Center for Protease Research

蛋白酶研究中心

基本信息

批准号：
9102220
负责人：
MUKUND P. SIBI
金额：
$ 104.05万
依托单位：
NORTH DAKOTA STATE UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2012
资助国家：
美国
起止时间：
2012-09-24 至 2019-06-30
项目状态：
已结题

项目摘要

DESCRIPTION (provided by applicant): This is a proposal requesting Phase III support for five years to continue our successful COBRE Center for Protease Research (CPR) at North Dakota State University (NDSU), which was established in 2001 with Phase I of grant P20RR15566. The overarching goal for the Center is to obtain fundamental understanding of the role of proteases in disease in the broadest sense. During the first ten years, the Center has funded twenty-seven faculty researchers and established two core facilities. Several of these faculty members have received major research funding awards from NIH and NSF (R01, CAREER, and Presidential Young Investigator Awards) and the majority of the junior faculty have successfully competed for NIH (R03, R15, and R21), American Heart Association, or Department of Defense grants. In total, the Center PIs have received more than $17,500,000 in new funding and an additional $1,000,000 in education grants. The PIs from the Center have published 335 peer-reviewed publications since 2001. The strategic plan for Phase III of the CPR COBRE Center during the next five years is (1) to maintain and strengthen the state-of-the-art Core Biology and Core Synthesis Facilities established during Phases I and II that are essential for the support of the research projects in the Center, (2) to support research pilot projects and training components to sustain a collaborative, multidisciplinary research environment, (3) to provide significant mentoring in professional activities for the development of junior faculty members, and (4) to maintain an administrative core that will be required to coordinate and evaluate the entire program, including the Pilot Project Program and the two research cores. In this application, the Center for Protease Research is requesting funds to continue its support of two core facilities, to establish a new Pilot Project Program for biomedical research, and an Administrative Core to coordinate these activities. NDSU has clearly recognized the tremendous resources the Center brings to bear on its continued development as a research-intensive university. Over the course of the requested Phase III grant, NDSU will contribute $1,250,000 in direct support of the Center.

描述（由申请人提供）：这是一项提案，要求在北达科他州立大学（NDSU）成功的五年支持五年的III阶段支持，该提案于2001年建立，该中心于2001年建立，并于2001年建立了授予P20RR15566的I期。该中心的总体目标是在最广泛的意义上获得对蛋白酶在疾病中的作用的基本理解。在最初的十年中，该中心资助了27名教师研究人员，并建立了两个核心设施。这些教职员工中有几名获得了NIH和NSF（R01，职业和总统年轻调查员奖）的重大研究资金奖，而大多数初级教师成功地争夺了NIH（R03，R15和R21），美国心脏病协会或国防部的国防部。总共，PIS中心已获得超过17,500,000美元的新资金和100万美元的教育补助金。自2001年以来，该中心的PI已发表了335份同行评审的出版物。接下来的五年中，CPR Cobre中心第三阶段的战略计划是（1）是（1）是（1）维护和加强先进的核心生物学和核心合成设施，在第一阶段和II期间建立的核心合成设施是为了支持研究项目的必不可少的研究，以支持该中心的研究，以支持该中心（2）（2）（2）（2）（2）（2）（2），（2）培训（2）（2）（2），2）多学科研究环境，（3）为开发专业活动提供重要的指导初级教师和（4）要维护一个行政核心，该核心将被要求协调和评估整个计划，包括试点项目计划和两个研究核心。在本应用程序中，蛋白酶研究中心要求资金继续支持两个核心设施，以建立一个新的生物医学研究试点项目计划，并是协调这些活动的行政核心。 NDSU清楚地意识到了该中心带来的巨大资源，以继续发展其作为一所研究密集型大学的持续发展。在要求的第三阶段赠款的过程中，NDSU将为中心提供1,250,000美元的贡献。