Genetics of Common Heritable Disorders in Venezuela

委内瑞拉常见遗传性疾病的遗传学

基本信息

批准号：
7126007
负责人：
Thomas Conrad GILLIAM
金额：
$ 36.62万
依托单位：
UNIVERSITY OF CHICAGO
依托单位国家：
美国
项目类别：
财政年份：
2002
资助国家：
美国
起止时间：
2002-09-20 至 2010-08-31
项目状态：
已结题

项目摘要

DESCRIPTION (provided by applicant): The goal of the proposed research-training program is to strengthen the capacity of Venezuelan scientists based at the University of Zulia to study genetics of common hereditable disorders relevant to Latin America and the Caribbean, and in particular to Venezuela. The strategy is to enhance the current research and training programs at the University of Zulia by: (1) training a critical mass of scientists and engineers in the design and conduct of modern genetic/genomic research (2) facilitating the development of a research and training infrastructure at the University of Zulia that will draw upon and focus clinical and scientific expertise throughout Western Venezuela (3) sustaining the research and training programs at the University of Zulia by establishing collaborative networks with Columbia University researchers studying the genetic basis of the most common complex hereditable disorders. The proposed training program seeks to capitalize upon current genetic and genomic research programs at Columbia University that overlap thematically with the focus on common heritable neurodegenerative disorders at the University of Zulia. The training program is designed to educate doctoral students and postdoctoral fellows in human genetics, including genetic epidemiology, population genetics, molecular genetics, clinical genetics, statistical genetics and bioinformatics, with a broad understanding on the ethical, legal and social issues related to human genetics research. The didactic component of the program includes a series of academic courses, seminars and laboratory rotations. In the research component each Fellow will work closely with a Preceptor on an independent research project of the Fellow's choosing and that is related to his/her future research in Venezuela. In addition Fellows will be exposed to the process of development of low-cost diagnostic methods that may facilitate the recognition of neurodegenerative disorders and the development of preventive or ameliorative treatment options. At the end of the program Fellows should understand the critical aspects of study design, methodology, and genetic and epidemiological theory relevant to the detection of complex disease loci and to specifically address the interaction of genetic factors with environmental and cultural factors. Emphasis will be given to defining tractable genetic targets and building productive collaborations.

描述（由申请人提供）：拟议的研究培训计划的目的是增强祖利亚大学委内瑞拉科学家的能力，以研究与拉丁美洲和加勒比海尤其与委内瑞拉有关的常见可遗传性疾病的遗传学。该策略是通过：（1）在现代遗传/基因组研究的设计和行为上培训一大批科学家和工程师在祖里亚大学的当前研究和培训计划（2）培训Zulia大学的研究和培训基础设施的发展，这些研究和培训基础设施将在整个Vential和Sciential posentific of Posentical of Posential and Scoriessization posential和Sciential posentific of Clinatial and Scoriessization national native of Scunsigation and native of Stroce Instruction newertialickia（3）培训（3）培训（3）研究，并培训了维纳泽尔（3）的研究（3）与哥伦比亚大学研究人员的网络研究最常见的复杂遗传性疾病的遗传基础。拟议的培训计划旨在利用哥伦比亚大学当前的遗传和基因组研究计划，其主题重叠，重点是祖利亚大学的常见可遗传神经退行性疾病。该培训计划旨在在人类遗传学中教育博士生和博士后研究员，包括遗传流行病学，人群遗传学，分子遗传学，临床遗传学，统计遗传学和生物信息学，对与人类遗传学有关的道德，法律和社会问题有广泛的了解。该计划的教学组成部分包括一系列学术课程，研讨会和实验室轮换。在研究组件中，每个研究员将与该同伴选择的独立研究项目的主持人紧密合作，这与他/她未来在委内瑞拉的研究有关。另外，研究员将暴露于低成本诊断方法的发展过程，这些方法可能有助于识别神经退行性疾病以及预防或改善治疗方案的发展。在计划结束时，研究员应了解与检测复杂疾病基因座有关的研究设计，方法论以及遗传学和流行病学理论的关键方面，并专门解决遗传因素与环境和文化因素的相互作用。将重点放在定义可进行的遗传目标和建立富有成效的合作方面。

项目成果

期刊论文数量（2）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Sonic hedgehog maintains cellular and neurochemical homeostasis in the adult nigrostriatal circuit.

DOI：
10.1016/j.neuron.2012.05.018
发表时间：
2012-07-26
期刊：
Neuron
影响因子：
16.2
作者：
Gonzalez-Reyes LE;Verbitsky M;Blesa J;Jackson-Lewis V;Paredes D;Tillack K;Phani S;Kramer ER;Przedborski S;Kottmann AH
通讯作者：
Kottmann AH