PFAS Exposure and Health Effects in El Paso County, Colorado

科罗拉多州埃尔帕索县的 PFAS 暴露和健康影响

• 批准号: 10220758
• 负责人: JOHN L. ADGATE
• 金额: $ 100万
• 依托单位: UNIVERSITY OF COLORADO DENVER
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-09-30 至 2024-09-29
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10220758
• 关键词: PFAS; Exposure; Health; Effects; El

Project Summary/Abstract The overall goal of this research is to quantify the cross-sectional associations between measured and modeled perfluoroalkyl and polyfluoroalkyl substances (PFAS) in highly exposed adults and children and selected health outcomes, including lipids, kidney function, liver function, thyroid hormones and sex hormones, glucose and insulin parameters, markers of immune function, and neurobehavioral outcomes in children. We will enroll 1,000 adults and 400 children from a community in El Paso County, Colorado who experienced high levels of PFAS contamination of their municipal drinking water and private wells resulting from the use of aqueous film-forming foams (AFFF) for firefighting activities at a nearly US Air Force Base. Exposure to PFAS will be assessed via measured serum concentrations and through a detailed model to reconstruct historical PFAS concentrations in groundwater and drinking water in El Paso County. Combining this information with individual residential histories, we will be able to estimate cumulative lifetime exposure to AFFF-related PFAS in El Paso County for each study participant. Our research team is well qualified to achieve this goal due to our complementary expertise in exposure science (Adgate), environmental epidemiology (Starling), PFAS chemistry and drinking water exposure (Higgins, Vestergren), groundwater modeling (Singha, McCray), neurobehavioral testing (Wilkening), cancer epidemiology (Cockburn), statistical methods for the analysis of observational data (Glueck), and community outreach and education (Richardson, Celico). We have conducted a pilot study in El Paso County that demonstrates the feasibility of recruiting participants to complete study procedures similar to those in the ATSDR protocol. The preliminary results of our pilot study show: (1) a unique AFFF-related exposure profile with median concentrations of perfluorohexane sulfonate (PFHxS) more than ten times the median of the general US population, and (2) prominent differences in AFFF-related PFAS exposure by geographic area with an apparent north-south gradient in serum concentrations within El Paso County. In addition to the common core protocol, we propose two investigator-initiated aims: (1) a highly innovative examination of the association between PFAS and biomarkers linked to testicular and thyroid cancer risk (both previously identified in human and animal studies as potentially related to PFAS exposure), and (2) the application of novel statistical methods to estimate the combined effect of exposure to the complex mixture of PFAS found in AFFF-contaminated drinking water, and to separate the effects of individual PFAS from the correlated mixture. This research fills an important knowledge gap because populations in numerous US states have been exposed to AFFF-derived PFAS via contaminated drinking water. The completion of these aims will provide essential information for communities, researchers, and policymakers seeking to understand the health risks associated with this emerging PFAS exposure profile.

项目概要/摘要 这项研究的总体目标是量化测量和测量之间的横截面关联 对高度暴露的成人和儿童中的全氟烷基和多氟烷基物质 (PFAS) 进行建模， 选定的健康结果，包括血脂、肾功能、肝功能、甲状腺激素和性激素， 儿童的葡萄糖和胰岛素参数、免疫功能标志物和神经行为结果。我们 将招募来自科罗拉多州埃尔帕索县一个社区的 1,000 名成人和 400 名儿童，这些儿童曾经历过高血压 由于使用 水成膜泡沫 (AFFF) 用于美国空军基地附近的消防活动。接触 PFAS 将通过测量的血清浓度进行评估，并通过详细的模型来重建历史 埃尔帕索县地下水和饮用水中的 PFAS 浓度。将此信息与 个人居住史，我们将能够估计一生中累积的 AFFF 相关 PFAS 暴露 埃尔帕索县的每位研究参与者。我们的研究团队完全有资格实现这一目标，因为我们 暴露科学 (Adgate)、环境流行病学 (Starling)、PFAS 方面的补充专业知识 化学和饮用水暴露（Higgins、Vestergren）、地下水模拟（Singha、McCray）、 神经行为测试（Wilkening）、癌症流​​行病学（Cockburn）、分析统计方法 观察数据（Glueck）以及社区外展和教育（Richardson、Celico）。我们进行了 埃尔帕索县的一项试点研究证明了招募参与者完成研究的可行性 程序类似于 ATSDR 协议中的程序。我们的试点研究的初步结果表明：（1）独特的 与 AFFF 相关的暴露曲线，全氟己烷磺酸盐 (PFHxS) 的中值浓度超过 是美国普通人口中位数的十倍，以及 (2) AFFF 相关 PFAS 存在显着差异 埃尔帕索内按地理区域暴露的血清浓度存在明显的南北梯度 县。除了共同的核心协议之外，我们还提出了两个研究者发起的目标：（1）高度 对 PFAS 与睾丸和甲状腺相关生物标志物之间关联的创新检查 癌症风险（之前在人类和动物研究中发现可能与 PFAS 暴露相关）， (2) 应用新的统计方法来估计暴露于复合物的综合效应 AFFF 污染的饮用水中发现的 PFAS 混合物，并分离单个 PFAS 的影响 从相关混合物中。这项研究填补了一个重要的知识空白，因为许多人口 美国各州已通过受污染的饮用水接触到水成膜纤维衍生的 PFAS。完成 这些目标将为寻求以下目标的社区、研究人员和政策制定者提供重要信息： 了解与这种新兴 PFAS 暴露状况相关的健康风险。