GENOMICS

基因组学

• 批准号: 7714262
• 负责人: Thomas Conrad GILLIAM
• 金额: $ 27.23万
• 依托单位: UNIVERSITY OF CHICAGO
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-07-22 至 2013-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7714262
• 关键词: Area; Arts; Awareness; Bioinformatics; Biological Sciences; Clinical; Computer software; Confidentiality; Core Facility; DNA Sequence; DNA Sequencing Facility; Data; Data Analyses; Data Set; Data Storage and Retrieval; Databases; Detection; Ensure; Future; Genes; Genetic; Genome; Genomics; Genotype; Goals; Health Insurance Portability and Accountability Act; Housing; Individual; Laboratories; Peer Review; Phenotype; Research; Research Infrastructure; Research Personnel; Resources; Services; Solutions; Speed; Standards of Weights and Measures; Technology; University of Chicago Cancer Research Center; anticancer research; base; biomedical informatics; data acquisition; functional genomics; interdisciplinary collaboration; programs; quality assurance

The Genomics Core Facility (GCF) was created in 2006 by combining two existing institutional cores - the UCCRC-supported DNA Sequencing and Genotyping Facility and the Functional Genomics Facility - with the genomics-related bioinformatics services previously provided by the developing Biomedical Informatics Facility. These resources have become so integral to cutting-edge research in the biological sciences that essentially every laboratory-based investigator in the UCCRC will access them on a regular basis. While these facilities have previously operated independently, their functions overlap in complementary and necessary ways. The merger into a single, integrated Core, a task that will be completed with co-localization in dedicated space in the Knapp Center for Biomedical Discovery (KCBD; a new building which will be completed in 2008), will result in significant benefit to investigators. Over 82 peer-reviewed UCCRC investigators across all six Scientific Programs routinely use the combined Functional Genomics and DNA Sequencing and Genotyping Facilities, representing 44% of Facility usage. The Facility provides state-of-the-art microarray, DNA sequencing, and genotyping platforms with specialized databases for storing, managing, and manipulating both clinical information (phenotypes) and diverse types of genetic and genomic data (genotypes). Expert assistance in the detection technologies, as well as adapting the resulting data to modern database solutions using high-speed specialized hardware and sophisticated commercial and academic software tailored for genomics and bioinformatics research will provide UCCRC investigators who use the GCF the highest standards of data acquisition, protection, confidentiality, and HIPAA compliance currently available to academic researchers. The GCF is aimed towards biomedical researchers who are generally unfamiliar with whole genome and bioinformatics approaches, as well as experts seeking more sophisticated hardware, software, programming, or database solutions, or seeking to facilitate interdisciplinary collaborations. Major goals of the GCF are to provide investigators with scientific and technical staff who can assist with or collaborate on individual projects, provide an educational program that allows investigators to seek their own levels of expertise and sophistication in a given application, and raise awareness of new directions and major discoveries in the areas of genomics and bioinformatics.

基因组学核心设施（GCF）是通过结合了两个现有机构核心而创建的。 UCCRC支持的DNA测序和基因分型设施以及功能基因组学设施 - 与基因组相关的生物信息学服务先前由开发生物医学提供 信息设施。这些资源已成为生物学的尖端研究的重要组成部分 从本质上讲，UCCRC中每个基于实验室的研究者的科学都会定期访问它们 基础。尽管这些设施以前已经独立运营，但它们的功能重叠 互补和必要的方法。合并成一个单一的集成核心，这将是 在KNAPP生物医学发现中心（KCBD; 将于2008年完成的新建筑物将为调查人员带来重大好处。超过82 经过同行评审的UCCRC调查人员在所有六个科学计划中通常使用合并 功能性基因组学和DNA测序和基因分型设施，代表44％的设施 用法。 该设施提供了最先进的微阵列，DNA测序和基因分型平台，并提供 用于存储，管理和操纵临床信息（表型）和 各种类型的遗传和基因组数据（基因型）。检测技术方面的专家协助， 以及使用高速专业的数据将结果数据调整为现代数据库解决方案 硬件以及针对基因组学和生物信息学量身定制的精致商业和学术软件 研究将为UCCRC调查人员提供使用GCF最高数据获取标准的研究人员， 目前，学术研究人员可以使用保护，机密性和HIPAA合规性。 GCF针对的是生物医学研究人员，他们通常不熟悉整个基因组和 生物信息学方法以及寻求更复杂的硬件，软件， 编程或数据库解决方案，或寻求促进跨学科的合作。主要目标 GCF的旨在为调查人员提供可以协助或 在单个项目上合作，提供一个教育计划，使调查人员可以寻求他们的 在给定应用中的自己的专业知识和精致水平，并提高对新方向的认识 以及基因组学和生物信息学领域的主要发现。