Characterizing Communicating Genetic Risk Alzheimer's

表征传播遗传风险阿尔茨海默病

• 批准号: 7211279
• 负责人: Robert C. Green
• 金额: $ 17.56万
• 依托单位: BOSTON UNIVERSITY MEDICAL CAMPUS
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-09-30 至 2011-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7211279
• 关键词: African American; Alzheimer' s disease; anxiety; apolipoprotein E; behavioral /social science research tag; biotechnology; cardiovascular disorder risk; caucasian American; clinical research; depression; family genetics; gene interaction; genetic counseling; genetic screening; genetic susceptibility; health services research tag; high throughput technology; human genetic material tag; human subject; patient oriented research; racial /ethnic difference; single nucleotide polymorphism

DESCRIPTION (provided by applicant): This is an application for a K24 Midcareer Investigator Award in patient-oriented research. The candidate is a professor of neurology and epidemiology at the Boston University with an established record as a researcher, clinician, and educator. The proposed mentoring and research plans are focused on two major themes: (1) discovering and quantifying ways of characterizing genetic risk for Alzheimer's disease and (2) creating and evaluating real-world procedures for communicating genetic risk. The Mentoring Plan takes advantage of the candidate's experiences and position as director of a large and diverse program in patient-oriented research with Alzheimer's disease patients and their families. Under the supervision of the K24 awardee, each trainee will develop and carry out independent research projects from design to publication. Trainees will obtain hands-on experience in multiple aspects of patient-oriented research including focus group and survey development, small and large scale clinical trials, and epidemiological studies. Trainees will participate in research seminars, methodology and grant-writing workshops, meetings on multidisciplinary consensus conferences and in the ongoing K30 Clinical Research Curriculum at BU. Funding for statistical consultation will assure that biostatistical support is readily available. Formal coursework at the BU School of Public Health will be encouraged. In all activities, trainees will follow a detailed mentoring plan with a schedule of structured activities, and with clear roles, specific responsibilities and concrete evaluation plans measuring knowledge, skill and productivity. The Research Plan builds upon two large funded R01 projects, the Multi-Institutional Research in Alzheimer's Genetic Epidemiology (MIRAGE) Study and the Risk Evaluation and Education for Alzheimer's Disease (REVEAL) Study. Each of these studies has been competitively renewed at least once, and has extensive ongoing operations and data available for trainee education and analysis of data. This award will also help refine the candidate's own research skills in the area of genetic epidemiology and lay the groundwork for expanding the MIRAGE Study and the REVEAL Study in new directions.

描述（由申请人提供）：这是一份针对以患者为导向的研究领域的 K24 职业生涯中期研究者奖的申请。该候选人是波士顿大学神经病学和流行病学教授，具有作为研究员、临床医生和教育家的良好记录。拟议的指导和研究计划重点关注两个主题：(1) 发现和量化表征阿尔茨海默病遗传风险的方法；(2) 创建和评估用于传达遗传风险的现实程序。指导计划利用了候选人作为阿尔茨海默病患者及其家人以患者为导向的研究的大型多元化项目主任的经验和职位。在K24获奖者的监督下，每位学员将开发并开展从设计到出版的独立研究项目。学员将获得以患者为中心的研究多个方面的实践经验，包括焦点小组和调查开发、小型和大规​​模临床试验以及流行病学研究。学员将参加研究研讨会、方法论和资助写作研讨会、多学科共识会议以及波士顿大学正在进行的 K30 临床研究课程。统计咨询资金将确保生物统计支持随时可用。鼓励在波士顿大学公共卫生学院开设正式课程。在所有活动中，学员将遵循详细的指导计划，其中包括结构化活动时间表，并具有明确的角色、具体职责和衡量知识、技能和生产力的具体评估计划。该研究计划以两个大型资助的 R01 项目为基础，即阿尔茨海默病遗传流行病学多机构研究 (MIRAGE) 和阿尔茨海默病风险评估和教育 (REVEAL) 研究。这些研究中的每一项都至少更新了一次，并且拥有广泛的持续操作和数据可用于学员教育和数据分析。该奖项还将有助于提高候选人自身在遗传流行病学领域的研究技能，并为扩展 MIRAGE 研究和 REVEAL 研究的新方向奠定基础。