philosophy; Drug Formulations; Ensure; Frequencies; Funding; Funding Agency; Funding Opportunities; Gases; Gene Delivery; Genes; Goals; Green Fluorescent Proteins; In Vitro; Integral Membrane Protein; Internal Medicine; Label; Localized; Lymphoma; MS4A1 gene; Mediating; Microbubbles; Microscopy; Monoclonal Antibody CD20; Mus; Neoplasms; Nucleic Acids; One-Step dentin bonding system; Pharmaceutical Preparations; Principal Investigator; Radiology Specialty; Research Personnel; Resources; Review Committee; Small Interfering RNA; Staging; Stem cells; TNFRSF5 gene; TNFSF5 gene; Testing; Therapeutic Uses; Transfection; Ultrasonography; Water; abstracting; base; blood fractionation; cancer therapy; design; in vivo; neoplastic cell; plasmid DNA; rituximab; sonoporation; transgene expression; tumor

Development Projects and Funds Total Budget: $120,000/year. As stated earlier, the $120,000 proposed with this submission is not fixed. It may increase or decrease depending upon the needs, available funds, available projects in the portfolio and programmatic oversight. Development funds will be supported from the general pool as well as other funding opportunities through the Cancer Center and other internal and external funding sources. The three projects presented here were the three that ranked the highest by the Scientific Review Committee that reviewed eight 1-page abstracts for inclusion in this submission. Two of the three submitted last year were again chosen for inclusion. The committee felt that their scientific and clinical implications were not adequately presented. The third project submitted last year was recent funding by the DOD. It was replaced by a projected submitted by a rising start in stem cell neoplasia. As emphasized these three projects might not be the ones we will fund should the P50 be awarded. Upon release of funds, the Scientific Steering Committee will again solicit submissions and will review the portfolio of projects and select the most appropriate and highest ranked for funding that the Steering Committee will need to approve. This is important since the field is changing rapidly, new opportunities are coming on line frequently, and these Development Projects that are ready to begin since all the resources are available, may get funded and will no longer when the P50 is ready to begin. Development Project #1: Ultrasound Targeted Gene Delivery in B-Cell Malignancies Principal Investigator: Dmitri Simberg, Ph.D.1 Co-Investigators: Robert F. Mattrey, M.D.2 and Thomas J. Kipps, M.D.3, Ph.D. Departments: Moores Cancer Center (1) Radiology (2) and Internal Medicine (3)

开发项目和资金 总预算：每年$ 120,000。 如前所述，此提交提出的120,000美元未固定。它可能会增加或减少 根据需求，可用资金，投资组合和程序性监督的可用项目。 开发资金将得到一般游泳池的支持以及其他资金机会 癌症中心以及其他内部和外部资金来源。 这里提出的三个项目是科学评论排名最高的三个项目 审查了八个1页摘要的委员会，以包含在此提交中。提交的三个 去年再次被选为包容。委员会认为他们的科学和临床意义是 没有充分呈现。去年提交的第三个项目是国防部最近的资金。是 取而代之的是，在干细胞肿瘤中提出的预计提交的预测。 正如强调这三个项目的那样，如果授予P50，我们将资助。之上 释放资金，科学指导委员会将再次征求意见书，并将审查 项目并选择指导委员会需要的最合适和最高排名 批准。这很重要，因为该领域正在迅速变化，新的机会即将到来 经常，以及这些准备开始的开发项目，因为所有资源都可用，可能 得到资助，当P50准备开始时将不再。 开发项目＃1：B细胞恶性肿瘤中超声靶向基因输送 首席研究员：Dmitri Simberg博士1 共同研究人员：Robert F. Mattrey，M.D.2和Thomas J. Kipps，M.D.3，博士学位 部门：摩尔癌中心（1）放射学（2）和内科（3）