COBRE: NDS U: ADMIN: NEW STRATEGIES FOR TARGETING PROTEASES IN DISEASE

COBRE：NDS U：管理员：针对疾病中的蛋白酶的新策略

• 批准号: 7720850
• 负责人: MUKUND P. SIBI
• 金额: $ 206.35万
• 依托单位: NORTH DAKOTA STATE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-07-01 至 2009-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7720850
• 关键词: Address; Biomedical Research; Budgets; Centers of Research Excellence; Computer Retrieval of Information on Scientific Projects Database; Core Facility; Development; Disease; Educational workshop; Endopeptidases; Enzyme Inhibitor Drugs; Enzyme Inhibitors; Faculty; Family; Fellowship; Fellowship Program; Funding; Goals; Grant; Health; Homeostasis; Human Resources; Institution; Matrix Metalloproteinases; North Dakota; Numbers; Peptide Hydrolases; Plasmin; Play; Postdoctoral Fellow; Qualifying; Research; Research Activity; Research Personnel; Resources; Role; Seeds; Serine Protease; Source; Students; Therapeutic; United States National Institutes of Health; Urokinase; Zinc; college; design; in vivo; inhibitor/antagonist; interest; metalloenzyme; programs

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The program will consist of three projects and a central core facility with each addressing a critical aspect of the overall goal. The focus of the Center will be the development of therapeutic inhibitors for matrix proteinases, which include the family of zinc-dependent matrix metalloenzymes (MMP's), and the serine proteases (SP's), urokinase plasminogen activator (uPA) and plasmin. The majority of effort of this project is the inhibition of MMP's. But, the two serine proteases also play critical roles in matrix homeostasis in both health and disease. A part of the effort will be directed towards the design and optimization of inhibitors for these enzymes. This effort will consist of four interrelated projects. North Dakota, like other EPSCoR states, does not submit enough proposals to NIH. To address this problem, the COBRE Center will dedicate a large part of its budget to Human Resources. This center will increase the number of faculty with biomedical research interests by providing startup funds for a new in vivo biologist. Research activities in the Center will bring to North Dakota qualified technicians, postdoctoral associates, and students. Additionally, the center will initiate several programs to increase biomedical research in the state. These initiatives include : seed grants for North Dakota faculty, establishment of a graduate fellowship program, post-doctoral fellowships summer research program for undergraduates and faculty from 4-year colleges, and NIH workshops.

该副本是利用众多研究子项目之一 由NIH/NCRR资助的中心赠款提供的资源。子弹和 调查员（PI）可能已经从其他NIH来源获得了主要资金， 因此可以在其他清晰的条目中代表。列出的机构是 对于中心，这不一定是调查员的机构。 该计划将包括三个项目和一个中央核心设施，每个项目都解决了整体目标的关键方面。该中心的重点将是基质蛋白酶的治疗性抑制剂的开发，其中包括锌依赖性基质基质金属酶（MMP）以及丝氨酸蛋白酶（SP），尿蛋白酶纤溶酶蛋白原激活剂（UPA）和纤溶酶。该项目的大部分努力是抑制MMP。但是，这两种丝氨酸蛋白酶在健康和疾病中都在基质稳态中起关键作用。一部分努力将针对这些酶的抑制剂设计和优化。这项工作将由四个相互关联的项目组成。与其他EPSCOR州一样，北达科他州没有向NIH提出足够的建议。为了解决这个问题，毛绒中心将大部分预算专用于人力资源。该中心将通过为新的体内生物学家提供启动资金来增加具有生物医学研究利益的教师数量。该中心的研究活动将带给北达科他州合格的技术人员，博士后员工和学生。此外，该中心将启动几个计划，以增加该州的生物医学研究。这些举措包括：北达科他州教职员工的种子赠款，建立研究生奖学金计划，4年大学的本科生和教职员工的博士后研究金奖学金和NIH研讨会。