MyPEEPS Mobile LITE: Limited Interaction Efficacy Trial of MyPEEPS Mobile to Reduce HIV Incidence and Better Understand the Epidemiology of HIV among YMSM

MyPEEPS Mobile LITE：MyPEEPS Mobile 的有限交互功效试验可降低 YMSM 中的 HIV 发病率并更好地了解 HIV 流行病学

• 批准号: 10462265
• 负责人: Dustin T Duncan
• 金额: $ 180万
• 依托单位: COLUMBIA UNIVERSITY HEALTH SCIENCES
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-09-01 至 2024-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10462265
• 关键词: 18 year old; AIDS prevention; Accounting; Address; Advertisements; Advertising; Affect; Age; Age-Years; Alcohol consumption; Anxiety; Behavior; Behavioral Model; Bisexual; Black race; Clinical Trials; Code; Cohort Studies; Communities; Crime; Data; Discrimination; Enrollment; Epidemic; Epidemiology; Ethnic Origin; Evidence based intervention; Facebook; Frequencies; Funding; Future; Gays; Geographic Locations; HIV; HIV Infections; HIV Seronegativity; HIV Seropositivity; HIV diagnosis; HIV risk; Hot Spot; Incidence; Individual; Individual Differences; Institution; Intervention; Intervention Studies; Knowledge; Latino; Literature; Measures; Mediator of activation protein; Mental Depression; Methods; Modeling; Motivation; Neighborhoods; Outcome; Participant; Persons; Phase; Policies; Population; Positioning Attribute; Poverty; Prevalence; Prevention Research; Principal Investigator; Public Policy; Race; Randomized; Recording of previous events; Reporting; Research; Research Design; Research Personnel; Risk; Risk Reduction; Rural; Same-sex; Sample Size; Sampling; Science; Self Efficacy; Techniques; Testing; Time; Treatment Efficacy; Twitter; United States; United States National Institutes of Health; Unsafe Sex; arm; base; behavior change; cisgender; cohort; condomless anal sex; digital; efficacy testing; efficacy trial; epidemiology study; ethnic diversity; evidence base; experience; health care service; health seeking behavior; high risk; human old age (65+); innovation; innovative technologies; intervention effect; intimate partner violence; longitudinal analysis; mHealth; male; men who have sex with men; minority children; peer; pre-exposure prophylaxis; preventive intervention; racial and ethnic; racial diversity; recruit; research study; response; retention rate; seroconversion; sexual minority; sexual risk behavior; social; social media; social stigma; standard of care; substance use; success; theories; therapy development; transmission process; tribal lands; uptake; virtual; young men who have sex with men; 18 year old; AIDS prevention; Accounting; Address; Advertisements; Advertising; Affect; Age; Age-Years; Alcohol consumption; Anxiety; Behavior; Behavioral Model; Bisexual; Black race; Clinical Trials; Code; Cohort Studies; Communities; Crime; Data; Discrimination; Enrollment; Epidemic; Epidemiology; Ethnic Origin; Evidence based intervention; Facebook; Frequencies; Funding; Future; Gays; Geographic Locations; HIV; HIV Infections; HIV Seronegativity; HIV Seropositivity; HIV diagnosis; HIV risk; Hot Spot; Incidence; Individual; Individual Differences; Institution; Intervention; Intervention Studies; Knowledge; Latino; Literature; Measures; Mediator of activation protein; Mental Depression; Methods; Modeling; Motivation; Neighborhoods; Outcome; Participant; Persons; Phase; Policies; Population; Positioning Attribute; Poverty; Prevalence; Prevention Research; Principal Investigator; Public Policy; Race; Randomized; Recording of previous events; Reporting; Research; Research Design; Research Personnel; Risk; Risk Reduction; Rural; Same-sex; Sample Size; Sampling; Science; Self Efficacy; Techniques; Testing; Time; Treatment Efficacy; Twitter; United States; United States National Institutes of Health; Unsafe Sex; arm; base; behavior change; cisgender; cohort; condomless anal sex; digital; efficacy testing; efficacy trial; epidemiology study; ethnic diversity; evidence base; experience; health care service; health seeking behavior; high risk; human old age (65+); innovation; innovative technologies; intervention effect; intimate partner violence; longitudinal analysis; mHealth; male; men who have sex with men; minority children; peer; pre-exposure prophylaxis; preventive intervention; racial and ethnic; racial diversity; recruit; research study; response; retention rate; seroconversion; sexual minority; sexual risk behavior; social; social media; social stigma; standard of care; substance use; success; theories; therapy development; transmission process; tribal lands; uptake; virtual; young men who have sex with men

