COGNITIVE FUNCTION IN THE AGED MONKEY

老年猴子的认知功能

• 批准号: 7617233
• 负责人: JOHN H MORRISON
• 金额: $ 44.57万
• 依托单位: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI
• 依托单位国家: 美国
• 财政年份: 1992
• 资助国家: 美国
• 起止时间: 1992-09-20 至 2011-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7617233
• 关键词: 18 year old; Accounting; Address; Adopted; Aging; Animals; Behavior assessment; Behavioral; Biological Neural Networks; Characteristics; Cognitive; Cognitive aging; Coupled; Data; Endocrine; Episodic memory; Event; Familiarity; Feasibility Studies; Female; Functional disorder; Generations; Goals; Hippocampus (Brain); Hormones; Human; Image; Impairment; Investigation; Learning; Left; Lesion; Link; Macaca mulatta; Magnetic Resonance Imaging; Maps; Medial; Memory; Memory impairment; Menopause; Menstruation; Metabolic; Monitor; Monkeys; Nature; Neurobiology; Outcome; Ovarian; Ovarian hormone; Ovariectomy; Positron-Emission Tomography; Prefrontal Cortex; Primates; Procedures; Process; Relative (related person); Research; Research Personnel; Resolution; Risk Factors; Sampling; Scanning; Structure; System; Targeted Research; Temporal Lobe; Testing; Visual; age effect; age related; aged; base; cognitive function; fluorodeoxyglucose; functional decline; information processing; interdisciplinary approach; interest; memory process; memory recognition; neurophysiology; neuropsychological; normal aging; programs; relating to nervous system; research study; response; senescence; tool; young adult

DESCRIPTION (provided by applicant): Experiments proposed in this application bring into convergence current progress from the broader field of learning and memory research with recent findings in aged monkeys, toward addressing a new generation of questions concerning the neurobiology of normal cognitive aging in primates. The overall aims of the research program are to define the effects of normal aging on the information processing capacities that enable episodic memory, and to test the proposal that age-related decline results from large-scale restructuring of the neural networks critical for memory, regulated in part by ovarian senescence. Fourteen young adult (~5-10 years) and 18 aged (~22-28 years) female rhesus monkeys will be tested across an extensive neuropsychological battery consisting of both conventional, well-established procedures, including repeated assessment on the classic delayed response test, and a number of recently validated tasks aimed at assessing key operating characteristics of memory. Including standard tests of learning and memory is important to provide continuity with our earlier behavioral studies, and importantly, to establish a baseline for gauging the relative sensitivity and selectivity of newer tests to age-related impairment. These latter tasks will evaluate candidate processing functions and representational capacities thought to enable episodic memory: 1) the contribution of recollection and familiarity to visual recognition, 2) the temporal organization of memory, 3) memory for the context in which events occur, and 4) the relational organization of memory. By defining the specific nature of age-related memory impairment, the aim is to establish an optimally sensitive framework for relating functional decline to underlying neurobiological and endocrine changes. Toward this end, behaviorally characterized monkeys will receive annual structural magnetic resonance imaging (MRI) and positron emission tomography (PET) scans with the goal of testing several targeted hypotheses about the integrity of neural systems critical for normal memory, in close temporal contiguity with behavioral assessment. The results will also be evaluated by exploratory SPM analysis, suited to revealing unanticipated regions of age-related metabolic change. Continuing a long-standing theme of the project, menses activity and ovarian hormone profiles will be documented regularly for all subjects over the course of the experiments. By this integrated, multidisciplinary approach, the overall aim is to establish a unified account of the critical relationships between cognitive, neurobioological and endocrine consequences of normal aging in primates.

描述（由申请人提供）：本申请中提出的实验带来了从更广泛的学习和记忆研究领域的融合进展，并在老年猴子中发现了最新的发现，以解决有关灵长类动物正常认知衰老神经生物学的新一代问题。研究计划的总体目的是定义正常衰老对能够发作记忆的信息处理能力的影响，并测试该提议，即与年龄相关的下降是由于对记忆至关重要的神经网络的大规模重组，部分受卵巢衰老的调节。 14名年轻人（约5-10岁）和18岁（约22-28岁）的女性恒河猴将在广泛的神经心理电池中进行测试，包括传统的，完善的程序，包括对经典延迟响应测试的重复评估，以及许多最近经过验证的旨在评估关键操作特征的最近验证的任务。包括学习和记忆的标准测试对于提供我们较早的行为研究的连续性很重要，并且重要的是建立一个基线，以测量新测试对与年龄相关的障碍的相对灵敏度和选择性。这些后一个任务将评估候选处理功能和表示能够实现情节记忆的代表性能力：1）回忆和熟悉对视觉识别的贡献，2）记忆的时间组织，3）记忆发生的情况，以及发生事件的上下文，4）4）记忆的关系组织。通过定义与年龄相关的记忆障碍的特定性质，目的是建立一个对功能下降与潜在神经生物学和内分泌变化的最佳敏感框架。为此，行为表征的猴子将接受年度结构磁共振成像（MRI）和正电子发射断层扫描（PET）扫描，目的是测试几种针对性的关于神经系统完整性对正常记忆至关重要的有针对性的假设，在与行为评估的紧密相关性下，具有近距离的连续性。结果还将通过探索性SPM分析来评估，该分析适合揭示与年龄相关的代谢变化的意外区域。在整个实验过程中，将定期记录该项目的长期主题，月经活动和卵巢激素概况。通过这种综合，多学科的方法，总体目的是建立统一的描述，即对灵长类动物正常衰老的认知，神经生物学和内分泌后果之间的关键关系。