Bicoastal Marmoset Breeding Center

双海岸狨猴繁育中心

基本信息

批准号：
10401871
负责人：
XIAOQIN WANG
金额：
$ 109.91万
依托单位：
JOHNS HOPKINS UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2020
资助国家：
美国
起止时间：
2020-07-15 至 2025-05-31
项目状态：
未结题

项目摘要

Project Summary The common marmoset (Callithrix jacchus) has experienced unprecedented growth in research across the United States and is rapidly emerging as a likely keystone biomedical model system in the next chapter of scientific discovery. Over the past decade, the number of marmoset laboratories in the US has quadrupled. There are now over 40 Principal Investigators who use marmoset as the model system in their research. Neuroscience is the primary engine driving marmoset research today, as nearly three quarters of marmoset researchers in the US use this model species to examine molecular, systems or cognitive functions in normal and diseased brains. Although these grassroots have been successfully forged new paths of scientific inquiry using marmosets in the U.S., critical bottlenecks have emerged that threaten to thwart the continued growth of this emerging model system. We propose to establish a Bicoastal Marmoset Breeding center, with two breeding colonies, one on the East Coast at Johns Hopkins University (JHU) and the other on the West Coast at University of California at San Diego (UCSD). The Center aims to produce a large number of marmosets to supply the marmoset research community in the U.S. Because of the non-availability of air transport of NHP in U.S. and prohibitively expensive ground transportation of NHP between the east and west coast, these two breeding colonies are strategically located to support the marmoset community in regions near each colony. We believe such a center is needed to address the national shortage of marmosets in order for the marmoset model to realize its full potential as a keystone species in the next chapter of neuroscience that serves to accelerate the rate of discovery and better understand human neurological disease.

项目概要普通狨猴（Callithrix jacchus）的研究经历了前所未有的增长美国，并正在迅速崛起，成为下一章可能的基石生物医学模型系统科学发现。过去十年，美国狨猴实验室的数量增加了四倍。目前已有 40 多名首席研究员在研究中使用狨猴作为模型系统。神经科学是当今推动狨猴研究的主要引擎，因为近四分之三的狨猴美国的研究人员使用这种模式物种来检查正常情况下的分子、系统或认知功能和患病的大脑。尽管这些草根阶层已经成功地开辟了科学探究的新路径在美国使用狨猴时，出现了严重的瓶颈，有可能阻碍狨猴的持续增长这个新兴的模型系统。我们建议建立一个双海岸狨猴繁育中心，拥有两个繁殖地，一个位于东海岸的约翰·霍普金斯大学 (JHU)，另一个位于西海岸在加州大学圣地亚哥分校（UCSD）。该中心的目标是培育大量狨猴供应美国狨猴研究界，因为在美国没有 NHP 航空运输美国和 NHP 东海岸和西海岸之间极其昂贵的地面运输，这两个繁殖地的地理位置具有战略意义，以支持每个繁殖地附近地区的狨猴群落。我们认为需要这样一个中心来解决全国狨猴短缺的问题，以便狨猴模型以充分发挥其作为神经科学下一章关键物种的潜力，这有助于加快发现速度并更好地了解人类神经系统疾病。