CLINICAL TRIAL: DOSE - AHF

临床试验：剂量 - AHF

• 批准号: 7720630
• 负责人: Elizabeth O. Ofili
• 金额: $ 5.86万
• 依托单位: MOREHOUSE SCHOOL OF MEDICINE
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-08-01 至 2009-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7720630
• 关键词: Acute; Area Under Curve; Bolus Infusion; Clinical Trials; Computer Retrieval of Information on Scientific Projects Database; Creatinine; Daily; Dose; Functional disorder; Funding; Furosemide; Grant; Hour; Institution; Intravenous Bolus; Intravenous infusion procedures; Kidney; Measures; Personal Satisfaction; Randomized; Research; Research Personnel; Resources; Serum; Source; Symptoms; United States National Institutes of Health; Visual; analog

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The hypothesis of this trial is 1) That a low intensification strategy causes less renal dysfunction than a "high intensification strategy, as measured by change in serum creatinine from randomization to 72 hours. 2) That a "low intensification" strategy is equally efficacious in relieving acute symptoms compared to "high intensification" strategy, as measured by the area under the curve of serial visual analog assessments for global well being over 72 hours. 3) That continuous IV infusion of furosemide causes less renal dysfunction than twice daily IV bolus administration, as measured by change in creatinine from baseline to 72 hours. 4) That continuous IV infusion of furosemide is more efficacious at relieving acute symptoms compared to twice daily bolus administration, as measured by the area under the curve of serial visual analog assessments for global well being over 72 hours.

该副本是利用众多研究子项目之一 由NIH/NCRR资助的中心赠款提供的资源。子弹和 调查员（PI）可能已经从其他NIH来源获得了主要资金， 因此可以在其他清晰的条目中代表。列出的机构是 对于中心，这不一定是调查员的机构。 该试验的假设是1）低强度策略所引起的肾功能障碍比“高强化策略，这是通过从随机化到72小时的血清肌酐变化来衡量的。2）“低强化”策略在与“高强化策略”相比，在急性范围内相比，在急性较高的策略中相比，良好的区域相比，“低强化”策略同样有效地在急性症状上进行了良好的效果，从而及时进行了良好的效果，并及时地进行了良好的效果，并及时地进行了良好的疗法，从而使练习率及时良好，从而使该策略进行了良好的效果。 3）连续静脉输注速尿会导致肾功能障碍少于每天两次静脉输液，这是通过从基线到72小时的肌酐​​变化来衡量的。连续IV静脉输注的速食更有效地在急性症状上与抗扭曲的症状相比，与每天的抗衡症相比，该区域均在急性范围内进行了测量。