University of California San Diego Neuroscience Microscopy Imaging Core

加州大学圣地亚哥分校神经科学显微成像核心

• 批准号: 10524688
• 负责人: JOSEPH G GLEESON
• 金额: $ 15.64万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN DIEGO
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-12-01 至 2022-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10524688
• 关键词: Administrative Supplement; Award; Books; California; Cancer Grant Supplements (P30); Center Core Grants; Communities; Consult; Core Facility; Country; Faculty; Funding; Funding Agency; Funding Mechanisms; Future; Goals; Grant; Hour; Human Resources; Imaging Device; Income; Interruption; Investments; Knowledge; Microscopy; Mission; National Institute of Neurological Disorders and Stroke; Nervous system structure; Neurosciences; Neurosciences Research; Painless; Provider; Publications; Reporting; Research; Research Personnel; Resources; Role; Services; Source; Time; United States National Institutes of Health; Universities; Vendor; base; cost; instrument; light microscopy; medical schools; microscopic imaging; nervous system disorder; operation; pandemic disease; programs; ranpirnase; repaired; success; tool

PROJECT SUMMARY / ABSTRACT The Neuroscience Microscopy Imaging Core at the UCSD School of Medicine has been fortunate to be funded continuously by the NINDS P30 program during the program’s existence from 2003 to 2021. NINDS has decided to sunset the program and this P30 grant is no longer renewable. P30 funding in the past 18 years has been instrumental in supporting the building of a world class microscopy facility that serves the microscopy imaging needs of our excellent research programs funded by NINDS, NIH, and other federal funding agencies across the entire UCSD campus. We have over 100 active user labs at any given time, with >40 labs funded by NINDS. Focusing on one type of tools in serving a large user base allows our core to operate with great efficiency. Our core is leading among the 25 or so NINDS funded P30 centers around the country in the number of supported publications. The funding of our core was considered a best value for shared facility funding in programmatic reviews. As our core transitions into a post-P30 era, we will continue to strive to meet the microscopy imaging needs of our faculty by seeking alternative funding sources, leveraging vendor relations and institutional support. We have already started to make efforts on these fronts. Nevertheless, this transition will not be painless, as resources supported by the P30 are not easily replaceable. To ease this transition and to provide a bridge to the future, we request an end-of-the-grant-cycle P30 supplement to provide a cushion so that resources previously provided by P30 will be gradually replaced by other means in the next year. This supplement will be used to support personnel, instrument repair and supplies during this transition period. We thank the NINDS for considering this supplement and for providing the P30 funding mechanisms for the past 18 years. In future, our core will continue to support the mission of the NINDS by serving a wide range of outstanding research programs that aim to gain fundamental knowledge of the nervous system and to reduce the burden of neurological diseases.

项目摘要 /摘要 UCSD医学院的神经科学显微镜成像核心很幸运 该计划从2003年到2021年，NINDS P30计划不断。 为了日落，该P30赠款不再可续签。过去18年中的P30资金已经 为支持显微镜成像的世界一流的显微镜设施的建设提供了帮助 由Ninds，NIH和其他联邦资助机构资助的优秀研究计划的需求 整个UCSD校园。在任何给定时间，我们都有100多个活跃的用户实验室，> 40个由Ninds资助的实验室。 专注于为大型用户群服务的一种工具，使我们的核心能够以极大的效率运行。我们的 Core在全国各地的25个左右资助的P30中心中处于领先地位。 出版物。我们核心的资金被认为是编程共享设施资金的最佳价值 评论。随着我们向P30后时代的核心过渡，我们将继续努力满足显微镜成像 通过寻求替代资金来源，利用供应商关系和机构支持，我们教师的需求。 我们已经开始在这些方面努力。然而，这种过渡不会痛苦，因为 P30支持的资源不容易更换。缓解这种过渡并提供通往桥梁的桥梁 未来，我们要求提供赠款循环P30补充剂以提供垫子，以便以前资源 由P30提供的明年将逐渐用其他手段代替。该补充剂将用于 在此过渡期间，支持人员，仪器维修和供应。我们感谢Ninds 考虑到这种补充并提供过去18年的P30资金机制。将来，我们的 核心将继续通过服务广泛的杰出研究计划来支持NIND的使命 这目的是获得对神经系统的基本知识并减少神经系统疾病的燃烧。

项目成果

Low-density lipoprotein receptor related protein-1 (LRP1)-dependent cell signaling promotes neurotrophic activity in embryonic sensory neurons.

低密度脂蛋白受体相关蛋白 1 (LRP1) 依赖性细胞信号传导可促进胚胎感觉神经元的神经营养活性。

• DOI: 10.1371/journal.pone.0075497
• 发表时间: 2013
• 期刊: PloS one
• 影响因子: 3.7
• 作者: Yamauchi,Kazuyo;Yamauchi,Tomonori;Mantuano,Elisabetta;Murakami,Kenichi;Henry,Kenneth;Takahashi,Kazuhisa;Campana,WendyMarie
• 通讯作者: Campana,WendyMarie

Chronic thromboembolic pulmonary hypertension-associated dysfibrinogenemias exhibit disorganized fibrin structure.

慢性血栓栓塞性肺动脉高压相关的异常纤维蛋白原血症表现出纤维蛋白结构紊乱。

• DOI: 10.1016/j.thromres.2013.09.024
• 发表时间: 2013
• 期刊: Thrombosis research
• 影响因子: 7.5
• 作者: Marsh,JamesJ;Chiles,PeterG;Liang,Ni-Cheng;Morris,TimothyA
• 通讯作者: Morris,TimothyA

Insulin/PI3K signaling protects dentate neurons from oxygen-glucose deprivation in organotypic slice cultures.

• DOI: 10.1111/j.1471-4159.2009.06450.x
• 发表时间: 2010-01
• 期刊: Journal of neurochemistry
• 影响因子: 4.7
• 作者: Sun X;Yao H;Douglas RM;Gu XQ;Wang J;Haddad GG
• 通讯作者: Haddad GG

Analysis of the initiation of nuclear pore assembly by ectopically targeting nucleoporins to chromatin.

• DOI: 10.1080/19491034.2015.1004260
• 发表时间: 2015
• 期刊: Nucleus (Austin, Tex.)
• 作者: Schwartz M;Travesa A;Martell SW;Forbes DJ
• 通讯作者: Forbes DJ

p300 or CBP is required for insulin-stimulated glucose uptake in skeletal muscle and adipocytes.

• DOI: 10.1172/jci.insight.141344
• 发表时间: 2022-01-11
• 期刊: JCI insight
• 影响因子: 8
• 作者: Martins VF;LaBarge SA;Stanley A;Svensson K;Hung CW;Keinan O;Ciaraldi TP;Banoian D;Park JE;Ha C;Hetrick B;Meyer GA;Philp A;David LL;Henry RR;Aslan JE;Saltiel AR;McCurdy CE;Schenk S
• 通讯作者: Schenk S