COGNITIVE FUNCTION IN THE AGED MONKEY

老年猴子的认知功能

• 批准号: 8357247
• 负责人: JOHN H MORRISON
• 金额: $ 17.75万
• 依托单位: UNIVERSITY OF CALIFORNIA AT DAVIS
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-05-01 至 2012-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8357247
• 关键词: Age-associated memory impairment; Aging; Brain region; California; Funding; Grant; Hippocampus (Brain); Image; MRI Scans; Macaca mulatta; Monkeys; National Center for Research Resources; Neurocognitive; Outcome; Ovarian; Primates; Principal Investigator; Research; Research Infrastructure; Resources; Source; Steroids; Testing; United States National Institutes of Health; aged; cognitive function; cost; fluorodeoxyglucose positron emission tomography; memory process; normal aging; reproductive; senescence

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. Ongoing research in this project is aimed at characterizing the effects of normal aging on the memory processing functions of the hippocampus and related brain regions in rhesus monkeys. Subjects receive MRI scans and FDG PET imaging annually and the findings are evaluated in relation to signatures of age-related cognitive decline. Naturally occurring reproductive senescence is also tracked in order to test the influence of ovarian steroid decline on the neurocognitive outcome of aging.

该子项目是利用资源的众多研究子项目之一 由 NIH/NCRR 资助的中心拨款提供。子项目的主要支持 并且子项目的主要研究者可能是由其他来源提供的， 包括其他 NIH 来源。 子项目可能列出的总成本 代表子项目使用的中心基础设施的估计数量， NCRR 赠款不直接向子项目或子项目工作人员提供资金。 该项目正在进行的研究旨在表征正常衰老对恒河猴海马体和相关大脑区域的记忆处理功能的影响。受试者每年接受 MRI 扫描和 FDG PET 成像，并根据与年龄相关的认知能力下降的特征对结果进行评估。还跟踪自然发生的生殖衰老，以测试卵巢类固醇下降对衰老神经认知结果的影响。