COGNITIVE FUNCTION IN SYSTEMIC LUPUS ERYTHEMATOSUS

系统性红斑狼疮的认知功能

• 批准号: 7604703
• 负责人: MICHELLE A PETRI
• 金额: $ 0.03万
• 依托单位: JOHNS HOPKINS UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-12-01 至 2007-09-16
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7604703
• 关键词: African American; Age; Alcohol abuse; American; Antibodies; Biological Markers; Brain; Classification; Clinic; Clinical; Cognitive; Computer Retrieval of Information on Scientific Projects Database; Connective Tissue Diseases; Craniocerebral Trauma; Diagnosis; Disease; Education; Enrollment; Ethnic Origin; Evaluation; Exclusion Criteria; Follow-Up Studies; Friends; Funding; Gender; Grant; Hispanics; Illicit Drugs; Impaired cognition; Informed Consent; Institution; Laboratories; Lesion; Lupus; Matched Group; Measures; Metric; Neurologic; Neuropsychiatric Systemic Lupus Erythematosus; Participant; Patients; Protocols documentation; Questionnaires; Recording of previous events; Recruitment Activity; Research; Research Personnel; Resources; Rheumatology; Risk Factors; Screening procedure; Source; Systemic Lupus Erythematosus; Testing; Time; Unconscious State; United States National Institutes of Health; Woman; Work; cognitive function; college; design; experience; men; neuropsychological

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. This protocol is designed to study cognitive function over time in subjects with Systemic Lupus Erythematosus (SLE) versus a matched group of normal healthy controls. Our prior work demonstrates that the persistent presence of antiphospholipid (aPL) and anti-ribosomal P (anti-P) antibodies is associated with cognitive dysfunction in SLE. Also, Hispanic (HA) ethnicity appears to be a separate risk factor for cognitive dysfunction. This finding is consistent with the more severe disease course overall that has been observed in African American (AA) and HA SLE patients in other studies. The specific hypothesis which will be tested in this project are: 1. Determine the magnitude of change over time in the quantitative measures of cognitive function using ANAM (Automated Neuropsychological Assessment Metrics) and the ACR (American College of Rheumatology) battery among SLE patients compared with healthy controls. 2. Determine whether cognitive impairment in SLE patients is associated with persistently positive biomarker levels. RESEARCH PLAN: We will recruit SLE patients from the Lupus Clinic for enrollment in the study. SLE subjects meeting 4 or more ACR revised criteria for the classification of SLE will be eligible. Both women and men will be enrolled. Subjects will not be excluded because they currently have or have a history of NPSLE (Neuropsychiatric systemic lupus erythematosus) manifestations. Exclusion criteria include: prior experience taking ANAM, history of head trauma leading to loss of consciousness, current illicit drug or alcohol abuse, known structural brain lesion, inability to complete study follow-up, inability to give informed consent. Participants will be asked to identify a friend who is willing to participate in the study as a control subject. One healthy control subject will be matched to each SLE subject by age (¿5 years), education, gender, and ethnicity. In addition, controls will be excluded if they have clinical or laboratory abnormalities that could be consistent with the diagnosis of SLE. This will be determined by administering the Connective Tissue Disease Screening Questionnaire. METHODS: Serial neurological, cognitive, psychiatric, rheumatological, and immunological evaluations will be performed every 6 months.

该副本是使用众多研究子项目之一 由NIH/NCRR资助的中心赠款提供的资源。子弹和 调查员（PI）可能已经从其他NIH来源获得了主要资金， 因此可以在其他清晰的条目中代表。列出的机构是 对于中心，这是调查员的机构。 该方案旨在研究全身性红斑狼疮（SLE）与一组正常健康对照组的受试者的认知功能。我们先前的工作表明，抗磷脂（APL）和抗核糖体P（抗P）抗体的持续存在与SLE中的认知功能障碍有关。同样，西班牙裔（HA）种族似乎是认知功能障碍的单独危险因素。这一发现与在其他研究中在非裔美国人（AA）和HA SLE患者中观察到的总体疾病病程一致。将在该项目中测试的具体假设是：1。使用ANAM（自动化的神经心理评估指标）和ACR（美国风湿病学院）在SLE患者中，确定认知功能的变化大小随时间的变化幅度。 2。确定SLE患者的认​​知障碍是否与持续的阳性生物标志物水平有关。 研究计划：我们将招募狼疮诊所的SLE患者进行研究。 SLE受试者符合4个或更多的ACR修订标准，以符合SLE的分类。男女都将入学。受试者不会被排除在外，因为他们目前有或拥有NPSLE（神经精神症状狼疮的红斑狼疮）表现。排除标准包括：先前接受ANAM的经验，导致意识丧失的头部创伤病史，当前的非法药物或酗酒，已知的结构性脑病变，无法完成研究随访，无法给予知情同意。 将要求参与者确定愿意参加研究作为对照主题的朋友。一个健康的控制主题将按年龄（5岁），教育，性别和种族匹配每个SLE主题。此外，如果对照组的临床或实验室异常可能与SLE诊断一致，则将排除对照组。这将通过管理结缔组织疾病筛查问卷来确定。 方法：将每6个月进行连续神经，认知，精神病学，流变学和免疫学评估。