PROJECT SUMMARY There is a critical need to better understand the epidemiology of HIV acquisition in the United States (US), particularly among cisgender gay, bisexual and other men who have sex with men (MSM), one of the key populations essential to target for End the HIV Epidemic (EHE) initiatives. In direct response to RFA-AI-21-018, this study will use innovative technology to recruit and retain a large cohort of high-risk, HIV-negative young men who have sex with men (YMSM) focusing on racial/ethnic minority YMSM and high HIV prevalence geographic areas (known as “hot spots”). Furthermore, we will leverage this cohort to conduct a large-scale clinical trial while maintaining the standard of care control arm as a longitudinal observational cohort for epidemiologic analyses. Our study team is uniquely positioned and has all the relevant expertise to conduct this study having successfully recruited and retained more than 12,000 YMSM in a full range of research studies across the HIV continuum (e.g., epidemiology, intervention development, mHealth, PrEP, clinical trials, innovative geospatial methods). We have had specific success conducting prevention research with YMSM (17-25 years), including racially and ethnically diverse YMSM, our target demographic group. Further, we have previously leveraged advanced social media advertising techniques and used innovative geospatial analytics to target/study “communities within communities”, reaching hard-to-reach YMSM from diverse geographic areas (e.g., rural zip codes, U.S. tribal lands, etc.) and young ages (e.g., YMSM 13-18 years of age). We will harness innovative technology to recruit, during 36-months of enrollment, and then retain a large cohort (N = 5,000) of 17-25 year old YMSM, the majority being Black and Latino, who are at high-risk of HIV transmission (e.g., history of condomless anal sex) and follow them every 6 months thereafter. We will conduct an entirely virtual, digital clinical trial (Specific Aim #1) testing whether MyPEEPS Mobile (an evidence-based mHealth HIV prevention intervention) reduces HIV incidence among HIV-negative YMSM (17-25 years old) looking at the influence of theory-driven social, ecological, and geospatial factors on intervention uptake and efficacy inclusive of measures that align with traditional models of behavior change such as the Information Motivation Behavior Model. A social-ecological theoretical framework will also guide the analysis of the longitudinal observational cohort study (Specific Aim #2) of the 2,500 control arm participants to assess individual, network, geospatial, and public policy correlates of HIV risk and health seeking behaviors (e.g., PrEP uptake) comparing individuals who become HIV-positive to those who do not. Intervention Implications. The findings from this research will have important real-world implications for research and practice. For example, understanding how individual, network, geospatial, and public policy factors correlate with HIV incidence and moderate intervention effects will help inform how and where interventions should be delivered.

项目摘要 迫切需要更好地了解美国（美国）的艾滋病毒收购的流行病学， 特别是与男同性恋者，双性恋和其他与男人发生性关系的男人（MSM）中的关键之一 目标是结束HIV流行（EHE）倡议所必需的人群。直接回应RFA-AI-21-018， 这项研究将使用创新技术来招募和保留大量高风险，HIV阴性的年轻人 与男性发生性关系的男性（YMSM）专注于种族/族裔少数民族YMSM和高​​艾滋病毒患病率 地理区域（称为“热点”）。此外，我们将利用此队列进行大规模进行 临床试验，同时将护理控制臂的标准作为纵向观察队列 流行病学分析。我们的学习团队独特地定位，并拥有所有相关专家来进行 这项研究成功地招募并保留了12,000多个YMSM。 跨HIV连续性的研究（例如流行病学，干预开发，MHealth，PREP，临床试验， 创新的地理空间方法）。我们已经与YMSM进行了特定的成功进行预防研究 （17-25岁），包括我们的目标人群群体大致和种族多样化的YMSM。此外，我们还有 以前利用了高级社交媒体广告技术，并使用了创新的地理空间分析 目标/研究“社区内的社区”，从分歧地理上到达难以到达的YMSM 区域（例如粗邮编，美国部落土地等）和年轻人（例如，YMSM 13-18岁）。我们将 利用创新技术，在入学率36个月期间招募，然后保留一个大型队列（n = 5,000）17-25岁的YMSM，大多数是黑人和拉丁裔，他们处于艾滋病毒传播的高风险 （例如，无避孕套肛交的历史），此后每6个月跟随它们。我们将完全进行 虚拟，数字临床试验（特定目标＃1）测试MyPeep是否移动 预防干预）减少了HIV阴性YMSM（17-25岁）的HIV事件 理论驱动的社会，生态和地理空间因素对干预和效率的影响 包括与传统行为变化模式相符的措施，例如信息动机 行为模型。社会生态学理论框架还将指导纵向的分析 2,500个对照组参与者的观察队列研究（特定目的＃2）评估个人，网络， 地理空间和公共政策相关的艾滋病毒风险和健康寻求行为（例如，预先吸收）比较 与不这样做的人成为艾滋病毒阳性的人。干预含义。从中的发现 研究将对研究和实践具有重要的现实影响。例如，了解如何 个人，网络，地理空间和公共政策因素与HIV事件和现代化有关 干预效果将有助于告知应提供干预措施的方式和何处。