ACTIVITY DEPENDENT REFINEMENT OF INHIBITORY NETWORKS IN BARREL CORTEX

桶状皮层抑制网络的活动依赖性细化

• 批准号: 7720472
• 负责人: Qian-Quan Sun
• 金额: $ 18.22万
• 依托单位: UNIVERSITY OF WYOMING
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-07-01 至 2009-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7720472
• 关键词: Brain; Cerebral cortex; Chromosome Pairing; Computer Retrieval of Information on Scientific Projects Database; Condition; Cortical Dysplasia; Development; Dyslexia; Epilepsy; Equilibrium; Funding; Glutamates; Grant; Inhibitory Synapse; Institution; Interneurons; Microscopic; Modification; Neurons; Process; Property; Research; Research Personnel; Resources; Role; Schizophrenia; Sensory; Source; Synapses; System; Translating; United States National Institutes of Health; barrel cortex; experience; insight; neocortical; nervous system disorder; postnatal

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The aim of this proposal is to understand the mechanisms by which developing inhibitory brain circuits are able to adapt to sensory inputs, and to maintain their balance with the developing excitatory circuits. During early brain development, neurons in the cerebral cortex establish connections that are then fine tuned by experience-dependent mechanisms. Although much is now known regarding processes of glutamatergic maturation and activity-dependent modification of glutamatergic synapses for network formation, postnatal development of neocortical GABAergic synapses and their role in activity-dependent modification remains unclear. The proposed research will utilize a combination of electrophysiologic recording and microscopic analyses to examine how developmental changes of inhibitory synapses and interneuron network properties are translated into a mature, functional cortical system. This research will provide new information about mechanisms of cortical development and experience-dependant plasticity. It will help us gain further insights into mechanisms underlying several developmental related neurological disorders such as cortical dysplasia, schizophrenia, epilepsy and dyslexia, in which early endogenous and exogenous unfavorable conditions create long-lasting impacts on the mature cortex.

该副本是利用众多研究子项目之一 由NIH/NCRR资助的中心赠款提供的资源。子弹和 调查员（PI）可能已经从其他NIH来源获得了主要资金， 因此可以在其他清晰的条目中代表。列出的机构是 对于中心，这不一定是调查员的机构。 该提案的目的是了解发展抑制性脑电路能够适应感觉输入的机制，并与发展中的兴奋回路保持平衡。在早期大脑发育过程中，大脑皮层中的神经元建立了连接，然后通过经验依赖性机制进行了微调。尽管现在已经知道了谷氨酸能成熟的过程以及谷氨酸能突触的活动依赖性改性，以进行网络形成，但新皮层GABAergic突触的产后发展及其在活动依赖性修饰中的作用尚不清楚。拟议的研究将利用电生理记录和微观分析的组合来检查抑制突触的发育变化如何转化为成熟的功能性皮质系统。这项研究将提供有关皮质发育机制和经验依赖性可塑性的新信息。 它将有助于我们进一步了解几种相关神经系统疾病的基础机制，例如皮质发育异常，精神分裂症，癫痫和癫痫病，其中早期内源性和外源性不利的疾病会对成熟的皮质产生长期的影响。