Gene-Enviroment Interaction in Cognition

认知中的基因-环境相互作用

• 批准号: 6743401
• 负责人: Thomas Conrad GILLIAM
• 金额: $ 14.51万
• 依托单位: COLUMBIA UNIVERSITY HEALTH SCIENCES
• 依托单位国家: 美国
• 财政年份: 2003
• 资助国家: 美国
• 起止时间: 2003-09-30 至 2005-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6743401
• 关键词: South American; behavioral /social science research tag; behavioral genetics; biomarker; catechol methyltransferase; clinical research; cooperative study; coping; dementia; environmental exposure; gene environment interaction; human subject; international cooperation; mental health services; short term memory; social adjustment; socioenvironment

DESCRIPTION (provided by applicant): We propose a collaborative effort between Columbia University (CU) and University of Zulia (LUZ), Maracaibo-Venezuela, to investigate the effects of life conditions and environmental exposures together with genetic factors upon the expression of specific cognitive abilities. We aim to strengthen the capacity of Venezuelan scientists to design and execute research centered on cognitive impairment from birth to advanced age, with emphasis in disorders common in the State of Zulia; including Alzheimer's disease, Huntington's disease and Vascular Dementia. We propose the following specific aims for this exploratory project: 1. To assess the social impact of dementias in the State of Zulia. We will conduct a qualitative ethnographic study among family and caregivers of demented patients, as well as among primary care health professionals, identifying beliefs about cognitive impairment, dementia, knowledge, impact of disease on family life, self esteem, family identity, social reactions, access to health care and quality of care by professionals. 2. To assess current resources and needs and develop and initiate a plan to address these needs to promote the successful conduct of the proposed research and capacity building. 3. To show feasibility and generate preliminary data to justify submission of collaborative research via an R01 grant mechanism and to identify specific research questions that show the greatest promise for advancement. We will test whether a catecoI-O-methyltransferase (COMT) gene variant affects working memory and executive function in Venezuelan families segregating subcortical white matter hyperintensities. Variance accounted for by the gene variant and life conditions and environmental exposures will be examined. 4. To identify training and other capacity-building opportunities in the context of brain health promotion throughout life. At the end of the planning period, we hope to have initiated preliminary studies and to have organized, planned, prepared and assembled an application for a more comprehensive R01 grant involving collaboration between CU and LUZ investigators incorporating both research and capacity building.

描述（由申请人提供）：我们提出了哥伦比亚大学（CU）和Zulia大学（LUZ）（Maracaibo-Venezuela）之间的合作努力，以研究生活条件和环境暴露的影响以及遗传因素对特定认知能力的表达。 我们旨在加强委内瑞拉科学家设计和执行以认知障碍为中心的研究和执行研究的能力，重点是祖利亚州常见的疾病；包括阿尔茨海默氏病，亨廷顿氏病和血管痴呆。 我们提出了以下针对此探索性项目的具体目标：1。评估痴呆症对祖利亚州的社会影响。 我们将对痴呆症患者以及初级保健专业人员的家庭和护理人员进行定性民族志研究，以确定对认知障碍，痴呆，知识，疾病对家庭生活的影响，自尊心，家庭认同，社会认同，社会反应，获得医疗保健和护理质量的信念。 2。评估当前的资源和需求，并制定并启动计划，以解决这些需求，以促进拟议的研究和能力建设的成功行为。 3。显示可行性并生成初步数据，以证明通过R01赠款机制提交协作研究的合理性，并确定特定的研究问题，这些问题显示出最大的进步前景。 我们将测试Catecoi-O-甲基转移酶（COMT）基因变体是否会影响委内瑞拉家族的工作记忆和执行功能。 将检查由基因变体和生命状况和环境暴露的差异。 4。在一生中促进大脑健康的背景下，确定培训和其他能力建设机会。 在计划期结束时，我们希望能够启动初步研究，并组织，计划，准备和组装申请，以涉及CU和LUZ调查人员之间合作的更全面的R01赠款，以纳入研究和能力建设。