Bicoastal Marmoset Breeding Center

双海岸狨猴繁育中心

• 批准号: 10289057
• 负责人: XIAOQIN WANG
• 金额: $ 29.82万
• 依托单位: JOHNS HOPKINS UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-06-01 至 2022-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10289057
• 关键词: Administrative Supplement; Age; Age-Years; Aging; Alzheimer' s Disease; Alzheimer' s disease model; Alzheimer’s disease biomarker; Amyloidosis; Anatomy; Animal Model; Animals; Award; Biological Models; Biomedical Research; Brain; Breeding; Callithrix; Callithrix jacchus jacchus; Communities; Country; Dementia; Disease; Funding; Goals; Housing; Human; Longevity; Modeling; Parents; Physiological; Pilot Projects; Primates; Request for Applications; Research; Research Personnel; Resource Development; Resources; Source; United States National Institutes of Health; Work; age related; gene interaction; human old age (65+); nonhuman primate; offspring; programs; public health relevance; response

Nonhuman primates (NHP) are crucial animal models for research on Alzheimer’s disease and its related dementias because of their closest evolutionary relatives of humans, with whom they share anatomical, physiological, and gene interactions features. The common marmoset (Callithrix jacchus) is a NHP model of increasing importance for aging research. This new world primate provides some unique advantages for the study of aging and aging-related disorders, including its relatively short lifespan among all the NHP used in biomedical research. There has been an increasing number of investigators who are currently using or would like to use marmosets as a model system to study aging and age-related diseases including Alzheimer’s disease. However, there is a significant bottleneck for the research in this field. There are currently no reliable distributors of marmosets for biomedical research in the country. The situation is even direr for researchers who need access to aging marmosets. Recognizing such a bottleneck, NIH has recently funded two marmoset breeding programs including the parent award of this application (“Bicoastal Marmoset Breeding Center”, U24- MH123423). The goal of the proposed project is to fill the gap in the availability of aging marmosets for the study of Alzheimer’s disease and its related dementias. We could use this center to develop a resource of aging marmosets for Alzheimer's disease studies. This resource will be extremely valuable to the scientific community studying Alzheimer's disease and its related dementias.

非人灵长类动物（NHP）是研究阿尔茨海默病及其相关疾病的重要动物模型 痴呆症是因为它们在进化上与人类关系最近，与人类有共同的解剖学特征， 普通狨猴 (Callithrix jacchus) 是 NHP 模型。 这种新世界灵长类动物为衰老研究提供了一些独特的优势。 衰老和衰老相关疾病的研究，包括其在所有 NHP 中相对较短的寿命 越来越多的研究人员正在使用或将要使用。 喜欢使用狨猴作为模型系统来研究衰老和与年龄相关的疾病，包括阿尔茨海默病 然而，目前该领域的研究存在重大瓶颈。 该国用于生物医学研究的狨猴经销商的情况对于研究人员来说更加严峻。 认识到这一瓶颈，美国国立卫生研究院最近资助了两只狨猴。 育种计划，包括本申请的家长奖（“双海岸狨猴育种中心”，U24- MH123423) 拟议项目的目标是填补老龄狨猴的供应空白。 我们可以利用这个中心来开发阿尔茨海默病及其相关痴呆症的资源。 用于阿尔茨海默病研究的衰老狨猴这一资源对于科学界来说非常有价值。 研究阿尔茨海默病及其相关痴呆症的社区。