DOPAMINE-RLS CONNECTION

多巴胺-RLS 连接

• 批准号: 7604739
• 负责人: CHRISTOPHER J EARLEY
• 金额: $ 0.02万
• 依托单位: JOHNS HOPKINS UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-12-01 至 2007-09-16
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7604739
• 关键词: Age; Arts; Autopsy; Brain; Clinical; Computer Retrieval of Information on Scientific Projects Database; Corpus striatum structure; Data; Dopamine; Dopamine Antagonists; Funding; Grant; Imaging Techniques; Institution; Iron; Magnetic Resonance Imaging; Measures; Midbrain structure; Patients; Phase; Play; Positron-Emission Tomography; Production; Research; Research Personnel; Resources; Restless Legs Syndrome; Role; Sensory; Severities; Source; Symptoms; System; United States National Institutes of Health; Ventral Striatum; day; design; dopamine system; ferryl iron; motor disorder; receptor binding; response

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Restless Legs Syndrome (RLS) is a sensory-motor disorder in which the dopaminergic system and brain iron appear to play a role. The dramatic symptomatic response to L-DOPA in over 98% of RLS subjects and the induction of RLS-like symptoms with dopamine (DA) antagonists provide convincing evidence for the role of the dopaminergic system in the production of RLS symptoms per se. The autopsy, CSF, MRI, and IV iron treatment data indicate a role of BRAIN iron deficiency in RLS. This study is designed to explore for abnormalities in the nigrostriatal (PET imaging of midbrain and striatum) and mesolimbic (PET imaging of ventral striatum/n. accumbens) Dopaminergic systems during the day. The DA-2 receptor (D2R) binding potential and Bmax, and DAT will be measured with state-of-the-art PET imaging techniques from 8:30-12 am. Any changes that are found in the DA system will be correlated with MRI measures of regional brain iron concentrations and measures of clinical severity. Idiopathic RLS patients and aged-matched controls will be studied in this Phase.

该副本是利用众多研究子项目之一 由NIH/NCRR资助的中心赠款提供的资源。子弹和 调查员（PI）可能已经从其他NIH来源获得了主要资金， 因此可以在其他清晰的条目中代表。列出的机构是 对于中心，这不一定是调查员的机构。 不安的腿综合征（RLS）是一种感觉运动障碍，其中多巴胺能系统和脑铁似乎起作用。 超过98％的RLS受试者对L-DOPA的显着症状反应以及多巴胺（DA）拮抗剂诱导RLS样症状，为多巴胺能体系在产生RLS症状的作用的作用提供了令人信服的证据。 尸检，CSF，MRI和IV铁处理数据表明脑铁缺乏在RLS中的作用。 这项研究旨在探讨白天在黑质纹状体（中脑和纹状体的PET成像）和中唇（腹侧纹状体/N。Accumbens）多巴胺能系统的异常。 DA-2受体（D2R）结合势和BMAX以及DAT将使用最新的PET成像技术从8：30-12 AM开始测量。 DA系统中发现的任何变化都将与区域脑铁浓度和临床严重程度衡量的MRI度量相关。 特发性RLS患者和年龄匹配的对照将在此阶段进行研究。