Wyoming Sensory Biology COBRE

怀俄明州感官生物学 COBRE

• 批准号: 10714606
• 负责人: Qian-Quan Sun
• 金额: $ 35.65万
• 依托单位: UNIVERSITY OF WYOMING
• 依托单位国家: 美国
• 财政年份: 2017
• 资助国家: 美国
• 起止时间: 2017-09-01 至 2027-07-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10714606
• 关键词: Achievement; Adaptive Behaviors; Address; Affect; Aging; Alzheimer' s Disease; Alzheimer' s disease related dementia; Amyotrophic Lateral Sclerosis; Animal Model; Area; Awareness; Basic Science; Behavior; Biology; Biomedical Research; Cell Nucleus; Centers of Research Excellence; Child; Chronic Disease; Cognitive; Collaborations; Communication; Development; Disease; Educational Activities; Evaluation; Face; Fostering; Functional disorder; Funding; Goals; Growth; Health; Human; Impairment; Inflammation; Institution; Journals; Knowledge; Lateral; Long-Term Care; Manuscripts; Medial; Mental Health; Mental disorders; Mentors; Mission; Molecular; National Institute on Deafness and Other Communication Disorders; Neuroglia; Neurons; Obesity; Output; Oxytocin; Peer Review; Persons; Phase; Physiological; Positioning Attribute; Prefrontal Cortex; Process; Public Health; Publications; Publishing; Recovery; Research; Research Infrastructure; Research Personnel; Research Support; Resource Sharing; Resources; Role; Scientist; Sensory; Sensory Disorders; Sensory Process; Signal Transduction; Social Behavior; Spinal cord injury; System; Training; Translational Research; United States; United States National Institutes of Health; Universities; Wyoming; autism spectrum disorder; chronic pain; cost; developmental disease; evidence base; human old age (65+); improved; innovation; interest; maladaptive behavior; multidisciplinary; nervous system disorder; next generation; novel; operation; parabrachial nucleus; parvocellular; programs; recruit; responsible research conduct; sensory mechanism; sensory stimulus; sensory system; social; visual learning

Abstract The primary mission of the Sensory Biology COBRE (SBC) is to foster and conduct high-quality scientific research that advances our understanding of human sensory systems and disorders related to them. A major role of the Center is to support and mentor the development of junior investigators to pursue research in sensory system function and dysfunction. During Phase I, the SBC spearheaded transformative changes in the landscape of Sensory Biology Research. In addition to basic research related to the fundamental mechanisms of sensory processing and the role of the sensory system in social and cognitive behaviors, SBC labs also focused on translational research in mental health and psychiatric disorders. For the Phase II period, the SBC will continue to tackle the most critical public health issues relevant to the State of Wyoming for the 21st century, including aging and chronic diseases and conditions such as Alzheimer’s disease and related dementias (AD/RD), amyotrophic lateral sclerosis (ALS), developmental disorders that affect communication and behavior in children (autism spectrum disorders, ASD), and recovery from spinal cord injury (SCI). The Phase II Center will support four initial project leaders who will study the key roles of novel circuits in neurological disorders: the role of the lateral parabrachial nucleus in sundowning associated with AD/RD; the role of the medial prefrontal cortex in ALS and AD/RD; the role of oxytocin neurons in the parvocellular nucleus in pro-social behavior and disruptions of social behavior in ASD; and the role of electrical signaling that drives inflammation and glia bridging in the recovery from SCI. SBC will enhance the research quality and output of the junior investigators by providing mentoring, collaboration, and training and by sharing resources and animal models. The successful execution of SBC’s Phase II goal will help propel the SBC into Phase III where SBC will become an independent, thriving, and sustainable Center of Excellence, comprised of over fifteen independently funded labs and a multi-disciplinary biomedical research program. To achieve this goal, we propose the following four specific aims for the Phase II period: Aim 1. Expand the research scope to tackle important health issues relevant to the State of Wyoming. Aim 2. Advance the Phase II center by providing more effective administrative oversight of the research, finance, mentoring, and evaluation activities. Aim 3. Enhance the operational efficiency and the long-term self-sustainability of the Core. Aim 4. Bolster the growth achieved during Phase I by leveraging Phase II financial resources to recruit new junior investigators and increase their integration into thematic programs. Support of Phase II is crucial to our efforts in building a sustainable research center in the State of Wyoming. The support of Phase II will garner the institutional support needed for the long-term self-sustainability of the Center post-IDeA funding.

抽象的 感觉生物学毛病（SBC）的主要任务是培养和进行高质量的科学 研究我们对与它们相关的人类感觉系统和疾病的理解的发展。专业 该中心的作用是支持和指导初级研究人员的发展，以从事研究 感觉系统功能和功能障碍。在第一阶段，SBC矛盾的变化变化 感觉生物学研究的景观。除了基本研究与基本机制有关的基础研究 感官处理以及感觉系统在社会和认知行为中的作用，SBC实验室也 专注于精神健康和精神疾病的翻译研究。在II期时期，SBC 将继续解决与怀俄明州第21届怀俄明州有关的最关键的公共卫生问题 世纪，包括衰老和慢性疾病以及阿尔茨海默氏病及相关状况 痴呆症（AD/RD），肌萎缩性侧面硬化症（ALS），影响交流的发育障碍 儿童（自闭症谱系障碍，ASD）和脊髓损伤（SCI）的行为。 第二阶段中心将支持四个初始项目负责人，他们将研究新电路的关键作用 神经系统疾病：侧旁核核在与AD/RD相关的日落中的作用；这 内侧前额叶皮层在ALS和AD/RD中的作用；氧气神经元在副细胞核中的作用 在ASD的亲社会行为和社会行为的破坏中；以及驱动的电信号的作用 炎症和神经胶质在从SCI中恢复中桥接。 SBC将提高研究质量和产出 初级调查人员通过提供心理，协作和培训，并通过共享资源和动物 型号。 SBC II阶段目标的成功执行将有助于推动SBC进入SBC的第三阶段 将成为一个独立，繁荣和可持续的卓越中心，由十五多个 独立资助的实验室和多学科生物医学研究计划。为了实现这一目标，我们 提案以下四个针对第二阶段时期的特定目标：目标1。扩大研究范围以解决 与怀俄明州有关的重要健康问题。目标2。通过提供II期中心 对研究，金融，心理和评估活动的更有效的行政监督。目标3。 提高核心的操作效率和长期自我可持续性。目标4。加强增长 在第一阶段通过利用第二阶段财政资源来招募新的初级调查人员和 将其集成到主题计划中。对第二阶段的支持对于我们为建立一个努力至关重要 怀俄明州的可持续研究中心。第二阶段的支持将获得机构 中心后IDEA资金的长期自我可持续性所需的支持。