P30 - Core Grant For Vision Research

P30 - 视觉研究核心资助

• 批准号: 7616514
• 负责人: Eric Pearlman
• 金额: $ 64.46万
• 依托单位: CASE WESTERN RESERVE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1998
• 资助国家: 美国
• 起止时间: 1998-04-01 至 2012-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7616514
• 关键词: P30; Core; Grant; Vision; Research

DESCRIPTION: This application is for the renewal of an NEI Core Grant in support of the research programs of 16 principal investigators holding 23 active NEI individual research grants and an NEI Institutional Training grant. The previous funding cycle generated 100 publications in the major areas of aging and diabetes, extraocular muscle biology and diseases, ocular immunology and inflammation, and retinal biology and diseases. The current investigators form the nucleus of the Case Visual Sciences Research Center (VSRC), a broader group of 40 vision researchers in 19 different basic and clinical science departments at the Case Medical Center (Case Western Reserve University School of Medicine and University Hospitals of Cleveland). Since our initial Core Grant award in 1997 and its renewal in 2002 with five Modules, these modules have continued to evolve over the current funding cycle due to a changing investigator group and scientific direction, expanded services and new technologies. The five modules that are proposed are: 1) Tissue Culture and Hybridoma, 2) Histology, Microscopy and Imaging, 3) Molecular Biology, 4) Specialized Animal Resource, and 5) Proteomics. Major new functions since our previous submission include hybridoma production, live cell imaging, laser capture microdissection, and a full service proteomics facility to acquire and analyze protein expression in ocular tissues. With the recent renewal of the T32 Training grant, these modules will also continue to serve as an integral resource for pre- and postdoctoral trainees in the Case Visual Sciences Training Program. The Visual Sciences at Case has receives very strong institutional support, including, construction of a centralized facility for Core Grant modules and functions, recruitment funds and supplemental support for technical salaries and supplies in the core facilities. The change in P.I. from Dr. Lass to Dr. Pearlman will ensure continuity in leadership and direction of the Core Grant, which will enable collaborative goals and objectives while enhancing individual programs, and facilitate Case VSRC investigators' continuing efforts toward analysis of fundamental mechanisms in ocular and visual system development, function, and pathogenesis of diseases of the eye and visual system.

描述：本申请用于更新 NEI 核心补助金，以支持 16 名主要研究者的研究项目，这些研究人员持有 23 项活跃的 NEI 个人研究补助金和 NEI 机构培训补助金。上一个资助周期产生了 100 篇出版物，涉及衰老和糖尿病、眼外肌生物学和疾病、眼部免疫学和炎症以及视网膜生物学和疾病等主要领域。目前的研究人员构成了凯斯视觉科学研究中心 (VSRC) 的核心，该中心由凯斯医学中心（凯斯西储大学医学院和克利夫兰大学医院）19 个不同基础和临床科学部门的 40 名视觉研究人员组成。 ）。自我们于 1997 年首次获得核心资助金并于 2002 年更新了五个模块以来，由于研究小组和科学方向的变化、服务的扩展和新技术的出现，这些模块在当前的资助周期中不断发展。提议的五个模块是：1) 组织培养和杂交瘤，2) 组织学、显微镜和成像，3) 分子生物学，4) 专业动物资源，以及 5) 蛋白质组学。自我们上次提交以来的主要新功能包括杂交瘤生产、活细胞成像、激光捕获显微切割以及用于获取和分析眼组织中蛋白质表达的全方位服务蛋白质组学设施。随着最近 T32 培训补助金的续签，这些模块也将继续作为案例视觉科学培训计划中博士前和博士后学员的不可或缺的资源。凯斯视觉科学学院得到了非常强大的机构支持，包括为核心拨款模块和功能建设集中设施、招聘资金以及核心设施中技术工资和用品的补充支持。 P.I. 的变化从 Lass 博士到 Pearlman 博士将确保核心拨款的领导和方向的连续性，这将在加强个人项目的同时实现协作目标和目标，并促进 Case VSRC 调查人员继续努力分析眼部和视觉系统的基本机制眼睛和视觉系统疾病的发育、功能和发病机制。