Cannabis use, PrEP and HIV transmission risk Among Black MSM in Chicago

芝加哥黑人男男性接触者中的大麻使用、PrEP 和艾滋病毒传播风险

• 批准号: 10674924
• 负责人: Dustin T Duncan
• 金额: $ 72.15万
• 依托单位: COLUMBIA UNIVERSITY HEALTH SCIENCES
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-08-01 至 2026-05-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10674924
• 关键词: AIDS prevention; Address; Adherence; Alcohols; Awareness; Behavior; Biological; Biological Markers; Bisexual; Black race; COVID-19; COVID-19 pandemic; Cannabis; Characteristics; Chicago; Cognitive; Cohort Studies; Data; Disparity; Drug usage; Ecological momentary assessment; Enrollment; Environment; Epidemic; Epidemiology; Equity; Event; Face; Funding; Gays; HIV; HIV Infections; HIV Seronegativity; HIV/AIDS; HIV/STD; Immune; Immunology; Incidence; Individual; Inflammation; Infrastructure; Intervention; Knowledge; Legal; Link; Measures; Mediating; Mediator; Methods; Neighborhoods; Outcome; Participant; Pharmaceutical Preparations; Plasma; Policies; Population; Populations at Risk; Prevention; Prospective, cohort study; Public Health; Rectum; Reporting; Research; Risk; Role; Sex Behavior; Shelter facility; Social Network; Stimulant; Surveys; Technology; Typology; United States; United States National Institutes of Health; Visit; biobehavior; black men who have sex with men; cohort; cytokine; health inequalities; immune function; innovation; marijuana use; men; men who have sex with men; polysubstance use; pre-exposure prophylaxis; racial minority population; rectal; response; sexual minority group; sexual risk behavior; social; substance use; therapy development; transmission process; uptake

PROJECT SUMMARY Black gay, bisexual and other men who have sex with men (MSM) face a disproportionate burden of HIV. Focused, high-coverage PrEP in populations heavily impacted by HIV, such as Black MSM, could rapidly reduce new HIV acquisition rates; however, its uptake among at-risk populations, especially Black MSM, has been limited. Therefore, we propose to conduct urgently needed research on PrEP in a cohort of Black MSM, including on the impact of relevant behaviors, particularly cannabis use, which is highly prevalent in Black MSM. Research on the impact of cannabis use on PrEP has achieved conflicting results, and it has not been rigorously studied in Black MSM. Therefore, the proposed R01 study will assess cross-sectional and longitudinal associations between cannabis use and PrEP outcomes (e.g., use, adherence) and HIV transmission risk (e.g. biological inflammation, sexual risk behavior) using event-level and objective biomarker data among HIV-negative Black SMM. To address these specific aims, we will conduct the Networks and Neighborhoods (N2) Cannabis PrEP Study in Chicago, IL. We will follow 250 HIV-negative participants from the original N2 cohort for an additional one-year period with 3 study waves. We will use innovative and rigorous methods, to collect additional data, such as Ecological Momentary Assessment methods and objective measures of cannabis use, PrEP use, and immune function over 14-day periods at each wave. Potential findings can impact intervention development and implementation, as well as inform policy to increase PrEP uptake and adherence, address substance use, and decrease HIV transmission rates, and disparities.

项目摘要 黑人同性恋，双性恋和其他与男人发生性关系的男人（MSM）面临艾滋病毒的不成比例负担。 在受艾滋病毒（例如黑人MSM）影响的人群中，集中，高覆盖范围的准备可以迅速 降低新的艾滋病毒收购率；但是，它在高危人群中的吸收，尤其是黑人MSM 受到限制。因此，我们建议在黑色MSM队列中急需对PREP进行研究， 包括相关行为的影响，尤其是大麻使用的影响，这在黑色中非常普遍 MSM。关于大麻使用对准备的影响的研究取得了矛盾的结果，但还没有 严格研究黑色MSM。因此，拟议的R01研究将评估横截面和 大麻使用和准备成果（例如使用，依从性）和艾滋病毒之间的纵向关联 使用事件级别和客观生物标志物传播风险（例如生物炎症，性风险行为） HIV阴性黑色SMM中的数据。为了解决这些特定目标，我们将进行网络，并 伊利诺伊州芝加哥的社区（N2）大麻预备研究。我们将关注来自250名HIV阴性参与者 原始的N2队列在另外一年的时间内与3个研究波。我们将使用创新和严格 收集其他数据的方法，例如生态瞬时评估方法和客观 在每个波浪时期，在14天的时间内使用大麻，使用和免疫功能的量度。潜在的 调查结果可能会影响干预的开发和实施，并告知政策以增加PREP 吸收和依从性，解决药物使用，并降低HIV传播率和差异。