Bioinformatics/Biostatistical Core

生物信息学/生物统计核心

• 批准号: 7677526
• 负责人: JAY R SNODDY
• 金额: $ 16.06万
• 依托单位: VANDERBILT UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-07-01 至 2012-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7677526
• 关键词: Academic Medical Centers; Affect; Area; Assimilations; Biochemical; Bioinformatics; Biomedical Research; Biometry; Biostatistical Methods; Biostatistics Core; Client; Clinic; Collaborations; Communication; Communities; Data; Data Analyses; Data Files; Data Set; Depth; Development; Education; Ensure; Experimental Designs; Faculty; Fostering; Genes; Imagery; Informatics; Internet; Metadata; Molecular Genetics; Neurons; Neurosciences Research; Online Systems; Pathway Analysis; Production; Publications; Research; Research Design; Research Personnel; Resource Sharing; Resources; Serotonin; Signal Transduction; Site; System; Training; Work; analytical tool; data integration; data structure; design; open source; outreach; research and development; research study; tool; web-accessible

The Vanderbilt Conte Center for Neuroscience Research Signaling Networks Supporting Serotonin Transport engages multiple investigators and core resources to examine and define genetic, molecular, biochemical and cellular networks supporting of 5HT neuronal identity, development, signaling and plasticity. Advances from these basic studies ultimately to more translational arenas of biomedical research. Advances in bioinformatics and biostatistics created by the Bioinformatics/Biostatistics Core should also have impact in other areas of biomedical research and development. The Bioinformatics and Biostatistics Core will merge the efforts of several faculty and staff of the Biostatistics Department and the Biomedical Informatics Department at Vanderbilt University Medical Center in support of the Conte center. A key function will be statistical design of experiments and bioinformatics design of data structure and metadata to help ensure that the most meaningful experimental data is efficiently collected and analyzed. The core will use Biostatistics and Bioinformatics clinics and follow on work from these clinics. These clinics will allow experimentalists to produce for broader discussion "cases" of research problems and experiments. These clinics will also allow biostatistics and bioinformatics experts to arrange short tutorials in relevant topics for these cases and in the use of tools. Thus, these clinics should foster deep and ongoing interdisciplinary interactions before the experiments are done, after the experiments produce data, and after initial data analysis. Guided and dedicated support will be offered in the statistical and bioinformatics analysis of data sets from this center using the tools or approaches we develop and the tools or approaches of others. We will develop a web portal, SerotoninWorld.net that will perform several key functions. It will foster internal collaboration and sharing of preliminary data and analysis among researchers. It will foster sharing of completed resources to the entire research 5HT and neuroscience research community. This web portal will also provide an opportunity for education and broader outreach. This portal will assist in the greater ¿:suepmpaonrticmoertghaondiszationenoafbdleatainteoresutepdporbtiocmomedpiucatelr-raeseisatrecdhearscceinss5HtoTthresereasrecahrctoh rgestouarcceess.s Wtoenwewill publications and resources. Several tools and approaches to the analysis of data will be created, including the further development of WebGestalt and a client version that should directly affect the 5HT research community. Web-accessible data analysis tools developed in this project will be available to the entire research community. We will develop and exploit several open source projects and host them on sourceforge.net for broader community use and development.

范德比尔特孔戴神经科学研究信号网络支持5-羟色胺 运输参与多个研究人员和核心资源，以检查和定义遗传，分子， 支持5HT神经元身份，发育，信号和可塑性的生化和细胞网络。 这些基础研究的进步最终到了更翻译的生物医学研究领域。 生物信息学/生物统计学核心创造的生物信息学和生物统计学的进步也应 在生物医学研发的其他领域产生影响。生物信息学和生物统计学 核心将合并生物统计局和生物医学的几个教职员工的努力 范德比尔特大学医学中心的信息系支持孔戴中心。钥匙 功能将是实验的统计设计和数据结构和元数据的生物信息学设计 有助于确保有效地收集和分析最有意义的实验数据。核心意愿 使用生物统计学和生物信息学诊所，并遵循这些诊所的工作。这些诊所将允许 实验者生产研究问题和实验的更广泛讨论的“案例”。这些 诊所还将允许生物统计学和生物信息学专家安排有关相关主题的简短教程 这些情况和使用工具。那就是这些诊所应该促进深层而持续的跨学科 实验之前，实验产生数据之后和初始数据之后的相互作用 分析。数据将在数据的统计和生物信息学分析中提供指导和专用的支持 使用我们开发的工具或方法以及他人的工具或方法来设置该中心。我们 将开发一个Web门户，Serotoninworld.net，该网站将执行多个关键功能。它将促进内部 研究人员的初步数据和分析的协作和共享。它将促进共享 为整个研究完成了资源5HT和神经科学研究社区。这个网站将 还为教育和更广泛的外展提供了机会。此门户将有助于更大的 ¿ 出版物和资源。将创建几种数据分析的工具和方法，包括 Webgestalt和客户版本的进一步开发应直接影响5HT研究 社区。本项目中开发的Web可访问数据分析工具将用于整个 研究社区。我们将开发和利用几个开源项目，并托管它们 SourceForge.net，用于更广泛的社区使用和开发。