The National Couples Health and Time Use Stress Biology Study (NCHAT-BIO): Biobehavioral Pathways to Population Health Disparities in Sexual Minorities

全国夫妻健康和时间使用压力生物学研究 (NCHAT-BIO)：性别少数人口健康差异的生物行为途径

• 批准号: 10742339
• 负责人: Lisa Michelle Christian
• 金额: $ 30.41万
• 依托单位: OHIO STATE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-07-01 至 2025-01-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10742339
• 关键词: 18 year old; Accounting; Acute; Address; Adult; Affect; Age; Age Years; Anxiety; Articulation; Asian population; Asthma; Behavioral; Biological; Biological Assay; Biological Markers; Biology; Black Populations; Blood; C-reactive protein; Cardiovascular Diseases; Cellular Immunity; Chronic; Chronic Disease; Chronic stress; Cohort Studies; Color; Complex; Couples; Data; Data Collection; Databases; Diabetes Mellitus; Diet; Discrimination; Dryness; EBV reactivation from latency; Ethnic Origin; Exercise; Exhibits; Funding; Future; Happiness; Health; Health behavior; Heterosexuals; Human Herpesvirus 4; Immune; Immune system; Immunologic Markers; Impairment; Individual; Inflammation; Interleukin-6; Intervention; Investigation; Knowledge; Latinx population; Lesbian Gay Bisexual; Link; Literature; Malignant Neoplasms; Measures; Mediating; Mental Depression; Methodology; National Institute of Child Health and Human Development; Not Hispanic or Latino; Obesity; Outcome; Participant; Pathway interactions; Pattern; Personal Satisfaction; Population; Psychological Factors; Public Health; Race; Recording of previous events; Reduce health disparities; Reporting; Research; Resources; Risk; Sample Size; Sampling; Sleep disturbances; Spottings; Stigmatization; Stress; Testing; Time Study; United States National Academy of Sciences; Victimization; Violence; Woman; access restrictions; biobehavior; cohort; experience; health disparity; health disparity populations; immune function; immunoregulation; inflammatory marker; internalized stigma; intersectionality; men; microaggression; minority stress; minority stressor; modifiable behavior; mortality; novel; obesity risk; optimism; pandemic disease; risk prediction; sexual identity; sexual minority; sexual minority stress; social stigma; stressor; substance use; time use; virtual

Project Summary Sexual minorities have significantly greater risk for obesity, asthma, diabetes, cardiovascular disease, and some cancers compared to heterosexuals. A key driver of these health disparities is chronic stress related to stigmatization. Compounding this, racial and ethnic sexual minorities have complex intersecting identities and experiences of stress that may exacerbate negative health outcomes relative to non-Hispanic White sexual minorities. Chronic stressors can affect the immune system by both increasing inflammation and impairing cellular immunity, a pattern causally predictive of risk for acute illness, chronic disease, and mortality. Funded by NICHD and fielded during the pandemic, the National Couples’ Health and Time Study (NCHAT) includes 5,157 US adults 18-60 years of age, with oversamples of Black, Latinx, and Asian individuals. With 2,230 (43.2%) identifying as gay, lesbian, bisexual, or other identifies, NCHAT is the only population-representative study with a fully-powered subsample of sexual minorities in the US. Capitalizing on the extraordinary opportunity to address the empirical gap in data on stress biology among sexual minorities, particularly those with intersecting identities, we added a pilot biological data collection (dried blood spots; DBS) to NCHAT to create the NCHAT Stress Biology Study (NCHAT-BIO). Biological data collection is complete, but samples are yet to be assayed. In this R21, we will assay these samples to measure inflammation (interleukin-6, C-reactive protein) and cellular immune function (Epstein-Barr virus reactivation). In a diverse cohort of 763 NCHAT participants, we will address these empirical aims: Aim 1: Delineate differences in immune regulation among sexual minorities versus heterosexuals. Hypothesis: Sexual minorities will exhibit greater inflammation and poorer cellular immune function with differential effects among lesbian, gay, and bisexual women and men. Aim 2: Examine effects of stigma, discrimination, and intersectionality on biomarkers of immune dysregulation within a minority stress framework. Hypotheses: Experiences of stigma and discrimination will predict greater inflammation and poorer cellular immune function with stronger effects among sexual minorities and, in particular, sexual minority participants of color. Aim 3: Identify modifiable behaviors and treatable psychological factors linking stress with immune dysregulation. Hypotheses: Modifiable health behaviors (substance use, exercise, diet) and treatable psychological factors (depression, anxiety, sleep disturbance) will mediate the link between sexual minority stress with immune dysregulation, presenting targets for intervention. NCHAT-BIO offers a uniquely comprehensive and methodologically rigorous investigation of stress biology among sexual minorities in the US, permitting novel tests of mechanisms linking stress and health within a minority stress framework. This R21 will support a future R01 addressing longitudinal changes in stress biology in the NCHAT cohort.

项目摘要 性少数民族对肥胖，哮喘，糖尿病，心血管疾病的风险明显更大， 与异性恋者相比，有些癌症。这些健康分布的主要驱动力是慢性压力相关 污名化。使这种，种族和族裔性少数群体具有复杂的身份 和压力的经历可能会加剧与非西班牙裔白人相对于非西班牙裔白人的负面健康结果 性少数群体。慢性应激源可以通过增加炎症和 损害细胞免疫学，一种模式可以预测急性疾病，慢性疾病和死亡率的风险。 由NICHD资助，并在大流行期间进行了派遣 （NCHAT）包括5,157名18-60岁的美国成年人，示例是黑色，拉丁裔和亚洲人 个人。 NCHAT是2,230（43.2％）识别为同性恋，女同性恋，双性恋或其他识别，是唯一的 在美国，人口代表性的研究与性少数群体的子样本。大写 解决性少数群体压力生物学数据的经验差距的非凡机会， 特别是那些具有相交身份的人，我们添加了一个试验生物学数据收集（干血点； DBS）到NCHAT创建NCHAT应激生物学研究（NCHAT-BIO）。生物数据收集是 完整，但样品尚未得到测定。在此R21中，我们将主张这些样品进行测量 炎症（白介素6，C反应蛋白）和细胞免疫功能（Epstein-Barr病毒重新激活）。 在763名NCHAT参与者组成的潜水员队列中，我们将解决这些经验目标： 目标1：描述性少数群体中免疫调节的差异 异性恋。假设：性少数民族将杀死更大的炎症和较差的细胞免疫 女同性恋，同性恋和双性恋男女之间的作用具有不同的作用。目标2：检查效果 污名，歧视和交叉性在A内生物标志物中的污名和交叉性 少数派压力框架。假设：污名和歧视的经历将预测更大的 炎症和细胞免疫功能较差，性少数族裔的影响更强，在 特别是性少数群体的颜色参与者。目标3：确定可修改的行为和可治疗的行为 将压力与免疫失调联系起来的心理因素。假设：可修改的健康行为 （药物使用，运动，饮食）和可治疗的心理因素（抑郁，焦虑，睡眠障碍）将会 调解性少数族裔压力与免疫失调之间的联系，并提出干预目标。 NCHAT-BIO对压力进行了独特的全面和方法严格的研究 美国性少数群体之间的生物学，允许对压力和健康联系的机制进行新的测试 在少数压力框架内。该R21将支持未来的R01，以解决纵向变化 NCHAT队列中的压力生物学。