Small Animal Imaging Core

小动物成像核心

基本信息

批准号：
7490273
负责人：
Thomas E Yankeelov
金额：
$ 11.96万
依托单位：
VANDERBILT UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2008
资助国家：
美国
起止时间：
2008-09-22 至 2013-08-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/7490273
关键词：
Accounting Address Affect Animal Cancer Model Animals Apoptosis Arts Award Benchmarking Biological Markers Budgets Cell Proliferation Cellularity Colon Carcinoma Complement Critiques Data Detection Development Disease regression Doctor of Philosophy Educational workshop Effectiveness Electronics Equipment Evaluation Faculty Fostering Funding Goals Grant Group Meetings Hand Hearing Histology Hour Human Resources Image Image Analysis Imaging technology Institution Invasive Label Laboratories Length Magnetic Resonance Imaging Malignant Neoplasms Maps Mass Spectrum Analysis Matrix Metalloproteinases Measures Methods Metric Modality Molecular Molecular Profiling Monitor Nuclear Operative Surgical Procedures Optics Peptide Library Physiological Positioning Attribute Positron-Emission Tomography Preparation Process Proteomics Protocols documentation Published Comment Purpose Recommendation Reporting Research Research Infrastructure Research Personnel Resources Science Services Small Animal Imaging Resource Programs Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization Support of Research Techniques Tumor Burden Ultrasonography X-Ray Computed Tomography angiogenesis animal care cancer imaging cancer therapy computing resources design experience improved in vivo in vivo Cellular and Molecular Imaging Centers inhibitor/antagonist instrumentation interest knowledge base novel programs response single photon emission computed tomography success tumor tumor growth

项目摘要

INTRODUCTION TO THE REVISED SMALL ANIMAL IMAGING CORE We thank the reviewers of our initial proposal for a Small Animal Imaging Core (SAIC) for their careful and considerate critique that included many helpful recommendations for improving the administration and overall effectiveness of the Core. We were encouraged to hear that the reviewers agreed that, "the Small Animal Imaging Core is central to the success of the ICMIC application", and that (as expressed by Reviewer 2) "each Core has excellent facilities and staff to accomplish the tasks at hand." The reviewers clearly appreciated the aims and abilities of the Core, and that there is a cohesive plan to provide service and expertise to all four primary projects as well as selected developmental projects. We were also pleased to hear that Reviewer 1 found that our efforts "correlating imaging data with mass spectrometry is wonderful." In our revised description, we have taken account of all the reviewers' comments and criticisms. Specific concerns about the care of animals for imaging are also dealt with at length in our revised Section G. Of additional note, since the original submission, our animal imaging center has become an NCI designated Small Animal Imaging Resource Program (PI: John Gore), funded for the next 5 years. This award provides additional support, infrastructure and organization for the animal imaging program and will facilitate the services and developments required for the ICMIC. As a result we have been able to modify the budget to support additional capabilities and believe these changes have significantly strengthened our proposal.

修订的小动物成像核心简介我们感谢我们最初提出小型动物成像核心（SAIC）的评论者的谨慎和体贴的批评，其中包括许多有用的建议，以改善管理和整体核心的有效性。鼓励我们听到审稿人同意：“小动物成像核心是ICMIC应用程序成功的核心“，并且（按评论者2表示）” 核心拥有出色的设施和员工来完成手头的任务。核心的目标和能力，并且有一个凝聚力的计划，可以为所有四个提供服务和专业知识主要项目以及选定的发展项目。我们也很高兴听到审稿人1 发现我们的努力“将成像数据与质谱相关联是很棒的。”在我们的修订中描述，我们已经考虑了所有审稿人的评论和批评。对在我们修订的G.部分中，对动物进行成像的护理也详细介绍了其他注意事项，因为原始提交，我们的动物成像中心已成为NCI指定的小动物成像资源计划（PI：John Gore），在接下来的5年中资助。该奖项提供了额外的支持，动物成像计划的基础设施和组织，将促进服务和 ICMIC所需的发展。结果，我们已经能够修改预算以支持其他能力并相信这些变化极大地加强了我们的建议。