SYSTEMIC IRON METABOLISM IN RESTLESS LEGS SYNDROME

不宁腿综合征的全身铁代谢

• 批准号: 7607473
• 负责人: CHRISTOPHER J EARLEY
• 金额: $ 0.34万
• 依托单位: JOHNS HOPKINS UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-12-01 至 2007-09-16
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7607473
• 关键词: Computer Retrieval of Information on Scientific Projects Database; Excretory function; Ferritin; Funding; Grant; Institution; Iron; Kidney; Oral; Patients; Plasma; Relative (related person); Research; Research Personnel; Resources; Restless Legs Syndrome; Source; United States National Institutes of Health; absorption; iron metabolism

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. These investigators have demonstrated that iron metabolism differs in subjects with Restless Leg syndrome (RLS). They seek now to further characterize the mechanism of the relative iron deficiency observed in RLS. Patients with RLS may have reduced iron either from reduced absorption, increased turnover or increased excretion. These investigators hypothesize that RLS patients have lower absorption of oral iron than normal subjects when controlling for ferritin levels. Furthermore, they hypothesize that the apparent loss of iron observed in RLS patients is due to increased renal excretion of iron. In addition, the investigators hypothesize that RLS subjects will demonstrate a more rapid elimination or turnover of iron from the plasma pool than seen in normal subjects.

该副本是利用众多研究子项目之一 由NIH/NCRR资助的中心赠款提供的资源。子弹和 调查员（PI）可能已经从其他NIH来源获得了主要资金， 因此可以在其他清晰的条目中代表。列出的机构是 对于中心，这不一定是调查员的机构。 这些研究者表明，铁代谢在不安腿综合征（RLS）的受试者中有所不同。他们现在寻求进一步表征RLS中观察到的相对铁缺乏的机制。 RLS患者的吸收减少，营业额增加或排泄增加可能会减少铁。 这些研究者假设在控制铁蛋白水平时，RLS患者的口服铁吸收低于正常受试者。此外，他们假设在RLS患者中观察到的铁的明显丧失是由于铁的肾脏排泄增加所致。此外，研究人员假设RLS受试者将表现出比正常受试者中的血浆池的快速消除或营业率。