CORE BIOLOGY AND SYNTHESIS FACILITIES

核心生物学和合成设施

• 批准号: 8167861
• 负责人: MUKUND P. SIBI
• 金额: $ 53.47万
• 依托单位: NORTH DAKOTA STATE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-07-01 至 2011-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8167861
• 关键词: Arts; Biological Assay; Biology; Centers of Research Excellence; Computer Retrieval of Information on Scientific Projects Database; Consultations; Core Facility; Equipment; Experimental Designs; Faculty; Funding; Goals; Grant; Histone Deacetylase Inhibitor; Human Resources; Human Resources Development; Institution; Lead; Matrix Metalloproteinases; Molecular Biology; North Dakota; Play; Qualifying; Reagent; Research; Research Personnel; Resources; Role; Source; Structure-Activity Relationship; Training; United States National Institutes of Health; analog; design; drug discovery; efficacy testing; in vitro Bioassay; success; tissue culture; tool

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The Center views the activities of the core facilities to be central to the success of its scientific and human resource development goals. The main objectives are to maintain the activity of the Core Biology Facility and establish a state-of-the-art Core Synthetic Facility that will impact research at NDSU and beyond. These facilities will provide training for researchers, consultation in experimental design, and function as a resource for equipment. The qualified personnel in these core facilities will assist junior investigators and will also play a key role in assisting other NDSU researchers and faculty in the state of North Dakota. The Core Biology Facility was established in 2003. It is comprised of three components: Tissue Culture, Molecular Biology, and Bioassays, and offers training and use of equipment and reagents to researchers. Additionally, the lab is staffed with personnel to perform routine bioassays and in vitro biological assays. The facility routinely performs the essential testing for the efficacy of the MMP and HDAC inhibitors designed by the original COBRE investigators. The establishment of a Synthetic core is intended to aid all biomedical researchers by providing small organic molecules for research tools and to increase the throughput of current drug discovery endeavors in the Center. A facility that can provide rapid and parallel synthesis of many analogs of a lead compound is crucial for understanding structure activity relationships and developing new directions.

该副本是利用众多研究子项目之一 由NIH/NCRR资助的中心赠款提供的资源。子弹和 调查员（PI）可能已经从其他NIH来源获得了主要资金， 因此可以在其他清晰的条目中代表。列出的机构是 对于中心，这不一定是调查员的机构。 该中心认为核心设施的活动是其科学成功的核心 和人力资源发展目标。主要目的是维护 核心生物学设施并建立最先进的核心合成设施，将影响 NDSU及其他地区的研究。这些设施将为研究人员提供培训，咨询 在实验设计中，作为设备资源的功能。合格人员 这些核心设施将协助初级调查人员，并且在协助其他人方面也将发挥关键作用 北达科他州的NDSU研究人员和教职员工。 核心生物学设施于2003年成立。它由三个组成部分组成：组织 培养，分子生物学和生物测定，并提供设备的培训和使用， 研究人员的试剂。此外，实验室配备人员以执行例行 生物测定和体外生物学测定。该设施通常对 MMP和HDAC抑制剂的功效是由原始的鞋垫研究人员设计的。 合成核心的建立旨在通过为研究工具提供小的有机分子来帮助所有生物医学研究人员，并增加当前药物发现努力的吞吐量。可以提供铅化合物许多类似物的快速和平行合成的设施对于理解结构活动关系和开发新方向至关重要。